생화학 (Biochemistry) 교재 : ? 참고교재 : 1. Biochemistry (4th edition) authored by Lubert Stryer

1. 생화학 (Biochemistry) 교재 : ? 참고교재 : 1. Biochemistry (4th edition) authored by Lubert Stryer 2. Biochemistry authored by Donald Voet 3. Biochemistry (3rd edition) authored by Zubay 4. Principles of Biochemistry authored by Lehninger Instructor : 김 정 기 (미생물학과) 전화번호 : 821-7559 E-mail : s_ks1kim@cnu.ac.kr

2. 강 의 계 획 서 I Introduction 1주 (4/2) Life. Water. II BIOMOLECULES. Nucleotides and Nucleic Acids. 1주~2주 (4/4, 4/9) Amino Acids. 2주 (4/9) Proteins: Structure and Function. 2주~3주 (4/11, 4/16) Carbohydrates. 3주 (4/16, 4/18) Lipids and biological Membranes. 4주 (4/23) III ENZYMES. Enzymatic Catalysis. 4주~5주 (4/25, 4/30) Enzyme Kinetics, Inhibition, and Regulation. 5주 (4/30) 중간고사5주 (5/2) IV METABOLISM. Introduction to Metabolism. 6주 (5/7) Glucose Catabolism. 6주 (5/9) Glycogen Metabolism and Gluconeogenesis. 7주 (5/14) Citric Acid Cycle. 7주 (5/14, 5/16) Electron Transport and Oxidative Phosphorylation. 8주 (5/21) Photosynthesis. 8주 ~9주 (5/23, 5/28) Lipid Metabolism. 9주 (5/30) Amino Acid Metabolism. 10주 (6/4) Mammalian Fuel Metabolism: Integration and Regulation.11주 (6/11) Nucleotide Metabolism 11주 (6/13) 기말고사12주 (6/18)

5. DNA 구조 발견 50 주년 (2003년) Watson, left, and Crick in 1953, showing off their famous model of DNA at the Cavendish Laboratory in Cambridge, England Rosalind Franklin DNA Double Helics DNA 분자는 두 가닥의 뉴클레오티드가 같은 축을 중심으로 나선상으로 꼬여 있다. DNA 분자의 바깥쪽에서 당과 인산이 골격을 이루고, 이 골격의 안쪽에 염기가 수소결합으로 연결되어 사다리와 같은 모양을 이루고 있다. A와 T 사이에 두개의 수소결합, G와 C 사이에 세개의 수소결합이 상보적으로 되어 있다. DNA 사슬의 폭은 2nm, 길이는 3.4nm 이며 나선의 한바퀴마다 열개의 염기쌍이 있다.

6. The Molecular Logic of Life The Chemical Unity of Diverse Living Organism 1. Chemical complexity and organization 2. Extract, transform, and use energy from environment 3. Capacity for precise self replication and assembly All Macromolecules Are Constructed from a Few Simple Comp. 1. Carbon, Nitrogen, Hydrogen, Oxygen 2. Amino Acids, Sugar, Nucleotides 3. Proteins, Carbohydrates, Nucleic Acids( DNA, RNA)

7. Energy Production and Consumption in Metabolism 1. Electron Flow 2. Free Energy 3. Exergonic and Endergonic Reaction 4. Adenosine triphosphate (ATP) 5. Enzymes ( Metabolism.... Anabolism, Catabolism) Biological Information Transfer 1. DNA molecules 2. Mutation

25. Cells Cells ; Structural and Functional Units of All Living Organisms. Two Major Classes : Prokaryotic Cell ..... No nuclear membrane Eukaryotic Cell .... Have nuclear membrane Prokaryotic Cell ( E. Coli ) 1. Cell Wall ( Cell Envelope), Cell Membrane 2. Nuclear Body( Nucleoid) ... circular DNA 3. Plasmid 4. Pilli, Flagella 5. Ribosome, Cytosol

26. Eukaryotic Cell ( Liver Cell) 1. Cell Membrane(Plasma Membrane) 2. Mitochondria 3. Nuclei, Nucleolus 4. Endoplasmic Reticulum ( Rough ER, Smooth ER) 5. Ribosomes 6. Nuclear Envelope ( Nuclear Pore) 7. Peroxisome, Lysosome 8. Cytoskeleton

40. Biomolecules of Biochemistry Chemical Composition and Bond: C, H, O, N, Functional Groups Configuration and Conformation: Stereoisomer, Chiral center, Optical isomer ect. Chemical Reactivity: Oxidation-Reduction Rx. Bond formation, Electron transfer, Group transfer, Biopolymer formation

41. Macromolecules and Monomeric Subunits: Protein, Nucleic acid, Lipid, Polysaccharides Cells have Structural Hierachy: Monomeric units, Macromolecules, Supramolecular complexes, Cells and Organelles