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Patent Ductus Arteriosus Occlusion Device

Patent Ductus Arteriosus Occlusion Device. Christina Mathieson Trung Nguyen Advisor: Dr. Tom Doyle BME 273 – Senior Design Project. Patent Ductus Arteriosus: General Information. Connection of aorta and pulmonary artery Functionally beneficial prior to birth

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Patent Ductus Arteriosus Occlusion Device

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  1. Patent Ductus Arteriosus Occlusion Device Christina Mathieson Trung Nguyen Advisor: Dr. Tom Doyle BME 273 – Senior Design Project

  2. Patent Ductus Arteriosus:General Information • Connection of aorta and pulmonary artery • Functionally beneficial prior to birth • Maintained by low oxygen and high prostaglandins • Usually closes within 10-18 hours of birth • Abnormal if patent after 3 months • 1 in 2500 • Female:male 2:1

  3. Patent Ductus Arteriosus:Causes • All factors unknown • Prematurity of infant • Rubella infection • Random

  4. Patent Ductus Arteriosus:Effects • Increased volume load on left atrium and ventricle • Distention and dilation • Delay in postnatal pulmonary vascular changes • Growth retardation, breathlessness, poor feeding • Congestive heart failure • Bacterial endocarditis, aneurysm of ductus

  5. Patent Ductus Arteriosus:Shapes Type A: Cone Type B: Window Type C: Tube Type D: Aneurismal Type D: Irregular Cone

  6. Current Treatments: Surgery • Left posterolateral thoracotomy • Ligation or dissection • Chest tube 24hrs • Hospital 6-7 days • 6-8 month recovery

  7. Current Treatments: Coils • Most common method • Use multiple coils • Materials: • Surgical grade stainless steel • Dacron fibers • Problem: • Cannot occlude smaller PDAs • Easily dislodge when too many coils

  8. Current Treatments: Rashkind • Double Umbrella • Polyurethane fabric on stainless steel frame • Wire frame limits sizes • Must pre-order based on approx. size of PDA

  9. Our Goals • PDA occlusion device • Delivered via 6 – 7F catheter • Effective for all ages • Conforms to various shapes of PDA • Able to retract and reposition • Biocompatible material (foam) • Low cost

  10. Project Timeline Currently, have basic design idea. Goal for this month: develop testing prototype, determine material, create delivery system

  11. Work Completed • Research • PDA background: current treatments, material ideas, catheter sizes • Device shapes: Rashkind, coils, etc. • Determined Shape: Mushroom • Ideas: • Delivery system • Materials

  12. Mushroom Shape • Flat top in Aorta • Conical / Tubular base in PDA • Top prevents dislodging • Base provides surface for coagulation

  13. Delivery System • 6-7 F catheter • Similar to Rashkind implantation procedure • Enter PDA via Pulmonary Artery

  14. Future Work • Modify mushroom shape to prevent puckering • Improve delivery system idea • Finalize material selection • Build prototype • Look into methods of testing device

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