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LIPID ANABOLISM

LIPID ANABOLISM. acetyl-CoA carboxylase. fig 21-1. acetyl-CoA carboxylase. fig 21-1. acetyl-CoA carboxylase. fig 21-1. condensation. fig 21-2. reduction. fig 21-2. dehydration. fig 21-2. reduction. fig 21-2. synthesis of fatty acids…. fig 21-4. synthesis of fatty acids….

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LIPID ANABOLISM

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  1. LIPID ANABOLISM

  2. acetyl-CoA carboxylase fig 21-1

  3. acetyl-CoA carboxylase fig 21-1

  4. acetyl-CoA carboxylase fig 21-1

  5. condensation fig 21-2

  6. reduction fig 21-2

  7. dehydration fig 21-2

  8. reduction fig 21-2

  9. synthesis of fatty acids… fig 21-4

  10. synthesis of fatty acids… fig 21-4

  11. acyl carrier protein (ACP) in E. coli a lot like… fig 21-4

  12. coenzyme A fig 16-3

  13. AcCoA-ACP transacetylase (AT) fig 21-6 (4th)

  14. malonyl-CoA- ACP transferase (MT) fig 21-6 (4th)

  15. b-ketoacyl-ACP synthase (KS) fig 21-6

  16. b-ketoacyl-ACP reductase (KR) fig 21-6

  17. b-hydroxyacyl-ACP dehydratase (HD) fig 21-6

  18. enoyl-ACP reductase (ER) fig 21-6

  19. acetylCoA-ACP transacetylase (AT) fig 21-6

  20. fig 21-7

  21. fig 21-7

  22. fatty acid synthases variations of the FAS complex fig 21-7

  23. two sources of NADPH… fig 21-9

  24. citrate as a source of building blocks… fig 21-10

  25. citrate lyase as an anabolic carbon source… fig 21-10

  26. and a minor NADPH source… majority supplied by pentose phosphate p.way fig 21-10

  27. Allosteric regulation of fatty acid synthesis fig 21-11

  28. Phosphorylation of fatty acid synthesis active un-phosphorylated ACC makes cytosolic filaments fig 21-11

  29. now what…? elongation desaturation fig 21-12

  30. provided by plants: polyunsat. fatty acids fig 21-14.

  31. cyclooxygenase a key reaction of inflammation in mammals… fig 21-15.

  32. willow bark aspirin: a cycloxygenase inhibitor fig 21-15.

  33. a family of COX inhibitors: NSAIDs box 21-2

  34. a family of COX inhibitors: NSAIDs box 21-2

  35. Two COX isozymes COX1 gastric functions COX2 inflammation pain fever box 21-2

  36. COX2-specific inhibitors box 21-2

  37. COX2-specific inhibitors

  38. COX2-specific inhibitors

  39. lipid menagerie phospholipid triglyceride

  40. phospholipids or glycerophospholipids phophatidylcholine phophatidylserine

  41. mobilizing glycerol fig 21-17.

  42. adding acyl groups phosphatidic acid a phospholipid fig 21-17.

  43. more phospholipids or glycerides… fig 21-18.

  44. anatomy of a phospholipid fig 21-23.

  45. another trinucleotide- based carrier: CTP

  46. fig 21-24.

  47. The isoprene unit: a branched lipid structure

  48. fig 21-32

  49. four stages of cholesterol synthesis fig 21-33

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