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Human Endocrine Physiology

This comprehensive overview explores fundamental concepts in human endocrine physiology, focusing on sex determination, the SRY gene, testicular steroid pathways, and hormonal regulation during the menstrual cycle. It details the role of various hormones, including LH, FSH, and steroid hormones such as testosterone, cortisol, and estrogen. Key mechanisms like the conversion of testosterone to dihydrotestosterone and the impact of congenital adrenal hyperplasia are discussed. Additionally, insights into hormonal fluctuations across the menstrual cycle are provided, highlighting the interplay between the hypothalamus, pituitary, and ovaries.

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Human Endocrine Physiology

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  1. Human Endocrine Physiology February 27, 2014

  2. Sex Determinationand Differentiation

  3. SRY

  4. SRY AMH T

  5. SRY Gene

  6. Testicular Steroid Pathways LH/FSH Cholesterol Pregnenolone 17OH-Preg Progesterone 17OH-Prog A4 T

  7. Conversion of Testosteroneto Dihydrotestosterone

  8. SRY AMH T

  9. Conversion of Testosteroneto Dihydrotestosterone

  10. Adrenal Steroid Pathways ACTH Cholesterol Pregnenolone 17OH-Preg DHEA Progesterone 17OH-Prog Androstenedione Testosterone Cortisol Aldosterone

  11. Classical Congenital Adrenal Hyperplasia ACTH Cholesterol Pregnenolone 17OH-Preg DHEA Progesterone 17OH-Prog Androstenedione * * Testosterone Cortisol Aldosterone *21-hydroxylase loss of function mutation

  12. Classical Congenital Adrenal Hyperplasia ACTH Cholesterol Pregnenolone 17OH-Preg DHEA Progesterone 17OH-Prog Androstenedione * * Testosterone Cortisol Aldosterone *21-hydroxylase loss of function mutation

  13. Human Endocrine Physiology:The Menstrual Cycle

  14. Ovarian Physiology GnRH Pituitary LH FSH Inhibin Estrogens Ovary Progesterone Androgens

  15. Gonadotropin Releasing Hormone (GnRH) (hypothalamus) + (pituitary) Sex steroid Inhibin* - (+) LH FSH + (ovary) *Inhibin exerts negative feedback only at the pituitary and only on FSH

  16. Insulin

  17. Ovarian Steroid Pathways LH/FSH Cholesterol Pregnenolone 17OH-Preg Progesterone 17OH-Prog A4 Estrone Estradiol T

  18. * * *Only enzyme to know

  19. Changes in HormonesAcross the Menstrual Cycle FSH 0 Ov 30

  20. Changes in HormonesAcross the Menstrual Cycle Estradiol 0 Ov 30

  21. Changes in HormonesAcross the Menstrual Cycle LH 0 Ov 30

  22. Changes in HormonesAcross the Menstrual Cycle Progesterone 0 Ov 30

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