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From ancient TCM to modern drug discovery: a successful story

From ancient TCM to modern drug discovery: a successful story. 5.12.2008 Prof. Antti Poso Dept. of Pharmaceutical Chemistry University of Kuopio. China. Pen Ts'ao Ching (Classic of Materia Medica) Emperor Shen Nung Founder of Traditional Chinese Medicine, TCM. Abu Bakr al-Razi (Rhazes).

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From ancient TCM to modern drug discovery: a successful story

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  1. From ancient TCM to modern drug discovery: a successful story 5.12.2008 Prof. Antti Poso Dept. of Pharmaceutical Chemistry University of Kuopio

  2. China.... • Pen Ts'ao Ching (Classic of Materia Medica) • Emperor Shen Nung • Founder of Traditional Chinese Medicine, TCM

  3. Abu Bakr al-Razi (Rhazes) • Head of the Baghdad main hospital, 865-925 • Two main work dealing with drug substances and herbs, • Kitab al-Hawi fi altibb, 10 vol, (Comprehensive Book of Medicines) translated to Latin around year 1140 • Combined the knowledge and information from Greece, Roman Empire, Egypt, India and in some extent also from China

  4. A modern aproach • Abu Bakr al-Razi used • opium before surgery • He also used animals to test the effects of new herbs/medicines before testing with patients • Smallpox, allergies, fewer, pharmacy, ethics of medicine

  5. Malaria • Jesuit priest learned the effects of Cinchona (quina-quina) from South-American indians around 1630 • Cardinal Juan de Lugo and later the Pope supported the research • Robert Talbor created a standardized preparation, and he was granted a priviledge by the Luis XIV • The recipe was published after Talbor death 1681

  6. Ipecacuanha • Powerful against amoebic dysentery • In Europe first time1672 • Again Louis XIV granted a sole right for one person (Helvetius), but the recipe was published 1688 • A one, single conclusion started after these findings.....

  7. 34 % of small molecule NCEs natural products

  8. Harvey, A. L. Drug. Discov. Today.2008, in press

  9. Property distribution

  10. Advantages of natural compounds? • databases of natural compounds contain proportionally more bioactive molecules? • natural compounds are supposed to have better ADMET-properties • they are easily absorbed or metabolized by the body • 40 % of chemical scaffolds published in natural databases are absent from synthetic chemistry • of the NCE between 1981-2001 • 42 % were natural products or their derivatives • 60-80% of antibacterials and anticancer drugs derived from natural products

  11. TCM • three thousand years of ”clinical tests” • documentation • it is assumed that bioactive molecules are concentrated within TCM-database • TCM products are a source for tens of thousands of natural compounds

  12. Dockingstudies • (FAAH) • human fatty acid amide hydrolase • in-house testing system • docking of selected molecules to FAAH • GOLD • modified parameters to enhance binding mode

  13. SRF-7 SRF-4 SRF-8

  14. SORRY, NO FORMULAS

  15. Future aspects • In silico studies • human sirtuins (SIRT1 and SIRT2) • human cannabinoid system • selected compounds for in vitro test • other targets of interest

  16. Acknowledgements • Dr. Tuomo Laitinen • M.Sc. Heikki Käsnänen • M.Sc. Sanni Matero • M.Sc. Tuomo Kalliokoski • PMC Group • ISB • Tekes • CSC – Finnish IT Center for Science

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