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Fig. 11-CO, p.264

Fig. 11-CO, p.264. Learning Objectives. How Does Transcription Take Place in Prokaryotes? How Is Transcription Regulated in Prokaryotes? How Does Transcription Take Place in Eukaryotes? How Is Transcription Regulated in Eukaryotes? How Is RNA Modified after Transcription?

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Fig. 11-CO, p.264

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  1. Fig. 11-CO, p.264

  2. Learning Objectives • How Does Transcription Take Place in Prokaryotes? • How Is Transcription Regulated in Prokaryotes? • How Does Transcription Take Place in Eukaryotes? • How Is Transcription Regulated in Eukaryotes? • How Is RNA Modified after Transcription? • How Does RNA Act as an Enzyme?

  3. Table 11-1, p.265

  4. The basics of transcription Fig. 11-1, p.265

  5. Sequence of representative promoters from E.coli Fig. 11-2, p.266

  6. Sequence of events in the initiation & elongation phases of transcription in prokaryotes Fig. 11-3, p.268

  7. Inverted repeats terminate transcription Fig. 11-5, p.269

  8. The rho(p)factor mechanism of transcription termination Fig. 11-6, p.270

  9. Control of transcription via different σ subunit c Fig. 11-7, p.271

  10. Elements of a bacterial promoter Fig. 11-8, p.271

  11. The mode of acion of the lac repressor Fig. 11-9, p.273

  12. Basic control mechanisms seen in the control of genes Fig. 11-12, p.275

  13. The attenuation mechanism in the trp operon Fig. 11-15, p.277

  14. Summary of eukaryotic transcription • It is more complicated than prokaryotic transcription • 3 RNA polymerases of which Pol II produces mRNA • The organization of promoters & enhancers is more complicated • An impoatant element is TATA box at -25 • 6 general initiation factors are involved in forming the initiation complex

  15. F Four elements of polymerase II promoters in eukaryotes Fig. 11-17, p.280

  16. DNA looping brings enhancers in contact with transcription factors and RNA polymerase Fig. 11-20, p.285

  17. Table 11-4, p.286

  18. Activation of transcription via CREB & CBP Fig. 11-21, p.286

  19. Multiple ways in which CREB binding protein (CBP) and p300 are involved in gene expression Fig. 11-22, p.287

  20. Table 11-5, p.287

  21. Posttranscriptional modification of a tRNA precursor Fig. 11-30, p.292

  22. The organization of split genes in eukaryotes Fig. 11-33, p.294

  23. Splicing of mRNA precursors ( a lariat forms in the intron ) Fig. 11-34, p.295

  24. Organization of the fast skeletal muscle troponin T gene and the 64 possible mRNAs that can be generated from it The exons in blue and red are exclusive .only one or the other may be used Fig. 11-35, p.296

  25. SLE : Systemic lupus erythematosus is an auto immune disease Production of a.b. to one of the snRNPs,U1-snRNP Rash on the forehead & cheek bones, giving the wolf like appearance. Severe kidney damage may follow with arthritis, accumulation of fluid around the heart, & inflammation of the lungs. L SLE p.296

  26. END Chapter 11

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