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Louisiana NCRR / IDeA 2010 Biomedical Research Symposium

COBRE. INBRE. RCMI. Louisiana NCRR / IDeA 2010 Biomedical Research Symposium. Bio-Medical Research. TNPRC. CTSA. January 22, 2010. Genesis of the Symposium. 2007 Success Story of Louisiana CoBRE/INBRE – Drs. Bazan and Fidel NAIPI 2007 Dr. Kousoulas LA CaTS – 2009 Dr. Ryan

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Louisiana NCRR / IDeA 2010 Biomedical Research Symposium

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  1. COBRE INBRE RCMI Louisiana NCRR / IDeA 2010 Biomedical Research Symposium Bio-Medical Research TNPRC CTSA January 22, 2010 Louisiana Biomedical Research Network

  2. Genesis of the Symposium 2007 Success Story of Louisiana CoBRE/INBRE – Drs. Bazan and Fidel NAIPI 2007 Dr. Kousoulas LA CaTS – 2009 Dr. Ryan Southeast IDeA Regional Meeting 2009 Louisiana Biomedical Research Network

  3. The Need in Louisiana (United Health Foundation-2009) Louisiana is 47th in overall Health rankings Health Disparities are High Obesity & Diabetes Cardiovascular Disease Cancer Infectious Disease Neurologic Disease Louisiana Biomedical Research Network

  4. Purpose COBRE INBRE RCMI Bio-Medical Research TNPRC CTSA To highlight the research progress of the Louisiana NCRR/IDeA network, demonstrate group relationships and to promote collaboration and interaction among this community in the future. Louisiana Biomedical Research Network

  5. Louisiana Biomedical Research and the NCRR COBRE INBRE RCMI Bio-Medical Research NCRR Divisions Institutional Development Awards Research in Minority Institutions Comparative Medicine Clinical Research There is exceptional value in this support TNPRC CTSA Louisiana Biomedical Research Network

  6. Biomedical Research Funding in Louisiana (Millions 2007) Clinical Research - NIH $37.9, Other $59.5 Research- NIH $131.3, Other $78.1 Education/Training- NIH $20.2, Other $8.5 Total - NIH $155.6, Other $ 96.4, Total - $251.9 Biomedical Research in Louisiana is Growing Louisiana Biomedical Research Network

  7. State Support of Biomedical Research Infrastructure - millions TNPRC $10 LA Cancer Research Consortium $38 LONI Computer Network $15 Data Center $24 Wet Lab Incubators (NO, BR, SP) $50.5 PBRC Clinical Bldg $21 Louisiana Biomedical Research Network

  8. State Support of Biomedical Research – Centers (millions) LA CaTS- $5.9 Tulane Hypertension and Renal Center - $3.5 LA Peptide Translational Research Consortium-$3.9 South LA Institute for Infectious Disease-$3.9 Center for Excellence in Vaccine Development- $5.5 LONI Institute- $7 INBRE LBRN- $1.2 The State has made significant investments which are paying dividends in biomedical research. Louisiana Biomedical Research Network

  9. Biomedical Research Intensive Institutions • Louisiana State University (LSU) • LSU System- PBRC • LSU Health Sciences Center in New Orleans (LSUHSC-NO) • LSU Health Sciences Center in Shreveport (LSUHSC-S) • Tulane Medical Center (TMC) • Tulane National Primate Research Center (TNPRC) Louisiana Biomedical Research Network

  10. COBREs • LSU and A&M College & Tulane National Primate Research Center • School of Veterinary Medicine (SVM) • Center for Experimental Infectious Disease Research (Kousoulas) • LSU System • Pennington Biomedical Research Center (PBRC) • Mentoring Obesity and Diabetes Research in Louisiana (Gettys) • LSUHSC in New Orleans • Mentoring in Cardiovascular Biology (Kapusta) • Mentoring Neuroscience in Louisiana (Bazan) • Mentoring Translational Researchers in Louisiana (Ochoa) • Mentoring Oral Health Research in Louisiana (Fidel) • LSUHSC in Shreveport • Center for Molecular and Tumor Virology (O’Callaghan) • Tulane Medical Center (TMC) • Mentoring a Cancer Genetics Program (Deininger) • Tulane Hypertension and Renal Center of Excellence (Navar) Louisiana Biomedical Research Network

