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Wound Healing Properties of Honey

Wound Healing Properties of Honey. General effects of honey on wound healing. W ound contraction. Granulation tissue . E pithelialization . Inflammation. Facilitates debridgement. Deodorizes wound. 1.Regeneration. Wound Healing. 2.Repair. 3.Re-vasculalization.

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Wound Healing Properties of Honey

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  1. Wound Healing Properties of Honey

  2. General effects of honey on wound healing Wound contraction Granulation tissue Epithelialization Inflammation Facilitates debridgement Deodorizes wound

  3. 1.Regeneration Wound Healing 2.Repair 3.Re-vasculalization 4.Re-epithelialization

  4. Pathophysiology of Wound Healing • cytokines growth factor blood extracellular matrix

  5. Composition of Honey Carbohydrate Protein, Enzyme, Amino acid Vitamins, Minerals, Heavy metals Aroma compounds Polyphenoliccompounds

  6. Mechanism of Action Physical properties hygroscopicity hypertonicity lower pH Osmolarity

  7. Hydrogen peroxide (H2O2) 1.Proliferation of fibroblast & angiogenesis 2. VEGF form Macrophage 4.Inhibit Bacterial growth 5.DNA strand break (Bacteria) 3.Leukocyte recruitment

  8. Non-peroxide and Antioxidants 1.Catalase 2.Gluconic acid 3.Carotenoids 4.Vitamin C and Vitamin E 5.Polyphenolic compounds

  9. Non-peroxide and Antioxidants 1.Catalase 2H2O2 Catalase 2H2O + O2

  10. Non-peroxide and Antioxidants 2. Gluconic acid

  11. 3.Carotenoids 4.Vitamin C & Vitamin E Non-peroxide and Antioxidants

  12. Polyphenoliccompounds Example • Caffeic acid • Cresol • Thymol • Quercetin • Galangin • Luteolin

  13. Polyphenoliccompounds • Antibacterial activity • Antioxidant properties • Inflammation

  14. Lymphocyte & Phagocyte functions IL-1↑ • T-cell activation • B-cell maturation - CSF stimulation MM6 + Honey • TNF-α ↑ • - Tumor cell • T-cell & B-cell • proliferation • Cytotoxic T-cell • - Immunoglobulin • - Macrophage • & Neutrophil • - Angiogenesis • - Fibroblast • - IL-6 IL-6 ↑ - B-cell maturation - Antibody production - Keratinocyte activation

  15. Acid Properties Protease ↓ Oxygen pH↓ Wound healing Micro-organism Fibroblast

  16. Nitric oxide (NO) • Cellular death

  17. Nitric oxide (NO) • Vasodilation Smooth muscle cell GTP NO NO GC Ca2+ cGMP Vasodilation

  18. Nitric oxide (NO) • Angiogenesis NO  VEGF  angiogenesis • Increase vascular permeability

  19. Nitric oxide (NO) • wound contraction NO  cGMP  FGFs  fibroblast Strongly wound contraction  collagen

  20. Prostaglandins Arachidonic acid Honey COX Prostaglandins Inflammation • Prostaglandins inhibit antibody synthesis & • stimulated regulatory T-cell • Honey inhibit COX • Decrease Prostaglandins in plasma

  21. Case Report

  22. Day 0

  23. Day 1-3

  24. Day 7

  25. Summary Catalase H2O2 Gluconic acid High osmolarity NO Polyphenolic compounds Prostaglandins Lymphocyte & Phagocyte functions Carotenoid Vitamin C & E

  26. …for your attention

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