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Amyloidosis

AMYLOIDOSIS . Amyloid is a pathologic proteinaceous substance, deposited between cells in various tissues and organs of the body in a wide variety of clinical settings.Amyloidosis is not a single disease; rather it is a group of diseases having in common the deposition of similar-appearing proteins

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Amyloidosis

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    1. Amyloidosis Dr Hisham Alkhalidi

    2. AMYLOIDOSIS Amyloid is a pathologic proteinaceous substance, deposited between cells in various tissues and organs of the body in a wide variety of clinical settings. Amyloidosis is not a single disease; rather it is a group of diseases having in common the deposition of similar-appearing proteins.

    3. AMYLOIDOSIS It is a condition associated with a number of inherited and inflammatory disorders in which extracellular deposits of fibrillar proteins are responsible for tissue damage and functional compromise. These abnormal fibrils are produced by the aggregation of misfolded proteins (which are soluble in their normal folded configuration).

    4. The fibrillar deposits bind a wide variety of: Proteoglycans Glycosaminoglycans Plasma proteins, notably serum amyloid P component (SAP) - Approximately 95% of the amyloid material consists of fibril proteins The remaining 5% is P component and other glycoproteins. Chemical Nature of Amyloid

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