  11. COBRE INBRE RCMI Louisiana INBRE Bio-Medical Research TNPRC CTSA Louisiana Biomedical Research Network LBRN Louisiana Biomedical Research Network

  12. INBRE - Louisiana Biomedical Research Network (LBRN) • Lead Institution: • LSU Louisiana Biomedical Research Network

  13. INBRE with affiliated Institutions: • Lead Institution: • LSU and A&M College • Primarily Undergraduate Institutions (PUIs): • LSU in Shreveport (LSU-S) • Louisiana Tech University (LA Tech) • Southern University and A&M College (SU) • University of Louisiana at Monroe (ULM) • Xavier University of Louisiana Louisiana Biomedical Research Network

  14. INBRE with Affiliated Institutions: • Lead Institution: • LSU and A&M College • Primarily Undergraduate Institutions (PUIs): • LSU in Shreveport (LSU-S) • Louisiana Tech University (LA Tech) • Southern University and A&M College (SU) • University of Louisiana at Monroe (ULM) • Xavier University of Louisiana • Mentor Campus: • LSUHSC in New Orleans (LSUHSC-NO) • LSUHSC in Shreveport (LSUHSC-S) • Pennington Biomedical Research Center (PBRC) • Tulane Medical Center • Tulane National Primate Research Center (TNPRC) • LSU Louisiana Biomedical Research Network

  15. INBRE with affiliated Institutions: • Lead Institution: • LSU and A&M College • Primarily Undergraduate Institutions (PUIs): • LSU in Shreveport (LSU-S) • Louisiana Tech University (LA Tech) • Southern University and A&M College (SU) • University of Louisiana at Monroe (ULM) • Xavier University of Louisiana • Mentor Campus: • LSUHSC in New Orleans (LSUHSC-NO) • LSUHSC in Shreveport (LSUHSC-S) • Pennington Biomedical Research Center (PBRC) • Tulane Medical Center • Tulane National Primate Research Center • Summer Research Program Campus: • Baton Rouge Community College (BRCC) • Centenary College • Dillard University • Grambling State University • Louisiana College (LA College) • Loyola University • LSU-Alexandria (LSU-A) • LSU-Eunice (LSU-E) • McNeese State University • Our Lady of Holy Cross College (OLHCC) • Our Lady of the Lake College (OLOLC) • Nicholls State University • Northwestern State University (NSU) • Southeastern Louisiana University (SELU) • Southern University at New Orleans (SUNO) • Southern University at Shreveport (SUS) • Tulane University • University of Louisiana at Lafayette (ULL) • University of New Orleans (UNO) Louisiana Biomedical Research Network

  16. Historically Black Colleges and Universities (HBCUs) • Dillard University • Grambling State University • Southern University and A&M College (SU) • Southern University at New Orleans (SUNO) • Southern University at Shreveport (SUS) • Xavier University of Louisiana Louisiana Biomedical Research Network

  17. COBRE INBRE RCMI Bio-Medical Research TNPRC CTSA The LBRN is functionally linked to all NCRR Funded Programs in the State Louisiana Biomedical Research Network

  18. LBRN Overall Goals 2010-2015 Build the Biomedical Research Capacity of the state - Infrastructure Build the Intellectual Research Base at PUIs Enhance Biomedical Research Opportunities for Undergraduates Enhance the Biomedical Science and Technology Base - Work force development Louisiana Biomedical Research Network

  19. Accomplishments 2005-2009 Campus research cultures advance Increased AG nodes and use Bioinformatics Core of LSUHSC-S COBRE Bioinformatics PhD degree proposed (LSU-S, La Tech, LSUHSC-S) Bioinformatics Affinity Group formed Individual research participation high, 344 Grants funded, 11 Publications increase, >80 Louisiana Biomedical Research Network

