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Brucellosis under supervision of Prof./ Sherein Saeid Abdelgayed

Brucellosis under supervision of Prof./ Sherein Saeid Abdelgayed. Brucellosis.

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Brucellosis under supervision of Prof./ Sherein Saeid Abdelgayed

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  1. Brucellosisunder supervision of Prof./ShereinSaeidAbdelgayed

  2. Brucellosis Brucellosis, a bacterial disease caused by members of the genus Brucella, remains one of the most common zoonotic diseases worldwide, also cause abortion which is common and rate varies from 30%-80%. So this disease is very dangerous as it can affect man and also cause large economic losses by decreasing milk yield and aborted fetus.

  3. Brucellosis

  4. Synonyms

  5. Points of interest • Define • Causative agent • Route of infection • Pathogenesis • Microscopic examination • Macroscopic examination

  6. Mind Mapping of Brucellosis keyword Brucella intracellular chronic Reticuloendotheil cells • Persistfor long time or lifelong. • M.O live inside macrophages. • localization of the M.O in any organ causes granuloma formation. • [spleen-Lymph nodes-liver] Genital system • Female ;mammary gland, it’s L.N, pregnant uterus. • Male; testis, accessory glands [S.Vesicle,Epididymis & prostate]

  7. Brucellosis Define It is a chronic bacterial infection affect domestic animals and man. it is characterized by abortion. Cause Brucella species, which is gram –ve bacilli and intracellular. B.melitensisB.abortusB.suisB.ovis Goat cattle pig sheep

  8. Route of infection • Ingestion of raw milk • Through conjunctiva • Intact or broken skin • By coitus

  9. 4 pathogenesis Regional L.N Brucella Acute lymphadenitis L.N is enlarged, hyperplastic ,sinuses are filled w’ NQ and plasma cells. Th.duct Localization in organs blood bacteremia others Genital system Reticloendotheil cells Liver-spleen-L.N Synovial structures Female male Rich in erythritol M.O epitheloid cells Muliplicate • Help growth of M.O • Arthritis • Purulent tendovaginitis • N.B wherever the org.is localized, a granuloma develops? • LQ and plasma cells accumulated around these epithiloid cells .

  10. (continue) pathogenesis Localization in genital organs Female Fetus male Accessory gland Respiratory system Mammary gland Pregnant uterus Testis placenta (Seminal.vesc + prostate) Intracellular edema + necrosis Carancle cotyledon+chorionic villi Chronic mastitis Broncho- pneumonia Seminal- vesiclitis orchitis prostitis Retained placenta Abortion

  11. Abortion in cattle In severe cases In 7th &8th months of gestation(still birth abortion) In minor severity Premature birth The calf may be delivered normally and be viable or non viable

  12. PM lesions -Brucella abortus-infected aborted fetus with an acute diffuse severe fibrinous pleuritis -Edema in intercotyledonary placenta-increased opacity-leathery texture-light brown exudate-necrosis of cotyledon -Uterus from a Brucella abortus-infected cow immediately after abortion

  13. Macro: Retalined placenta due to:inflammatory enlargement of terminal portions of maternal villi

  14. Fibrinous bronchopneumonia with necrosis

  15. Bang’s disease

  16. Brucella spp.causes orchitis-Orchitis characterized by:-foci of necrosis in the testicular parenchymacoalesce to produce total testicular necrosisnecrotic parenchyma liquefies into pus surrounded by CT capsule

  17. Lesions in bull Chronic epididymitis in a ram due to Brucella ovis infection Although it appears that there is purulent exudate draining from the cut surface, the figure shows epididymal duct contents (mostly sperm) draining from a spermatic granuloma

  18. Asymmetrical epididymal tails from a ram due to Brucella ovis induced unilateral chronic epididymitis

  19. Complications: • Most common – Arthritis, spondylitis, epididymo-orchitis, chronic fatigue-Infertility • Neurological – 5% of cases • Other – Ocular, cardiovascular, additional organs and tissues

  20. Thanks for attention • Presented by:Sabah AliSalma Medhat

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