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Mutations. Gene Mutations. Mutations that result in changes to a single gene. Point Mutation. One base pair in the DNA sequence is copied incorrectly. Sickle Cell Anemia. Normal vs. Sickle Cell. Normal DNA: {TAG}{CTT}{ATT} RNA: {AUC}{GAA}{UAA} Sickle Cell
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Gene Mutations • Mutations that result in changes to a single gene.
Point Mutation • One base pair in the DNA sequence is copied incorrectly.
Normal vs. Sickle Cell • Normal DNA: {TAG}{CTT}{ATT} RNA: {AUC}{GAA}{UAA} • Sickle Cell DNA: {TAG}{CAT}{ATT} RNA: {AUC}{GUA}{UAA}
Frameshift Mutation • A base pair is either deleted or inserted in the DNA code shifting all of the base pairs after it.
Cystic Fibrosis • Normal DNA: TAG]TAA]AAA]CCT]CAC] RNA: AUC]AUU]UUU]GGA]GUG • Cystic Fibrosis DNA: TAG]TAA]CCT]CAC RNA: AUC]AUU]GGA]GUG
Chromosomal Mutation Mutations that take place that impact entire chromosomes!
