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Percent of Patients Achieving Target Level at 30 Days

Achieved Levels of On-Treatment Reactivity (30 Days): Stratified by Randomization Treatment Arm. Insufficient pharmacodynamic response may have contributed to the lack of observed clinical effect in the GRAVITAS trial. 100. Standard Dose High Dose. 80. 60.1. 60.

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Percent of Patients Achieving Target Level at 30 Days

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  1. Achieved Levels of On-Treatment Reactivity (30 Days): Stratified by Randomization Treatment Arm Insufficient pharmacodynamic response may have contributed to the lack of observed clinical effect in the GRAVITAS trial. 100 Standard DoseHigh Dose 80 60.1 60 Percent of Patients Achieving Target Level at 30 Days 48.4 37.9 40 25.8 40 0 < 208 PRU < 230 PRU HD group, CV events according to P2Y12 reaction units (PRU) < 208:HR 0.48 (95% CI, 0.18-1.25), p = 0.15 Price MJ, Angiolillo DJ, Teirstein PS et al. Circulation. 2011;124:1132-7.

  2. On-Treatment Reactivity as a Time-Varying Covariate: Unadjusted Hazard of CV Death, MI, and ST HR (95% CI) p-value 60 Days < 230 PRU 0.62 (0.25-1.51) 0.30 < 208 PRU 0.18 (0.04-0.79) 0.20 0.01 0.1 1 10 Hazard Ratio 6 Months HR (95% CI) p-value < 230 PRU 0.71 (0.41-1.23) 0.20 < 208 PRU 0.43 (0.23-0.83) 0.01 0. 1 1 10 Hazard Ratio PRU: P2Y12 reaction units Price MJ, Angiolillo DJ, Teirstein PS et al. Circulation. 2011;124:1132-7.

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