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Jesse arrives at the clinic, he is 14 months old

Jesse arrives at the clinic, he is 14 months old. Though he looks normal in many respects his parents are worried about him . Developmental milestones 1-2. Knows a few parts of the body and can point to them when asked YES NO

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Jesse arrives at the clinic, he is 14 months old

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  1. Jesse arrives at the clinic, he is 14 months old Though he looks normal in many respects his parents are worried about him

  2. Developmental milestones 1-2 Knows a few parts of the body and can point to them when asked YES NO Follows simple commands (“Roll the ball”) and understands simple questions (“Where’s your shoe?”) YES NO Enjoys simple stories, songs, and rhymes YES NO Points to pictures, when named, in books YES NO Acquires new words on a regular basis YES NO Uses some one- or two-word questions (“Where kitty?” or “Go bye-bye?”) YES NO Puts two words together (“More cookie” or “No juice”) YES NO Uses many different consonant sounds at the beginning of words

  3. Attention deficit disorder drugs Ritalin is a mild central nervous system stimulant. It affects chemicals in the brain that contribute to hyperactivity and impulse control.

  4. Jesse’s brain on autopsy Normal brain

  5. Coronal section Normal brain

  6. Positron Emission Tomography (PET) 18Fluorodeoxyglucose Half life = 110 minutes PET scanner

  7. Positron Emission Tomography (PET) Horizontal sections Normal brain Area of abnormal Activity (seizure)

  8. Positron Emission Tomography (PET) Horizontal sections Normal brain Area of abnormal activity in Alzheimer’s patient

  9. Positron Emission Tomography (PET) Horizontal sections Area of abnormal activity (seizure) Brain showing tumor

  10. MAGNETIC RESONANCE IMAGING (MRI) Hydrogen atom MRI scanner

  11. FUNCTIONAL MAGNETIC RESONANCE IMAGING (fMRI) Hemoglobin: Oxygenation changes Fe 2+ to Fe 3+ MRI scanner

  12. MAGNETIC RESONANCE IMAGING (MRI) Corpus callosum Structural MRI Functional MRI (Subject read one word)

  13. MAGNETIC RESONANCE IMAGING (MRI) Tumor Agenesis of the corpus callosum

  14. Electroencephalopathy (EEG) Amplifier Cap Leads

  15. Electroencephalopathy (EEG) Neurons responsible For the signal Parietal area between electrodes

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