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As A Biotherapeutic Agent In Clinical Nutrition

As A Biotherapeutic Agent In Clinical Nutrition. Microbial Cell Preparation Efficacy Established Scientifically Proven Safe For Consumption Palatable Flavour No Reported Side Effect Registered With National Pharmaceutical Control Bureau. IMPROVE QOL. CLINICAL NUTRITION.

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As A Biotherapeutic Agent In Clinical Nutrition

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  1. As A Biotherapeutic Agent In Clinical Nutrition

  2. Microbial Cell Preparation • Efficacy Established • Scientifically Proven Safe For Consumption • Palatable Flavour • No Reported Side Effect • Registered With National Pharmaceutical Control Bureau

  3. IMPROVE QOL CLINICAL NUTRITION ABSORPTION

  4. & Constipation

  5. Pathophysiology of Constipation

  6. Stress Medication Bed Ridden Patients Laxative Abuse Vulnerable Groups Pregnant Mothers Aged Population Premature Babies Travelling Individual

  7. Prolonged Constipation May Lead To: • Hemorrhoids • Anal fissure • Diarrhea • Fecal incontinence • Rectal bleeding • Rectal prolapse • Rectal hernia • Fecal impaction • Uterine hernia • Uterine prolapse www.wrongdiagnosis.com

  8. Prolong Constipation:Hemorrhoids

  9. Rectal Prolapse Rectal Bleeding Anal Fissure Uterine Prolapse

  10. Hexbio Improves Chronic Constipation

  11. Demographic and Clinical characteristics Number of patients according to gender The study of “Efficacy of in Improving Chronic Constipation” was conducted in 12 patients consisting of 5 males and 7 females. Figure shows the total of patients (N) involved in the study according to gender.

  12. Demographic and Clinical characteristics 2 31 years 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 22 83 Years of constipation Age of patients Age of patients and years of constipation Chart shows the age of the patients ranging from 22 to 83 years old and the years each patients suffer from constipation ranging from 2 to 31 years.

  13. Results Stool frequency p = 0.001 Stool frequency per week Above graph shows the frequency of stools during the study period of 7 days. According to the results, stool frequency increased from 1.4 time a week before treatment to 4.3 a week after treatment. This indicates the efficacy of in increasing patients’ bowel movement and reduces constipation.

  14. 4. 2 3.8 2.0 Role of Probiotic Mixture In Treatment Of Childhood Constipation Frequency of Bowel Movement The probiotic mixture was contained Bifidobacterium and lactobacillus. Frequency of Bowel Movement (BM) per week in 20 children we tested. According to the chart, the frequency of BMs in overall children increased in each week showing that the administration of probiotic mixture had a positive effect on frequency of BM. The role of probiotics mixture in the treatment of childhood constipation : a pilot study. Noor-L-Huada Bekkali, Marloes EJ Bongers, Maartje M Van den Berg, Olivia Liem and Marc A Benniga. Netherlands. Published in 4 August 2007.

  15. Prevalence of Irritable Bowel Syndrome on young adult. Malaysian: A survey among Medical Students A study to determine the prevalence of IBS and to assess the symptoms subgroups in young adult Malaysians was done. The results obtained had been categorized into few subgroups of symptoms as shown above. As conclusion, within the IBS population, the majority (77.4%) was of the constipation-predominant IBS subgroup. Prevalence of irritable bowel syndrome in young adult Malaysians: A survey among medical students. Tan, Yan-mei; Goh, Khean L; Muhidayah, Raja; Ooi, Chee L; Salem, Omar. Department of Medicine, Faculty of Medicine, University of Malaya.

  16. HOW HELPCONSTIPATION???

  17. Secretes organic acids, maintaining acidic environment that induce peristalsis. • Regularize bowel movement and shortens the Colonic Transit Time. Bekkali et. al. (2007). The role of probiotics mixture in the treatment of childhood constipation: a pilot study. Nutrition Journal 6: 17.

  18. & Diarrhea

  19. Is Like A Storm Raging Inside You & Its Shows Up At The Most Unexpected Time

  20. Diarrhea Frequent loose or liquid bowel movements, often due to disruption of water absorption in the colon

  21. Defense Mechanism • In the event of pathogenic infection, diarrhea functions as an evolved expulsion defense mechanism. • The appendix serves as a safe house for the good bacteria, protecting it from contamination and facilitating a re-start of the system once the contaminating organisms has been eliminated.

  22. Types of Diarrhea

  23. Treatment of Acute Gastroenteritis in Infants (6-12 months) From the study, 65 young children aged 6-12 months, suffering from acute gastroenteritis were treated daily until diarrhea resolution. As showed in the result, the feeding of microbial cell preparation reduced the severity and duration of acute gastroenteritis in young children. Raanan Shamir et. al, Evaluation of a diet containing probiotics for the treatment of mild diarrheal illness in children younger than one year of age, American College of Nutrition 2005; 24(Suppl. 5):370-375

  24. 61 children that tested positive for rotavirus were treated with microbial cell preparation/placebo for 6 days. Stools were collected and examined again after 6 days of treatment. In conclusion, oral administration of microbial cell preparation is effective in reducing the duration of rotavirus excretion. Guarino A et. al, Oral bacterial therapy reduces the duration of symptoms and of viral excretion in children with mild diarrhea, Department of Pediatrics, University Federico II of Naples, Italy

  25. The largest meta-analysis to evaluate 34 different clinical trials involving 4844 patients.  Result: Reduced the likelihood of developing antibiotic-associated diarrhea by 52%. Reduce Incidence of Antibiotic Associated Diarrhea • Conclusion: • The benefits were most pronounced among children.  Sazawal S, Hiremath G, Dhingra U, Malik P, Deb S, Black RE. Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomized, placebo-controlled trials. Lancet Infect Dis. 2006;6:374-382.

