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Synaptic Action

Synaptic Action. Synaptic Potentials: EPSP IPSP. Synaptic Potentials. Excitatory Postsynaptic Potential (EPSP) triggered by excitatory neurotransmitters open ligand-gated Na + channels allows Na + to flow inside the cell causing a slight depolarization of the postsynaptic cell

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Synaptic Action

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  1. Synaptic Action • Synaptic Potentials: • EPSP • IPSP

  2. Synaptic Potentials • Excitatory Postsynaptic Potential (EPSP) • triggered by excitatory neurotransmitters • open ligand-gated Na+ channels • allows Na+ to flow inside the cell • causing a slight depolarization of the postsynaptic cell • moves the postsynaptic cell closer to firing an action potential • Inhibitory Postsynaptic Potential (IPSP) • triggered by inhibitory neurotransmitters • open ligand-gated K+ channels or Cl- channels • allows K+ to flow out of the cell or Cl- to flow inside the cell • causing a slight hyperpolarization of the postsynaptic cell • moves the postsynaptic cell further from firing an action potential

  3. The Battle to -55mV IPSP EPSP

  4. Neurotransmitters • Neuropeptides • Opioid peptides • Enkephalins (ENK) • Endorphins (END) • Peptide Hormones • Oxytocin (Oxy) • Substance P • Cholecystokinin (CCK) • Vasopressin (ADH) • Neuropeptide Y (NPY) • Hypothalamic Releasing Hormones • GnRH • TRH • CRH • Amines • Quaternary amines • Acetylcholine (ACh) • Monoamines • Catelcholamines • Epinephrine (EPI) • Norepinephrine (NE) • Dopamine (DA) • Indoleamines • Serotonin (5-HT) • Melatonin • Amino acids • Gamma-aminobutyric acid (GABA) • Glutamate (GLU) • Glycine • Histamine (HIST)

  5. Cholinergic (Ach) System * (PPT) * (BF)

  6. Noradrenergic (NE) System * (LC)

  7. Serotoninergic (5-HT) System * Raphe Nuclei

  8. Dopaminergic (DA) System 1Mesolimbic * Ventral Tegmental Area (VTA)

  9. Dopaminergic (DA) System 2Mesostriatal * Basal Ganglia

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