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T-Cell Receptor Signaling

This comprehensive overview details the intricate signaling pathways involved in T-cell receptor (TCR) activation, highlighting the roles of molecules like Ca2+, CD4/CD8, ZAP70, and CTLA4 in immune response and cell differentiation. The interaction of signaling proteins such as TRIM, GRB2, SHP2, Akt, and NF-kB unveils the complexity of cellular proliferation and the translocation of CTLA4 to the membrane. Understanding these pathways is critical for developing targeted therapies in immunology and cancer treatment.

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T-Cell Receptor Signaling

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  1. LAT B7-2 CaCn B7-1 MHC-II TRIM PAG Ag GRB2 GADS CD4/CD8 CD45 SLP76 CD28 ZAP70 Lck PKC SIT CTLA4 SOS SHP2 SHP2 PI3K Caln VHR MEK1/2 CARD11 Fyb PLCg P IkB BCL10 MAP3Ks Fyn Fyn PAK Calm ITK JNK CSK Akt p38 Raf1 IKKs P P P P P P P P P P ERK1/2 IP3R MEKK1 MKK3/6 IkBDegradation SRF MKK4/7 MALT1 NF-kB NF-kB NFAT NFAT NFAT CTLA4 CTLA4 2009 ProteinLounge.com Vav ATF2 c-Jun Rac Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Elk1 Text Text Ras Antigen-Presenting Cell CaCn PIP2 DAG TCR-CD3Complex T-Cell Receptor Signaling Cell Proliferationand Differentiation CDC42 Active Release andTranslocation of CTLA4 to Membrane IP3 CytoskeletalRemodelling CTLA4 Endosome ImmuneResponse C IL-2 GeneExpression

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