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MSH

MSH. melanocyte- stimulating hormone. melanophore- stimulating hormone. Dwi Winarni Departemen Biologi Fakultas Sains dan Teknologi Universitas Airlangga 2009.

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MSH

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  1. MSH melanocyte- stimulating hormone melanophore- stimulating hormone Dwi Winarni Departemen Biologi Fakultas Sains dan Teknologi Universitas Airlangga 2009

  2. ACTH=adrenocorticotropic hormone, LPH=Lipotropin, AL=anterior lobe, IL=intermediate lobe, CLIP=corticotropin-like intermediate lobe peptide. a,b, dan g MSH bersama-sama disebut sebagai melanotropin atau intermedin

  3. MSH adalah hormon yang dihasilkan hipofisis lobus intermediat

  4. MSH meningkatkansintesis melanin (padamelanosit) danpadamelanophore (melanofora) jugamengakibatkandispersimelanosoma Melanin dapat ditemukan terutama di kulit, rambut, mata, sisik, bulu dan kutikula hewan Melanosoma adalah organel yang mensintesis dan menyimpan melanin dan pada melanosit di epidermis mamalia, berperan juga sebagai organel yang dapat “mensekresikan” melanin

  5. contains brown red pigment contains brown black pigment =sel penghasil pigmen coklat hitam (melanin)

  6. Schematic outline of the metabolic pathway leading to melanin formation in mammals Biochemical Journal (1997) Volume 323, 749-756 UV increases melanogenesis

  7. .The four stages of melanosome development of MNT-1 human melanoma cells are shown in the upper panels. Note the dense bilayered coat (arrowhead) and intralumenal vesicles (arrow) of stage I melanosomes, the proteinaceous fibrils (arrow) of stage II, and the melanin deposition (black) in stages III and IV. The main panel shows a typical field of MNT-1 cytoplasm near the nucleus, which contains all four stages of melanosomes. M, mitochondria; N, nucleus. Scale bar represents 0.5 m m.

  8. Schematic diagram of the late secretory and endosomal systems, emphasizing the best characterized compartments found in a | all cell types or b | melanocytes. Secretory granules, present in only certain cell types, are also indicated in a. Arrows represent proposed directions of protein and lipid transport between organelles. 'Spikes' indicate clathrin coats; the dense clathrin-containing coat of the coated endosome in melanocytes is also indicated by black shading, as this probably contains additional components. Intralumenal vesicles are present in late endosomes and coated endosomes, as indicated by small circles; irregularly shaped intralumenal membranes tend to be present in lysosomes. The intralumenal striations of stage II and III melanosomes are indicated. In b, potential sites of action of certain proteins are also indicated. CHS, Chediaki Higashi syndrome; HPS, Hermansky–Pudlak syndrome; TGN, trans-Golgi network; AP-1/AP-3, adaptor complexes

  9. HPS, Hermansky–Pudlak syndrome;

  10. Melanocytes are cells located in the bottom layer (the stratum basale) of the skin's epidermis, and in the middle layer of the eye (the uvea). In the skin, melanin are transferred to keratinocytes

  11. MELANOFORA (MELANOPHORE) MSH dispersed aggregated Pada berbagai invertebrata dan cold-blooded vertebrates

  12. melanofora pada sisik Teleostei pigmentsaggregated pigmentsdispersed

  13. A mutant zebrafish larva that fails to synthezise melanin in its melanophores, beneath a non-mutant, wildtype larva

  14. melanoforaumumnyaberadabersama-samadengankromatofora lain a.l. • Xanthophore •  mengandungpigmenkuning • 2. Erythrophore •  mengandungpigmenmerah • 3. Leucophore •  pigmenputih • 4. Cyanophore •  biru • 3. Iridophore/ guanophore •  mengandung reflecting plateles yang merupakankristalguanin

  15. Urutanlapisankromatoforapadakulitkatakhijau

  16. dark A single zebrafish melanophore imaged by time-lapse photography during pigment aggregation light

  17. Dendrobates pumilio, a poison dart frog. Some brightly colored species have unusual chromatophores of unknown pigment composition

  18. Chromatophores  contain yellow and red pigments . Reflected incident light becomes the blue, yellow, green (blue plus yellow). A layer of dark melanin influences  the 'lightness' of the reflected light. All these pigment cells can rapidly relocate their pigments, thereby influencing the colour of the chameleon.

  19. Sekresi MSH dipengaruhi oleh:Cahaya  lewat fotoreseptor  terang-agregasi • Selainoleh MSH, melanoforadipengaruhioleha.l. • Katekolamin •  stimulasireseptor a-adrenergikkarenafaktor stress akutmengakibatkan “excitement pallor” karenaterjadiagregasi • 2. Kadar cAMPintrasel

  20. Lobusintermediatpadamamaliamengalamidegenerasi • MSH ??? • Pigmentasi ???

  21. Series concept: Simple & perfect whitening by marine complex Our skin is always damaged by UV, smoke, stress and this damage increases the abnormal melanogenesis and irregular turnover. The result is pigmentation and skin aging are accelerated and the skin loses its transparency and gets freckles. 2 marine complexes work to keep your skin healthy and to make your skin brighter:

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