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Ledipasvir + Sofosbuvir +/- Ribavirin in GT 1-3 ELECTRON 2

Phase 2. Treatment Naïve and Treatment Experienced. Ledipasvir + Sofosbuvir +/- Ribavirin in GT 1-3 ELECTRON 2. Source: Gane EJ, et al. 49 th EASL. 2014 : Abstract O6. Sofosbuvir-Ledipasvir +/- Ribavirin in GT 1 & 3 ELECTRON 2 Trial : Features.

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Ledipasvir + Sofosbuvir +/- Ribavirin in GT 1-3 ELECTRON 2

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  1. Phase 2 Treatment Naïve and Treatment Experienced Ledipasvir + Sofosbuvir +/- Ribavirin in GT1-3ELECTRON 2 Source: Gane EJ, et al. 49th EASL. 2014: Abstract O6.

  2. Sofosbuvir-Ledipasvir +/- Ribavirin in GT 1 & 3ELECTRON 2 Trial: Features Source: Gane EJ, et al. 49th EASL. 2014: Abstract O6.

  3. Sofosbuvir-Ledipasvir +/- Ribavirin in GT 1 & 3ELECTRON 2: Study Design 0 12 24 Week GT1Prior Sofobuvir n =19 SVR12 LDV-SOF + RBV GT1CTP Class B SVR12 n = 20 LDV-SOF GT3Treatment NaïveRandomized n = 25 SVR12 LDV-SOF SVR12 LDV-SOF + RBV n = 26 Abbreviations: LDV-SOF = ledipasvir-sofosbuvir; RBV = ribavirin Drug DosingLedipasvir-sofosbuvir (90/400 mg): fixed dose combination; one pill once dailyRibavirin (weight-based and divided bid): 1000 mg/day if < 75 kg or 1200 mg/day if ≥ 75 kg Source: Gane EJ, et al. 49th EASL. 2014: Abstract O6.

  4. Sofosbuvir-Ledipasvir +/- Ribavirin in GT 1 & 3ELECTRON-2: Baseline Characteristics Source: Gane EJ, et al. 49th EASL. 2014: Abstract O6.

  5. Sofosbuvir-Ledipasvir +/- Ribavirin in GT 1 & 3ELECTRON 2: Study Design SVR 12, by GT and Treatment Regimen 19/19 13/20 16/25 26/26 SOF-Experienced CTP Class B Treatment Naive LDV-SOF = ledipasvir-sofosbuvir; RBV = ribavirin Source: Gane EJ, et al. 49th EASL. 2014: Abstract O6.

  6. This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Onlinewww.hepatitisc.uw.edu Hepatitis Web Studyhttp://depts.washington.edu/hepstudy/ Funded by a grant from the Centers for Disease Control and Prevention.

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