V i s i M i x Simulation of Mixing Processes

1. VisiMix Simulation of Mixing Processes VisiMix Ltd, PO Box 45170, Jerusalem, 91450, Israel Tel: 972 - 2 - 5870123 Fax: 972 - 2 - 5870206 E-mail: info@visimix.com

2. VisiMix Simulation of Mixing Processes Presentation Contents: - The Customers - The Technology - ROI - VisiMix Products - Saving Examples

3. About Us VisiMixis a unique software enabling chemical engineers, process engineers and R&D personnel to visualize mixing processes via a simple, user friendly interface. Our products allow significant savings in time and costs by drastically reducing the need for trial-and-error. They have been successfully adopted by hundreds of companies.

4. Customers and Markets Our Customers

5. What Our Customers Say About Us From the Dow Chemicals Intranet Website “VisiMix: This is a highly accessible PC software for mixing calculations available from VisiMix Ltd., an Israeli company. It is a rating calculation tool for both non-reactive and reactive mixing involving blending, solid suspension, gas dispersion, liquid-liquid dispersion, or heat transfer processes in stirred vessels. It calculates the important process parameters for single- and two-phase systems – power consumption, circulation rates, local concentrations of solutes and suspended particles, drop size, concentrations of reactants, etc … ” Dr. Victor Atiemo-Obeng Dow Chemicals Co.

6. What Our Customers Say About Us “I am very pleased in applying your software.” L'Oreal, France “We have been using VisiMix. We have found it an accurate tool ... Based on our success with the product, our Japanese colleagues at Fuji Xerox have bought a copy for their work.” Emily Moore,Xerox Research Center of Canada

