Sen S, Kawahara B, Chaudhuri G.

1. Breast Cancer and Antioxidants: The Mechanism of Cancer Progression GAUTAM CHAUDHURI Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA  Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA Sen S, Kawahara B, Chaudhuri G. Free Radic Biol Med. 2012 Oct 15;53(8):1541-51. doi: 10.1016/j.freeradbiomed.2012.06.030. Epub 2012 Jun 27. Sen S, Kawahara B, Chaudhuri G. Free Radic Biol Med. 2013 Apr;57:210-20. doi: 10.1016/j.freeradbiomed.2012.10.545. Epub 2012 Oct 23.

3. Production of Hydrogen Peroxide in Human Breast Cancer Cells: Comparison with Normal Human Breast Cells

4. Protein Expression /Specific Activity of Catalase in Human Breast Cancer Cells : Comparison with Normal Human Breast cells

5. Production of Superoxide and its Correlation to the Specific Activity of Catalase:

6. Silencing of Catalase Induces Growth of Human Breast Cancer Cells

7. Decrease in Protein phosphatase 2A ( PP2A) Activity upon Silencing of Catalase: Activity of PP2A is Dependent on the Redox State of its Thiols. MDA-MB-468

8. PP2A Activity was Inhibited by H2O2 but Induced by α-Tocopherol (A superoxide Quencher)

9. αTocopherol Catalase Superoxide H2O2 Reduced Growth PP2A

10. Inhibition of PP2A Activity Lead to Proliferation of Human Breast Cancer cells:

11. Overexpression of Catalase Lead to a Reduction in H2O2 Levels Accompanied by a Reduction in Cell Viability

12. Overexpression of Catalase Lead to Apoptosis in Human Breast Cancer cells

13. Overexpression of Catalase did not Induce Apoptosis in Normal Human Breast Cells

14. Human Breast Cancer Tissues Exhibited Higher Catalase expression but Lower Specific Activity when Compared to Normal Breast Tissues.

15. Antioxidants associated with decreased risks of Breast Cancer • J Natl Cancer Inst.1993 Sep 15;85(18):1483-92. • Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. The findings indicate that vitamin and mineral supplementation of the diet of Linxian adults, particularly with the combination of beta carotene, vitamin E, and selenium, may effect a reduction in cancer risk in this population. Ther Adv Med Oncol. 2014 Mar;6(2):52-68. Anti-inflammatory/antioxidant use in long-term maintenance cancer therapy: a new therapeutic approach to disease progression and recurrence. The high-activity catalase CC genotype was associated with an overall 17% reduction in risk of breast cancer compared with having at least one variant T allele (odds ratio = 0.83, 95% confidence interval: 0.69, 1.00). Vegetable and, particularly, fruit consumption contributed to the decreased risk associated with the catalase CC genotype.  Biochem Pharmacol. 2011 Nov 15;82(10):1384-90. doi: 10.1016/j.bcp.2011.06.007. Epub 2011 Jun 13. Catalase overexpression in mammary cancer cells leads to a less aggressive phenotype and an altered response to chemotherapy.

16. Endogenous Production Of Nitric Oxide Induces Growth in Human Breast Cancer Cells (ZR-75-30 & BT-474): ( Cross Talk with H2O2) ZR-75-30

17. Endogenous Production Of Nitric Oxide Induces Growth in Human Breast Cancer Cells (ZR-75-30 & BT-474): ( Cross Talk with H2O2)

18. Endogenous Production Of Nitric Oxide Does Not Induce Growth in Normal Human Breast Cells (ZR-75-30 & BT-474)

19. Nitric Oxide Synthase Activity Present in Mitochondrial Fractions from Cancer cells

20. Inhibition of Nitric Oxide Formation Lowers Superoxide as well as Hydrogen Peroxide Production

21. Summary Human Breast Cells Catalase