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Internal Dosimetry Software

ASSESSMENT OF OCCUPATIONAL EXPOSURE DUE TO INTAKES OF RADIONUCLIDES. Internal Dosimetry Software. Internal Dosimetry Software – Unit Objectives. This unit provides an overview of software that has been developed for internal dosimetry applications.

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Internal Dosimetry Software

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  1. ASSESSMENT OF OCCUPATIONAL EXPOSURE DUE TO INTAKES OF RADIONUCLIDES Internal Dosimetry Software

  2. Internal Dosimetry Software – Unit Objectives This unit provides an overview of software that has been developed for internal dosimetry applications. The unit addresses various kinds of software for internal dosimetry applications, and cites examples that illustrate the capabilities and limitations of different software types. At the completion of the unit, the student will understand the types of software available.

  3. Internal Dosimetry Software – Unit Outline • Introduction • Intake Fractions and Dose Coefficients • Dose Calculation Software

  4. Introduction

  5. Internal dosimetry software • Internal dosimetry related calculations are complicated • Biokinetic models • Dosimetric models • Direct measurement system calibrations • Several software packages have been developed to assist the dosimetrist

  6. Software is available for various tasks • Lookup tables • Dose coefficients • Retention fractions, etc. • Dosimetry calculations • Intake • Committed equivalent dose • Committed effective dose

  7. Dose Coefficients and Intake Fractions

  8. Rad_toolbox • Available, free of charge at http://ordose.ornl.gov/downloads.html • This toolbox provides ready access to data of interest in radiation protection of workers and members of the public. • Data include interaction coefficients for a, e- , photon and n radiations, nuclear decay data, biological and physiological data, etc. • Other supportive data include dose coefficients for intakes of radionuclides, for inhalation, ingestion for members of the public and workers. • The ORNL TM report is included in the download.

  9. Rad_toolbox Dose coefficient workers ex ICRP 68

  10. Rad_toolbox Contains dose coefficients for single organs (committed equivalent dose) and Committed effective dose . There is the possibility to transfer the values on an Excel file Dose coefficients for workers

  11. Rad_toolbox Dose coefficients for members of the population

  12. ICRP Database of Dose Coefficients • Contains dose coefficients from ICRP Publications 68 (Workers) and 72 (public), including organ doses • Inhalation of 10 different AMADs • 10 different integration periods • Text of ICRP 68 and 72 with search function • Biokinetic models for all elements • Results can be saved as ASCII files and printed

  13. ICRP Database of Dose Coefficients

  14. ICRP Database of Dose Coefficients

  15. ICRP Database of Dose Coefficients • Characteristics of output

  16. ICRP Database of Dose Coefficients • On line help tool: Biokinetic model

  17. C. Potter: Health Physics retention fraction CD • Pathway : Only Inhalation • Retention/ excretion curves in table form • CD-ROM attached to HP Nov. 2002 issue, Vol. 83 n. 5 • Intake retention fraction for stable element for respiratory tract, 24h urine, 24h feces, accumulated urine and accumulated feces (useful for 3 day collection of feces) . • Absorption Types F, M, S; 5 μm AMAD. • No dose coefficients !

  18. C. Potter: Health PhysicsIntake retention fraction

  19. C. Potter: Health Physics retention fraction CD HP Vol 83, 5 Nov. 2002 Biokinetic model parameters

  20. IAEA SRS 37 • Available, free of charge at www-pub.iaea.org/MTCD/publications/PDF/Pub1190/Pub1190_web.pdf • Tables : www-pub.iaea.org/MTCD/publications/PDF/Pub1190/tables.pdf • Characteristics • Pathway : Inhalation, ingestion, injection. • Absorption types , F, M, S, V. • AMAD = 1 and 5 μm. • Vapors • Tables in logarithmic intervals.

  21. IAEA SRS 37 • Standard worker • Sub-set of radionuclides present in ICRP 68

  22. IAEA SRS 37 • Retention / excretion function (also skeleton organ) • Dose coefficients for both inhalation, ingestion , injection.

  23. DCAL • Available, free of charge at http://ordose.ornl.gov/downloads.html • DCAL is a comprehensive software system for the calculation of tissue dose and subsequent health risk from intakes of radionuclides or exposure to radionuclides present in environmental media. • The system includes extensive libraries of biokinetic and dosimetric data and models representing the current state of the art. • DCAL maybe used either in an interactive mode or in a batch mode and is intended for experienced users with knowledge of computational dosimetry.