7. Customers and Markets Customer List 1. L'Oreal, France 2. BASF AG, Germany 3. Dow Chemical Company, USA 4. Searle (MONSANTO), USA 5. Lightnin, USA 6. LG Chemicals, S. Korea 7. Xerox , Canada & USA 8. The Gillette Co., USA & UK 9. De Dietrich, France & USA 10. ENIChem, Italy 11. Eli Lilly & Company, USA 12. NIPPON, Japan 13. Novartis, USA 14. Millennium, USA 15. ICI, UK 16. Hercules, USA 17. Pfizer, USA&UK&Gr. 18. Mitsubishi Chemicals 19. Abbott Laboratories, USA 20. GlaxoWellcome,UK&Singapore 1. L'Oreal, France 2. Techmix S.r.o, Czesh Republic 3. BASF AG, Germany 4. BASF, Denmark 5. BP Chemicals - Wingles, France 6. Sanofi Recherche, France 7. Technimont, Italy 8. Nycomed Imaging, Norway 9. Hoesch & Sohne, Germany 10. DSM, The Netherlands 11. Searle (MONSANTO), USA 12. Lightnin, USA 13. Chevron, USA 14. Teva, Israel 15. Plantex, Israel 16. Bromine Compounds, Israel 17. ENSIC, France 18. LG Chemicals, Taejon-city, S. Korea 19. LG Tech, Yeochon-city, S. Korea 20. Lonza, Switzerland 21. Thai Plastic and Chemical Public Company, Thailand 22. Xerox Research Centre of Canada, Canada 23. Xerox, USA 24. The Gillette Co., USA 25. Gillette, UK 26. Lecaros, Chile 27. SK Chemicals, S. Korea 28. Dow Chemical Company, USA 29. Monsanto, USA 30. Buchi AG, Switzerland 31. Agisys, Hungary 32. Samsung, S. Korea 33. Mervers, Holland 34. American Cyanamid Company, USA 35. Belinka Belles, d.o.o., Slovenia 36. LG Chem. , ABS Division (S. Korea) 37. BFGoodrich Advanced Technology Group, US 38. PT MECO INOXPRIMA, Indonesia 39. Ion Exchange, India 40. IL JIN Eng. & Const. Ltd., Korea 41. CSIR Ltd., South Africa 42. PTI, Brazil 43. De Dietrich, France 44. De Dietrich, USA 45. Rhodia (Rhone Poulenc Group), Brazil 46. Inymassa, Spain 47. ENIChem, Italy 48. Satake, Japan 49. Chesebrough-Pond’s, USA 50. Unilever, Italy 51. Schering-Plough, USA 52. Ontec, Israel 53. Cytec, USA 54. Degussa, Germany 55. IHN Groningen BV, the Netherlands 56. PEAS BV, the Netherlands 57. Eli Lilly & Company, USA 58. BSL (Dow group), Germany 59. VMD PTE Ltd., Singapore 60. Tecnicas Reunidas, Spain 61. NIPPON, Japan 62. Chr. Hansen, Denmark 63. Danisco, Denmark 64. Novartis, USA 65. SNECMA, France 66. Millennium, USA 67. Ucosan B.V., Holland 68. Norde Veenendaal B.V., Holland 69. Akzo Nobel, Germany 70. Astra Charnwood, UK 71. ICI, UK 72. Stork, Netherlands 73. Hercules, USA 74. Luigi Menestrina, Italy 75. Siersma Leidshendam, the Netherlands 76. Sara Lee, the Netherlands 77. Pfizer, USA 78. Pfizer, UK 79. Pfizer, Germany 80. Beiersdorf AG, Germany 81. Sintef Applied Chemistry, Norway 82. Chemitec OY, Finland 83. Makhteshim, Israel 84. Chemagis, Israel 85. Nitto Denco, Japan 86. 3M, USA 87. Broom Chemie, the Netherlands 88. Atlas-Stord, Denmark 89. Canon, Japan 90. Mitsubishi Chemicals 91. Imation, USA 92. NIKKI, Japan 93. Fuji Xerox, Japan 94. Oxy Vynils 95. Scanlube, Sweden 96. GlaxoWellcome, Singapore 97. GlaxoSmithKline, UK 98. SmithKline Beecham, USA 99. M&F Process Simulation, The Netherlands 100. Abbott Laboratories, USA 101. Air Products, USA 102. Gruppo Lepetit, Italy 103. Johnson Polymer, Holland 104. Dow Corning, USA 105. Pharmacia Biotech, Sweden 106. Panandiker Research & Development (P) Ltd., India 107. Fujifilm, Japan 108. Katholieke Hogeschool Brugge-Oostende, Belgium 109. The Casali Institute, Israel 110. Noordelijke Hogeschool Leeuwarden, the Netherlands 111. Stettin University 112. Taiwan University 113. Ecole d'Electrochemie, France 114. Ecole Polytechnique, Canada 115. University of Western Ontario, Canada 116. University of Barcelona, Spain 117. Taejon National University, S. Korea 118. Otto von Guericke Universitat, Germany 119. Tsinghua University, China 120. VUOS, Czesh Republic 121. Universita di Roma, Italy 122. Hanyang University, S. Korea 123. Royal Institute of Technology, Sweden Total : 123 customers

8. De Dietrich - Example http://www.ddpsinc.com/MixingSimulations.htm

9. De Dietrich - Example http://www.ddpsinc.com/Visimix.htm

10. Simple and Effective Technology - Simulation of Mixing Processes The First and the only tool in the Industry Reliable and accurate results Based on More Than 300 Man Years of R&D and Industry Experience Replacing Pilot Experiments Accelerated Time-to-Market process User Friendly and easily accessible

11. Simple and Effective Benefits (The ICI Example) Product Cost Return On Investment (ROI) Per Year basis Savings Per project - $20,000 Per year - $150,000 (5-10 projects per year) $15,000 $15,000 $15,000 $15,000 $15,000 Quality Time Time To Market

12. VisiMix Products Introduction • VisiMix software: • Based on advanced scientific knowledge and practical expertise • User-friendly and easy to operate • Requires easily accessible initial data • The latest VisiMix products are: • VisiMix 2K8 Turbulent • VisiMix 2K8 Laminar • VisiMix 2K8 Different Impellers • VisiXcel- Data Base • Pipe Line

13. VisiMix Products VisiMix Software Products • VisiMix 2K8 Turbulent – for low-viscosity liquids and multiphase systems. • The program provides process parameters necessary for analysis, scaling-up and optimization of mixing tanks and reactors with all types of impellers • Calculations of: • Blending • Suspension • Dissolution • Emulsification • Gas dispersion • Heat transfer • Chemical reactions • Mechanical stability of shafts