  26. An analysis to evaluate 34 different clinical trials involving 4844 patients.  Result: Reduced the incidence of acute diarrhea by 34%.  Review: In 12 pediatric studies included in this analysis, it reduced the likelihood of acute diarrhea in children by 57% (p<0.001) Reduce Incidence of Acute Diarrhea • Conclusion: • The benefits were most pronounced among children.  Sazawal S, Hiremath G, Dhingra U, Malik P, Deb S, Black RE. Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomized, placebo-controlled trials. Lancet Infect Dis. 2006;6:374-382.

  27. Combined Treatment (with ORS) of acute diarrhea in children 37 children aged 3 to 24 months received ORS as a form of rehydration, and were treated to microbial cell preparation at 12-hours interval until the resolution of diarrhea. In conclusion, addition of microbial cell preparation to ORS was effective in the treatment of children with acute diarrhea by decreasing the duration of diarrhea. Simakachorn N. et. al, Clinical evaluation of the addition of lyophilized Lactobacillus LB to oral rehydration therapy in the treatment of acute diarrhea in children, Journal of Pediatric Gastroenterology and Nutrition 0277-2116

  28. Hexbio® + ORS Gilliland et. al. (2001). Health and nutritional properties of probiotics in foods including powder milk with live Lactic Acid Bacteria, WHO/FAO

  29. HOW HELPDIARRHEA???

  30. Neutralize enterotoxins from pathogens. • Produce anti-microbial substances to suppress the growth of pathogens. • Reduce rotavirus shedding.

  31. & Immunity

  32. Cold and Flu • Common Cold – upper respiratory tract infection caused by either rhinoviruses or coronaviruses. • Flu – infectious disease caused by Influenza viruses.

  33. HOW HELPto induce immunity???

  34. Induces secretion of Immunoglobin A. • Increase level of T-Lymphocyte cells as well as other helper immune cells. • Activate the human myeloid dendrite cell (MDC) to induce immune response.

  35. Stimulation of T-Lymphocyte Level Consumption of microbial cell preparation able to stimulate the level of T-Lymphocyte cells. G. Perdigon et. al, Symposium: Probiotic bacteria for humans: Clinical systems for evaluation of effectiveness, Journal of Dairy Science 1995 78:1597-1606

  36. Reduction of Cold and Flu Symptoms • For 6 months, 326 children, aged 3 to 5 were treated twice a day. • Results: • Microbial cell preparation reduces the incidence and severity of cold and flu symptoms in children. Probiotic Effects on cold and influenza-like symptom incidence and duration in children. American Academy of Pediatrics

  37. & Other Diseases

  38. STROKE

  39. Chart shows the overall rates of complications in the Asian region. Among the non-neurologic complications, the most commonly encountered were chest infections, constipation and urinary retention with a rate of 19%, 15% and 11% respectively. Complication of Acute Stroke : A study in Ten Asian countries. Jose C.Navvaro MD MSc et.al, Neurology Asia 2008; 13:33-39. University of Santo Thomas, Espana, Manila, Phillipines.

  40. DIABETES

  41. DIABETES TYPE 1 Is a failure of the pancreas to produce insulin TYPE 2 Is insulin resistance or impaired glucose tolerance • Gastrointestinal Symptoms associated to Diabetic Complications. • Scientist state that 76% of DM patients undergo at least one gastrointestinal problem and the majority of them suffer from constipation. • The percentage are as shown below:-

  42. Diabetes Related GIT Symptoms Irritable Bowel Syndrome Constipation Dyschezia (Painful Defecation) Diarrhea Fecal incontinence Dyspepsia (Upset Stomach, Indigestion) Nausea /vomiting Heartburn

  43. The chart pie above shows the prevalence of GI tract symptoms among patients with DM type 1 compared to respective control. As showed above, the highest symptom stand of peripheral neuropathy for muscle numbness, continued by dyspepsia and constipation which holds the third place with percentage of 16.7%.

  44. The chart pie above shows the prevalence of GI tract symptoms among patients with DM type 2 compared to respective control. As showed above, the highest symptom is peripheral neuropathy with 51.6%, continued by heartburn 19.8%, dyspepsia 13.4% and constipation 10.1%.

  45. COLON CANCER

  46. Evaluation Of Stool DEFECATION.. Is not evaluated according to HOW MANY times we defecate.. It is evaluated according to the TYPES of stool that been eliminated.. Types of Stool

  47. Bristol Stool Chart Constipation Normal Diarrhea

  48. Bowel Movement (BM) Frequency and Risk of Colorectal Cancer in a Large Cohort Study of Japanese Men and Women IRR BM Above chart shows the average Incidence Rate Ratios (IRR) for colorectal and colon cancer according to BM frequency. As shown, it is the best to have BM every 2-3 days as it shows the lowest IRR. Too often of BM per day can cause higher risk of colon and colorectal cancer. This is the same with BM every 6 days or less which has IRR of 1.81 average for both men and women. British Journal of Cancer (2004) 90, 1397-1401

  49. Colon Cancer

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