1 / 7

Cardiac Tissue Matrix

Cardiac Tissue Matrix. Katelyn Pate. Statistics. Heart disease and stroke are the 1 st and 3 rd leading cause of death in the U.S. They account for 40% of all deaths, more than all cancer combined Congenital heart defects occur in nearly 14 of every 1000 newborn children

cliff
Télécharger la présentation

Cardiac Tissue Matrix

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Cardiac Tissue Matrix Katelyn Pate

  2. Statistics Heart disease and stroke are the 1st and 3rd leading cause of death in the U.S. They account for 40% of all deaths, more than all cancer combined Congenital heart defects occur in nearly 14 of every 1000 newborn children Most common congenital defect and leading cause of death in first year of life

  3. Why is this Important? • Cardiac tissue has very low regenerative capabilities • Tissue engineering can be used to: • Reconstruct malformed hearts in children • Regenerate failing hearts in adults

  4. Background • 3 Approaches • Administration of liquid-phase cell suspensions • Hydrogel cell delivery via catheters • Contractile cardiac tissue engineered patch

  5. Injection of Cell Suspensions Advantages Disadvantages Very convenient Low engraftment and cell survival

  6. Hydrogel Cell Delivery Advantages Disadvantages Improved cell retention over injection via a syringe Offers customization using growth factors Still low engraftment and cell survival

  7. Cardiac Tissue Engineered Patch Advantages Disadvantages Deliver cells with immediate function and capacity for vascular and electromechanical integration with the heart Difficult to create a scaffold that displays functional and morphological properties of native heart muscles

More Related