14. VisiMix Products VisiMix Software Products • VisiMix 2K8 Laminar - for highly viscous media • Newtonian and non-Newtonian • Macro-scale blending • Micromixing in high-shear areas • Heat transfer •    pastes•    creams•    shampoos•    liquid soaps•    gels•    ointments•    paints:•    coatings•    slurries•    polymer solutions

15. VisiMix Products VisiMix Software Products • VisiMix 2K8 Different Impellers – for combined mixing devices The program handles mixing devices consisting of any 2 – 5 impellers. Different distances between impellers Used in combination with VisiMix Turbulent. Provides parameters of hydrodynamics, turbulence and heat transfer.

16. VisiMix Products VisiMix Software Products • VisiMix VisiXcel – Data Base (DB) – automatic conversion tool: Visimix Output to Excel Spreadsheet • Integrates VisiMix report parameters in standard Excel worksheets • Analysis VisiMix results in Excel • Builds a Database of mixing tanks and reactors. • Builds a Database of projects - for processes • Makes correlation between plant equipment nomenclature to VisiMix database of mixing tanks and reactors in VisiMix Project Database. • Easy access to design data of the mixing tanks, to process parameters and to corresponding results of VisiMix modelling. • Results of VisiMix mathematical modelling in the VisiMix VisiXcel-DB and arrange the data according to the reactor nomenclature. • Easy access to recalculation of the VisiMix modelling from the Database of the reactors & the projects

17. VisiMix Products VisiMix Software Products • VisiMix Pipe-Line • Calculates hydraulic resistance of simple pipelines for liquid viscosity and non-Newtonian products. • Chemical engineers benefit from a quick and user friendly method for charging times and the bottle-necks in the line. • Includes : - Pipes - Riffled hoses – Elbows – Valves - And more • Also comes with a database containing rheological constants for the typical commercial non-Newtonian products - pastes, creams, shampoos, paints, etc. (see Help Section for details) • The first and only tool calculating flow resistance for liquids that correspond to Carreau rheological model. (See Help Section for details)

18. VisiMix Orientation VisiMix Demonstration Tools The VisiMix Demonstration Tools: • VisiMix Turbulent – Examples & User Guide • VisiMix Laminar - Examples & User Guide • VisiMix Different Impellers – Examples & User Guide • VisiMix Turbulent SV – Trial & Education • VisiMix Review of Mathematical Models • Selected Verification Examples The Comparison between Published Experimental Data and VisiMix Calculations

19. Saving Examples Finance Saving Examples (ROI) • Cooling A Paste • Paints • Suspension in a Batch Reactor • Scale up Methodology

20. Finance Saving Examples (ROI)

21. Cooling a Paste

22. Cooling a Paste

23. Cooling a Paste

24. Cooling a Paste

25. Cooling a Paste

26. PAINTS

27. PAINTS

28. PAINTS

29. PAINTS

30. PAINTS

31. PAINTS

32. Suspension in a batch reactor

33. Suspension in a batch reactor

34. Suspension in a batch reactor

35. Suspension in a batch reactor

36. Suspension in a batch reactor

37. Non ideal stirring – non homogeneity • VisiMix software is used in order to find the required stirring characteristics. For example: The product XXXX is produced at a solid liquid reaction. The main reaction at this process is: BBCM + TA + POCA →XXXX POCA reagent properties: • Solid • High particle size: mean=735mm • High density: 2300 kg/m3 VisiMix was used for suspension calculation.

38. Scale up optimization using simulation experiments. Scale Up Methodology (J.M. Berty. CEP, 1979)

39. Scale up optimization using simulation experiments. Scale Up Methodology (J.M. Berty. CEP, 1979)

40. Scale Up optimization using simulation experiments.

41. Scale Up optimization using simulation experiments. Financial aspects # produced lots needed until till a stable process is achieved

42. Summary • Save per project • Save during development

43. Thank You • Positive reaction from customers from all over the world confirms: • - VisiMix is of tremendous help wherever mixing is involved. • Thank you • From the VisiMix Team

44. Thank you for your attention