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plasma

K 1. k 7. K 5. k 3. k 2. k 8. k 6. k 4. Full 6-compartments. injection. t=0. V. IV. plasma. II. III. K 9. urine. K 1. K 2. Extracellular Fluid (ECF). injection. t=0. plasma. ECF. K 9. urine. K 1. K 5. k 2. k 6. Slow Space. injection. t=0. plasma. ECF. slow. K 9.

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plasma

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  1. K1 k7 K5 k3 k2 k8 k6 k4 Full 6-compartments injection t=0 V IV plasma II III K9 urine

  2. K1 K2 Extracellular Fluid (ECF) injection t=0 plasma ECF K9 urine

  3. K1 K5 k2 k6 Slow Space injection t=0 plasma ECF slow K9 urine

  4. K5 K1 k6=0 k2=0 Blood Flow injection t=0 tissue1 tissue2 blood K9 urine

  5. kon1 kon5 KD2 KD6 Single Volume injection t=0 bound2 free bound1 k9 metab

  6. K1 kon3 kon7 K5 KD4 k2 KD8 k6 Two Tissues injection t=0 recept2 tissue2 ECF tissue1 recept1 K9 urine

  7. kon3 K1 KD4 k2 Receptor Plus Non-specific Binding injection t=0 plasma tissue receptor K9 kon7 KD8 non-spec urine

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