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Andrew C. Li and Christopher K. Glass Journal of Lipid Research, Vol 45, 2161-2173, December 2004

Jalur yang Bergantung pada PPAR dan LXR dalam Mengontrol Metabolisme Lipid dan Pembentukan Artherosklerosis. PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis. Andrew C. Li and Christopher K. Glass

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Andrew C. Li and Christopher K. Glass Journal of Lipid Research, Vol 45, 2161-2173, December 2004

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  1. Jalur yang Bergantung pada PPAR dan LXR dalam Mengontrol Metabolisme Lipid dan Pembentukan Artherosklerosis.

  2. PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis Andrew C. Li and Christopher K. Glass Journal of Lipid Research, Vol 45, 2161-2173, December 2004

  3. Tujuan • Mempelajari peranan PPAR dan LXR dalam pembentukan arterosklerosis.

  4. Latar Belakang Proses terbentuknya fatty streak penyebab arterosklerosis : • Endothelial sel terluka • Monositmakrofag • Scavenger receptor mengenali ox-LDL • Ox-LDL+makrofagfoam cell foam cell – VCAM-1 – MCP-1

  5. LXR (Liver X Receptor) • Terdiri dari 2 jenis molekul • LXRα terdapat pada sel hati dan makrofag • LXRβ terdapat pada seluruh jaringan • Keduanya memiliki kesamaan fungsi

  6. PPAR, LXR dan regulasinya

  7. PPAR,LXR dan regulasinya(2)

  8. PPAR,LXR dan regulasinya(3)

  9. Peran LXR

  10. PPAR (Peroxisome Proliferator Activated Receptor)

  11. Kesimpulan • PPARα dan LXR bekerjasama dalam mereduksi [kolesterol] tinggi. • PPARγ dan δ berperan dalam metabolisme lipid.

  12. Terimakasih Atas Perhatiannya

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