  20. Expanded Network – LONI and Access Grid • HPC- LONI/LSU cluster at 100Teraflops and part of TeraGrid • Increased band width, institutions and end users • AG number increase, 6 to 43 • AG Global Quality Assurance Program, LSU is the US QA site. Louisiana Biomedical Research Network

  21. INBRE Research Thematic Area Distribution (proposed in 2010-2015) CSB MMD Computational & Structural Biology (CSB) Molecular Mechanism of Disease (MMD) Therapeutics and Preventive Medicine (TPM) TPM Louisiana Biomedical Research Network

  22. DNA microarray analysis of the UPII-SV40Tag model for invasive bladder TCC: identification of markers for bladder premalignancy Urska Cvek1, Randolph Stone II2, Anita L. Sabichi3, Jennifer Gill2, I-ling Lee3, Marjan Trutschl1, Rasiah Loganantharaj4, and John L. Clifford2 1 Department of Computer Science, LSU Shreveport, 2 Department of Biochemistry and Molecular Biology, LSUHSC-Shreveport and Feist-Weiller Cancer Center 3 Department of Clinical Cancer Prevention, University of Texas, MD Anderson Cancer Center 4 Center for Advanced Computer Studies, University of Louisiana-Lafayette Louisiana Biomedical Research Network

  23. Overall Research Strategy Biomedical laboratory -animal models (UPII-SV40Tag) -molecular and cell biological studies J. Clifford, LSUHSC-S (Mentor) Computation Urska Cvek, LSU-S -Microarray analysis -Visualization Hypothesis testing Clinical Trials -Phase III Chemoprevention -Biomarker analysis A. Sabichi, MDACC Louisiana Biomedical Research Network

  24. LFC ≥ 2.0 Louisiana Biomedical Research Network

  25. Validation of potential early TCC biomarkers identified from microarray experiments Rhamm expression: urine dot blot Patient samples (-) controls (+) controls 1. 2. 3. 4. Undil. 1:2 1:4 1:8 5. 6. 7. 8. 9. 10. R. Stone, A.L. Sabichi, J. Gill, I-L Lee, R. Loganantharaj, M. Trutschl, U. Cvek, J.L. Clifford. Identification of genes involved in early stage bladder cancer progression, Cancer Prevention Research, 2009 (CAPR-09-0189R1). Patient samples Louisiana Biomedical Research Network

  26. PUI Scientist/Students – Research Intensive Institution - Translational Cvek/Trutchl’s Labs LSU-S Clifford’s Lab LSUHSC-S Louisiana Biomedical Research Network

  27. Students in PUI Laboratories Undergraduates – 85 Graduate Students – 71 Grey Lab, PhD students-Kelly Boyle, Lakesha De Bose, Postdoc-Dr. Shiresha Sankella Hsia Lab, Postdoc-Dr. Rajesh Pinnoji, Most students move on to the next stage of career development Dua Lab, Postdoc-Dr. Pradeep Chowriappa, PhD students, Harpreet Singh, Sheetal Singh, Priti Srinivasan Louisiana Biomedical Research Network

  28. INBRE-LBRN Summer Research Program • Undergraduate Students – 184 • Graduate Students – 44 • Faculty – 45 • 86% of undergraduate have gone on to graduate school, medical school of other professional schools Louisiana Biomedical Research Network

  29. The LBRN has with NIH and State support continued to successfully expand the collaborative nature of biomedical research, research training and workforce development throughout the State. COBRE INBRE RCMI Bio-Medical Research TNPRC CTSA Louisiana Biomedical Research Network

  30. Louisiana Biomedical Research Network

  31. Expanded Network – LONI and Access Grid • HPC- LONI/LSU cluster at 100Teraflops and part of TeraGrid • Increased band width, institutions and end users • AG number increase, 6 to 43 • AG Global Quality Assurance Program, LSU is the US QA site. LA Tech ULM LSU-S LSU SUBR Tulane Louisiana Biomedical Research Network

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