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Fidler, I.J., Nat. Rev. Cancer (2003)

Road map to cancer metastasis. Fidler, I.J., Nat. Rev. Cancer (2003). Epithelial-to-mesenchymal transition: explaining cancer invasion and metastasis. Thierry, J.P., Nat. Rev. Cancer (2002). Classification of migration modes.

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Fidler, I.J., Nat. Rev. Cancer (2003)

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  1. Road map to cancer metastasis Fidler, I.J., Nat. Rev. Cancer (2003)

  2. Epithelial-to-mesenchymal transition: explaining cancer invasion and metastasis Thierry, J.P., Nat. Rev. Cancer (2002)

  3. Classification of migration modes Wolf et al., Nat. Cell Biol. (2007); Friedl & Gilmour, Nat. Rev. Mol. Cell Biol. (2009); Friedl & Wolf, J. Cell Biol. (2010)

  4. The multiscale tuning model Friedl & Wolf, J. Cell Biol. 2010

  5. Collective cell migration Friedl & Gilmour, Nat. Rev. Mol. Cell Biol. (2009)

  6. siCtrl siMT1 F-actinCol2 ¾DAPIReflection MT1-MMP is required for collective invasion in 3D collagen lattices Wolf et al., Nat. Cell Biol. (2007)

  7. II Proteolysis of sheet-like interface Track widening (macrotrack) Collective cell invasion I Microtrack formation Macropatterning Collective invasion / invasive growth Individual and collective cancer cell invasion in 3D ECM V Release of microtrack IV Fibre realignment III Focalized proteolysis I / II Pseudopod elongation, adhesion, force generation Micropatterning * Single-cell migration * * * 10-15 µm F-actin ß1 integrin MT1-MMP Collagenolysis Proteolytic microtrack Moving fibres Sustained cleavage Zones of physical resistance Friedl & Wolf, Cancer Res. (2008)

  8. Variants of the dorsal skin-fold chamber model Drop-on Spheroid injection

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