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This study investigates the influence of GlnR on the expression of cold-specific DNA genes, msmeg_1885 and msmeg_1886, in Mycobacterium smegmatis. We explore the distinction between non-specific and specific cold responses, highlighting the regulatory mechanisms that govern gene expression under cold stress. By analyzing the input excess and limiting factors, we uncover how GlnR functions as a key regulator in the cold stress response, providing insight into the adaptation mechanisms of mycobacterial species in fluctuating temperatures.
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Non- specific cold DNA Specific cold DNA GlnR - input excess limiting gene expression msmeg_1885 msmeg_1886