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Glukosa-6-fosfatase

Glukosa-6-fosfatase. Kelompok 2 Sasmaya 10508044 Letizia Prima 10509001 Bella Peridoti P 10509007 Luthfie Nur’azizah 10509009 Surya Dewi W 10509013 Anindita Ayu m aulani 10509019 Flavia Manuela 10509023. Pengertian.

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Glukosa-6-fosfatase

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  1. Glukosa-6-fosfatase Kelompok 2 Sasmaya 10508044 Letizia Prima 10509001 Bella PeridotiP 10509007 LuthfieNur’azizah10509009 Surya DewiW 10509013 AninditaAyumaulani 10509019 Flavia Manuela 10509023

  2. Pengertian • Glukosa-6-fosfatase (G6P) adalahenzimyang menghidrolisisglukosa6-fosfat menjadiglukosa, ataudefosforilasiglukosa. • Berperandalamtahapterakhirsiklusglukoneogenesis • Tempat : banyakterdapatdalamhatidankorteksginjal

  3. Struktur Glukosa-6-Fosfat

  4. FungsiGlukosa-6- fosfatase • Menghasilkankadarglukosadarah • Pemecahanglikogenhati. • Untukpemecahanglikogenmenjadiglukosaterdapatpadareaksiglikogenolisis.

  5. SiklusGlukoneogenesis

  6. Reaksiterkatalisisenzimglukosa6-fosfatase tidakmembutuhkansintesisATP. • Reaksinyamerupakanhidrolisissederhanadarifosfatester. Glukosa 6-fosfat + H2O  Glukosa+ Pi ΔG = -13,8 kJ/mol

  7. Kofaktor : Mg2+ dan Ca2+ • pH optimum = 7,8 Glukosa6-fosfat darihepatositselhati

  8. InformasiTambahan • Cacat gen terjadiapabilaenzimglukosa6-fosfat tidakdapatmengubahglikogenmenjadiglukosa. Gejala yang munculadalahpembengkakanhatidangagalginjal. • Glukosa-6-Fosfatase meningkatpadasaatberpuasadanproseskelahiran.

  9. Diagram skematik protein-protein RE yang berperansertadalampembentukanglukosadisitosol. Keterangan : T1 : mengangkutglukosa6-fosfat kedalamlumen RE (CS) T2 : mengangkut Pi kembalikesitosol T3 : mengangkutglukosakembalikesitosol SP : protein pengikat, Mg2+

  10. GLUT2 terdapatpadahatidanselβ-pankreas. Glukosa yang dihasilkankeluardarihatimelaluiGLUT2 melewatimembransel.

  11. TerimaKasih

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