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”Veteallergi” Vad är omega-5-gliadin?

”Veteallergi” Vad är omega-5-gliadin?. Professor/överläkare Marianne van Hage Enheten för klinisk immunologi och allergi Avd. för klinisk immunologi och transfusionsmedicin Karolinska Institutet och Universitetssjukhuset Stockholm. Wheat allergens.

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”Veteallergi” Vad är omega-5-gliadin?

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  1. ”Veteallergi”Vad är omega-5-gliadin? Professor/överläkare Marianne van Hage Enheten för klinisk immunologi och allergi Avd. för klinisk immunologi och transfusionsmedicin Karolinska Institutet och Universitetssjukhuset Stockholm

  2. Wheat allergens • Water/salt-soluble albumin/globulin fraction • Amylase/trypsin inhibitor family • Belong to the most prevalent allergens • Responsible for the classic wheat allergy

  3. Wheat allergens • Water/salt-insoluble gluten • Involved in WDEIA (wheat-dependent exercise-induced anaphylaxis) • Of importance in wheat IgE-mediated food allergy

  4. -5 gliadin – Tri a 19 • A major allergen among water/salt-insoluble proteins • Major allergen in WDEIA • ImmunoCAP f416 contains a recombinant peptide representing the immuno-dominant part of -5 gliadin

  5. Innehåll Föreläsningen kommer att beskriva olika veteallergen med fokus på vetekomponenten omega-5 gliadin. Anafylaxi utlöst i samband med veteintag och fysisk ansträngning (Wheat-Dependent Exercise-Induced Anaphylaxis) kommer att diskuteras. Nyttan av att använda omega-5 gliadin vid diagnostik av WDEIA beskrivs. • Inomata N. Wheat allergy. Curr Opin Allergy Clin Immunol. 2009 Jun;9(3):238-43. Review. • Jacquenet S et al. Interest of ImmunoCAP system to recombinant omega-5 gliadin for the diagnosis of exercise-induced wheat allergy. Int Arch Allergy Immunol. 2009;149(1):74-80. • Matsuo H et al. Sensitivity and specificity of recombinant omega-5 gliadin-specific IgE measurement for the diagnosis of wheat-dependent exercise-induced anaphylaxis Allergy. 2008 Feb;63(2):233-6

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