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Deletion of the Allele CKR5 Restricts HIV-1 infection and AIDS Progression By Laurel Kovach

Deletion of the Allele CKR5 Restricts HIV-1 infection and AIDS Progression By Laurel Kovach. Dean, M., Carrington, M., Winkler, C., Huttley, G., Smith, M., Allikments, R., Goedert, J., Buchbinder, S., Vittinghoff, E., Gomperts, E., Donfield, S.,

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Deletion of the Allele CKR5 Restricts HIV-1 infection and AIDS Progression By Laurel Kovach

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  1. Deletion of the Allele CKR5 Restricts HIV-1 infection and AIDS ProgressionBy Laurel Kovach Dean, M., Carrington, M., Winkler, C., Huttley, G., Smith, M., Allikments, R., Goedert, J., Buchbinder, S., Vittinghoff, E., Gomperts, E., Donfield, S., Vlahov, D., Kaslow, R., Saah, A., Rinaldo, C., Detels, R. Science. 273 (1996)

  2. Individuals in the Population Respond Differently to HIV-1 Infection • Inherited traits play a role in the mortality from infectious agents. • Specific alleles of the human lymphocyte antigen locus are associated with different rates of AIDS progression. • MIP-1 alpha and MIP-1 beta are natural suppressors of HIV-1 infection.

  3. Chemokine Receptor CKR5 • Fusin is a co-receptor with CD4 for T-cell line tropic strains. • CKR5 is also known as CC-CKR5, CCR5, and with gene symbol CMKBR5. • Serves as the cellular receptor for RANTES, MIP-1 alpha, and MIP-1 beta. • CC chemokine receptors belong to the heterotrimeric G protein. • CC chemokine receptors consist of seven transmembrane domains and no introns.

  4. Testing was done on many different polymorphic loci to see if any genotypic variation occurred between HIV-1 infected and uninfected HIV-1 exposed.

  5. Behind the Chart • Sampling was done on both high risk HIV-1 exposed and unexposed individuals. • Genomic DNA was taken from 156 Caucasion participants and screened using 170 polymorphic loci. • Some of these were CD4, chemokine SCYA1, HLA-DQA1, TCRA, TCRB, and CKR5 • The graph displays allele and genotypic distortion.

  6. Looking at the Graph • The only variation between the HIV-1 exposed and unexposed participants was that by the CKR5 gene. • The CKR5 gene showed a significant amount of distortion.

  7. Frequency of the CKR5 Gene Between Homosexual Men and Hemophiliacs • Homosexual men that were AIDS negative showed much more of the CKR5 gene than those that were AIDS negative. • There was not much variation between AIDS positive and AIDS negative hemophiliacs.

  8. There is still much research necessary to determine what does and does not regulate HIV-1 infection and AIDS progression. But this puts us one step closer to a cure.

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