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Mirjana Babić, mag.biol.mol. Laboratory for Developmental Neuropathology

Annual m eeting of the COST ACTION CM1103 Neuropathology and neuropharmacology of monoaminergic system Bordeaux , 8 -1 0 Oc t 2014. Pathogenesis and early diagnosis of Alzheimer’s disease: involvement of the monoaminergic system. Mirjana Babić, mag.biol.mol.

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Mirjana Babić, mag.biol.mol. Laboratory for Developmental Neuropathology

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  1. Annual meeting of theCOST ACTION CM1103 Neuropathology and neuropharmacology of monoaminergic systemBordeaux, 8-10Oct 2014 Pathogenesis and early diagnosis of Alzheimer’s disease: involvement of the monoaminergic system Mirjana Babić, mag.biol.mol. Laboratory for DevelopmentalNeuropathology Croatian Institute for BrainResearch

  2. 1. Involvement of the monoaminergic system in pathogenesis of Alzheimer’s disease Does Aβ pathology precedes tau pathology? Andreasson et al., 2007.

  3. How are monoaminergic nuclei involved in this process?

  4. 1) Šimić et al., 2014.

  5. 2) Theearlyoccurrenceofbehavioral, andpsychologicalsymptomsofdementiasuggestsbrainsteminvolvement, and more specificallyoftheserotonergicnuclei. Šimić et al., 2009. 3) Plaque formation in the brain of transgenic mouse model (APPswe/PS1DE9 ) of AD causes the deterioration of sleep–wake cycle lesions of the raphe nuclei cause insomnia Roh et al., 2012.

  6. 4) exposure to inorganic mercury, bismuth and silvercan lead to AD-like pathology in noradrenergic locus coeruleus  neurons spreads to neighbouring serotonergic dorsal raphe neurons locus coeruleusneurons

  7. 2. Monoamine metabolites in early diagnosis of Alzheimer’s disease • Controversialresults of the studies on CSF monoamine metabolites in AD patients

  8. Core CSF biomarkers Aβ1-42 T-tau P-tau181 NovelCSF biomarkers P-tau231 VILIP-1 P-tau199

  9. Noninvasivelymeasuredpotential AD biomarkers Laczo et al., 2009. Measurement od event-related potentials.

  10. Components of event-related potentials (reaction times and P300 amplitude) differentiated two groups of MCI patients with pathological and normal levels of p-tau199 and VILIP-1.

  11. http://alzbiotrack.hiim.hr/ Croatian Science Foundation

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