PMBC

1. PMBC October 10, 2006 Drs. Matthews and Scheier

2. ? Disease (Body) Psychosocial Factors (Mind)

3. Psychological Pathways Chronic Burdens and Resource Bank: Biological • Demographics Pathways: • Social/environmental Disability • Personal attributes & Disease Psychosocial Interventions Precipitating Behavioral Events Pathways: • Health habits, • Restorative activities Life Span Development/Aging

4. Aims of PMBC • Unpack key concepts in model, decomposing them and subjecting them to a more micro-level analysis, e.g. Project on regional brain activation underlying CV responses to psychological stress • Test influence of the life course on the relationships in model • Cross-validate model with new disease

5. Aim #4. Establish Research Cores Consistent withour General Model to Support PMBC Research & Investigators • Psychosocial and health behavior assessment (psychological and health behavior pathways) • Sleep assessment and resources (health behavior pathway) • Biological and biomedical measurement (biological pathway) • Data management and statistical resources

6. Common Objectives of Research Support Cores • Provide expert consultation to PMBC community on most advanced techniques • Maintain on the PMBC website detailed information on descriptions of measures and standard measurement protocols and working papers • Provide advanced training • Propose research questions needed to be addressed to advance mind-body science

7. Aim #5. Develop Coordinated Faculty Development Program in Mind-Body Science (Faculty Development Infrastructure) • Advanced training in areas relevant to PMBC • Mind-Body Visiting Scholars Program • Release time for local junior clinical faculty

8. Aim #6. Continue annual summer institute on mind-body relationships and health

9. Concrete Products in PMBC-II • Identify some of the common pathways across diverse diseases • Understand key components in context of life course • Develop range of recommended, sometimes new, assessment tools • Provide the theoretical and empirical basis for efficacious interventions

10. Products Continued: • Promote innovative research thru pilot funds and faculty development program • Train next generation of leaders thru summer institutes • Serve as an international resource thru website • Obtain long-term institutional commitment to mind-body science and health at CMU and PITT beyond the funding period

12. Core A: Administration and Planning • Oversee the work of the following structures: • Center Executive Committee: composed of core leaders and developmental infrastructure leaders • Meetings of center faculty and key personnel • Internal and External Advisory Board meetings • Expanded PMBC website

13. Members of Internal Advisory Board • Ronald Herberman, Director, University of Pittsburgh Cancer Institute, PITT* • Mark Kamlet, Provost, CMU • Lewis Kuller, Director, Center for Successful Aging, PITT • David Kupfer, Chair, Department of Psychiatry, PITT* • John Lehoczky, Dean of the Humanities and Social Sciences College, CMU *Previous IAB member

14. Executive Committee Functions • Present targeted reviews of needed research • Plan innovative use of common funds to develop or use new methods • Decide how to use pilot funds • Ensure proposed activities of components meet overall goals of PMBC • Review progress of components

15. Core BData Management and Statistical Resources • Data Management Support • Statistical Consultation and Analytic Support • Training and Advanced Methods Workshops

16. Core C • Review and disseminate information about psychosocial and health behavior measures. • Website-based literature reviews • Psychosocial battery project • Training in novel or complex assessment methods. • Workshops on depression, life stress, EMA methods. • Upcoming workshop on health behavior assessment. • Research in assessment methods. • Life stress assessment, physical activity assessment, depression and metabolic function. • Consultation to colleagues about state-of-the-art methods. • Consultation on research by faculty scholars.

17. Core D • Theme: • To bridge research in two traditionally independent fields: sleep medicine and behavioral medicine. • Aims: • Provide education in mind-body sleep research. • Develop a tool box for mind-body sleep research. • Provide research support and model development in order to advance mind-body sleep research.

18. Core E • Biological Measurement • established a referral panel to provide advice to Center members • website descriptions of common biomarkers, references and standard measurement protocols • list local laboratories providing assays and instrumentation • training in areas of biological measurement relevant to Center members • funding for development of new measurement techniques, to establish measurement validity

19. 2005-2006 Center Activities – Many Sponsored by Faculty Development Infrastructure • Workshops - Assessment of Depression in Mind-Body Research, EMA, Inflammation, Sleep Assessment • Oversee research development of 2 Mind-Body Clinical Scholars: Drs. Glick and Yanowitz • Mind-Body Visiting Scholars—Emotion regulation and expression • Present new findings in annual School of Medicine Research Symposia, annual Behavioral Medicine Poster Session, and other forums

20. Training: Summer Institutes • Annual 4-day Summer Institutes • Disease etiology, basic psychobiological pathways (Baum and Matthews) • Clinical interventions for diseased/ill populations (Helgeson and Levine) • Profile of applicants from last year • 63 applicants internationally (32 accepted; 1/3 local) • Range of disciplines represented: Medicine (20) Nursing (6) Psychology (32) Public Health (3) Anthropology (1) Clergyman (1)

21. Current Pilot Projects • Functional imaging of SES (Gianaros) • Measurement of hot flashes across ethnic groups (Thurston) • Metabolic, neuroendocrine, and immune function in depression (Cyranowski) • Biofeedback for migraines: Mechanisms (Glick) • Impact of stress on obstetric and neonatal outcomes among women with preterm premature rupture of fetal membranes (Yanowitz)

22. Current Pilot Projects (cont) • CHD risk perceptions in Type 2 diabetes (Klein) • Chronic stress, glucocorticoid resistance and inflammatory process (Marsland) • Feasibility study of long-term adjustment in women treated for breast cancer (Scheier) • Psychosocial factors influencing regional adiposity in postmenopausal women (Conroy) • Genotyping in HeartSCORE: IL6, depression, and inflammation (Halder)

23. Agenda • What should PMBC encourage in M-B science in areas of burdens and resources and psychological, behavioral, and biological pathways? • What new initiatives should we develop in training? • What new structures and mechanisms should we use to promote M-B science in the short and long term?

24. Format • Questions provided to guide discussion but it is not necessary to cover all • Brief presentation followed by a dialogue with interlocutors • Identified EAB member to begin response to discussion and to write 1-2 page summary of recommendations for PMBC faculty and NHLBI program staff

25. What is an interlocutor? • French origin – inter (between) loqui (speak) • #1 One who is having a dialogue • #2 Man in the middle of a line in a minstrel show who questions the end (wo)men and acts as a leader • #3 As applied to law, not final or definitive, made during the progress of an action

26. Format • Questions provided to guide discussion but it is not necessary to cover all • Brief presentation followed by a dialogue with interlocutors • Identified EAB member to begin response to discussion and to write 1-2 page summary of recommendations for PMBC faculty and NHLBI program staff