  24. DCAL

  25. DCAL Rate of equivalent dose in organs Activity in organs

  26. DCAL Committed organ doses and committed effective dose

  27. Dose Calculation Software

  28. Dose calculation software Software that can be used to estimate intake and internal doses has been developed using various techniques for different applications • Table look-up • Biokinetic and dosimetric modeling • Inhalation • Inhalation or ingestion • Single intake • Multiple intake

  29. MONDAL3 • Available free of charge, on request at http://www.nirs.go.jp:8080/anzendb/RPD/gpmd.php

  30. MONDAL3 • Calculates intake and committed effective doses a point at a time. • Several radionuclides • Selection between Inhalation and ingestion • Selection between workers and members of the population • Mode of intake , acute, chronic, uneven chronic. • m(t) values up to 1000 days after intake • Radioinuclide available 3H, 32P, 51Cr, 54Mn, 59Fe, 57Co, 58,60Co, 65Zn, 86Rb, 85Sr, 89,90Sr, 95Zr, 106Ru, 110mAg, 124Sb, 125Sb, 125,129,131I, 134,137Cs, 140Ba, 141,144Ce, 203Hg, 226,228Ra, 228,232Th, 234,235,238U, 237Np, 238,239,240Pu, 241Am, 242,244Cm and 252Cf. • Selection of AMAD = 0.1, 0.3, 1.0, 3.0, 5.0 e 10 µm for workers • = 1.0 µm for member of the population

  31. MONDAL3 Uneven chronic intake

  32. MONDAL3 Type of measurement m(t) value Evaluated intake I = M / m(t) t = time of measurement M = measurement value E(50) = e(50) * I

  33. Integrated Modules for Bioassay Analysis IMBA • Development began in 1997 by the NRPB • Features modular structure, interacting via ASCII data sets • Implements latest ICRP biokinetic models • Fitting uses maximum likelihood method • Use data recorded a being less than some minimum detection level • Specify multiple intake regimes

  34. IMBA • Each module developed independently by two separate organizations • Available in four different editions depending on included additional functions • Multiple intake regimes • Up to 30 associated nuclides • Simultaneous bioassay types

  35. IMBA Professional Plus • Present status: IMBA Professional Plus

  36. IMBA • Information available at www.hpa.org.uk/radiation/publications/software/imbapro_plus/index.htm

  37. IMBA • Information

  38. IMBA • Bioassay calculation

  39. IMBA • Use of multiple data-set for unique evaluation via maximum likelihood From Bioassay to intake From Intake to Bioassay

  40. IMBA • Dose Calculations

  41. AIDE • AIDE (Activity and Internal Dose Estimates) is a software for calculating activities in compartments and committed doses due to occupational exposures, and for performing intake and dose estimates using bioassay data • This software has been continuously developed and tested for more than twenty years. • Due to its extensive previous uses and challenges AIDE has proved to be suitable to all sorts of users, from beginners in internal dosimetry through its use in courses promoted by IAEA ARCAL (Harmonization of Internal Dosimetry Procedures (ARCAL LXXVIII),) up to advanced users performing evaluationsof dose reconstruction.

  42. AIDE • This software comprises three basic parts, which will be briefly described below: • Activity and Internal Dose Calculations, • Bioassay Interpretation, and • Edit Models.

  43. AIDE • Activity and internal dose calculations • It has the aim to calculate activities in compatments and committed doses due to occupational exposure for performing intake and dose estimates using bioassay data

  44. AIDE • Bioassay interpretation , intake evaluation chi squared test for fitting, possibility to de-select bioassay values.

  45. AIDE • The Model Editing form: Possibility to edit different model from default ICRP models

  46. AIDE • Detail of an original model: Source->Target fractions and biological half lives • A demonstration of AIDE will be performed next week.

  47. IDEA - System • Developed as spin-off project of the Research Center Karlsruhe. Expert system. Based on IDEAS Guidelines.

  48. Software Information Contacts • RAD_Toolbox http://ordose.ornl.gov/downloads.html • ICRP Database of Dose Coefficients http:// www.icrp.org • C. Potter. Intake retention fraction Health Physics Sellers of Health Physics

  49. Software Information Contacts • DCAL http://ordose.ornl.gov/downloads.html • MONDAL3 http://www.nirs.go.jp:8080/anzendb/RPD/gpmd.php • IMBA www.hpa.org.uk/radiation/publications/software/imbapro_plus/index.htm

  50. Software Information Contacts • IAEA SRS 37 http://www-pub.iaea.org/MTCD/publications/PDF/Pub1190/ Pub1190_web.pdf • DCAL http://ordose.ornl.gov/downloads.html • MONDAL3 http://www.nirs.go.jp:8080/anzendb/RPD/gpmd.php

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