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Chap 48 -Substance P and endorphin

Chap 48 -Substance P and endorphin . B9902014 吳瑞當 B9902050 郭柏彥. endorphin. Substance P. Introduction. Substance P(SP) released from the terminals of sensory nerve cells of skin and joints a kind of neurotransmitter transmits pain information to the CNS

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Chap 48 -Substance P and endorphin

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  1. Chap 48 -Substance P and endorphin B9902014 吳瑞當 B9902050 郭柏彥 endorphin Substance P

  2. Introduction • Substance P(SP) • released from the terminals of sensory nerve cells of skin and joints • a kind of neurotransmitter • transmits pain information to the CNS • the receptor is NK1(GPCR). • controlls emotion.

  3. Endorphins (endogenous morphine) • morphin produced naturally in the body • hypothalamic neurons generate and pituitary gland release • a cleavage product of pro-opiomelanocortin (POMC) • the precursor hormone for adrenocorticotrophic hormone (ACTH) • μ opioid receptors are the main receptor 3.modulating pain, cardiac, gastric, vascular function, panic and satiation • inhibit the release of the inhibitory neurotransmitter GABA • disinhibit the dopamine pathways • causing more dopamine to be released and cause inappropriate dopamine release, which causes addiction

  4. Stimuli for Substance P secretion • mood disorders, anxiety, stress, reinforcement, neurogenesis, respiratory rhythm, neurotoxicity, nausea/emesis, painand nociception. • Stimuli for endorphins secretion • Strenuous exercise, Excitement, Pain, DeathOrgasm, Over exposure to sun, Spicy food

  5. Endorphins’Activity • Relaxation profound relaxation in a float tank triggers the production of endorphins,which explains the pain relief experienced during float sessions. • Acupuncture • inserting acupuncture needles into specific body points triggers the production of endorphins • higher levels of endorphins were found in cerebrospinal fluid

  6. Endorphins’ Activity • Pregnancy A placental tissue of foetal origin(the syncytiotrophoblast)excretes beta-endorphins into the maternal blood system from the 3rd month of pregnancy. Foetuses make their mothers endorphin-dependent then manipulate them to increase nutrient allocation to the placenta.

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