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Genetic Architecture of Complex Traits

Genetic Architecture of Complex Traits. Zhiwu Zhang. Complex traits. Controlled by multiple genes Influenced by environment Also known as quantitative traits Most traits are continuous, e.g. yield and height, Some are categorical, e.g. node number, score of disease resistance

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Genetic Architecture of Complex Traits

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  1. Genetic Architecture of Complex Traits Zhiwu Zhang

  2. Complex traits • Controlled by multiple genes • Influenced by environment • Also known as quantitative traits • Most traits are continuous, e.g. yield and height, • Some are categorical, e.g. node number, score of disease resistance • Some binary traits are still quantitative traits, e.g. diabetes • Economically important

  3. Dissecting phenotype • Y= G + E + GxE • G = Additive + Dominance + Epistasis

  4. Quantitative Trait Loci (QTL) • Specific regions in the genome that are associated with quantitative traits • The regions were traditionally considered as 10-15 cM. The regions evolved to 3-5 cM in fine mapping. • Suppose maize genome contains 50,000 genes and has genetic map =1700 cM • Each QTL we identify has roughly 100-150 genes • Gene cloning: identification the QTL regions at gene level • Ultimate goal: functional mutations

  5. Distribution of QTN effect • Normal • Geometry

  6. Theoretical geometric distribution • The probability distribution of the number X of Bernoulli trials needed to get one success • Prob (X=k)=(1-p)k-1 p

  7. Approximated geometric distribution • Effect(X=k)=pk

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