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PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine

PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine. Reporter: Fei Liu Supervisor: Prof. Zhi Yang 31 March 2014 Mentor: Nan Li and Hua Zhu. Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55. PET Imaging of Glutaminolysis in Tumors by 18F-(2S,4R)4-Fluoroglutamine.

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PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine

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  1. PET Imaging of Glutaminolysis in Tumors by 18F-(2S,4R)4-Fluoroglutamine Reporter: Fei Liu Supervisor: Prof. Zhi Yang 31 March 2014 Mentor: Nan Li and Hua Zhu Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

  2. PET Imaging of Glutaminolysis in Tumors by 18F-(2S,4R)4-Fluoroglutamine Reporter: Fei Liu Supervisor: Prof. Zhi Yang 31 March 2014 Mentor: Nan Li and Hua Zhu Contents:

  3. Contents: Contents: PET Imaging of Glutaminolysis in Tumors by 18F-(2S,4R)4-Fluoroglutamine Reporter: Fei Liu Supervisor: Prof. Zhi Yang 31 March 2014 Mentor: Nan Li and Hua Zhu Contents:

  4. 1 2 3 4 Contents: Background Research Summary Development

  5. 1 2 3 4 Contents: Background Research Summary Development

  6. 1 Background

  7. 1 2 3 4 Contents: Background Research Summary Development

  8. 2 Research Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

  9. 2 Research Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

  10. 2 Research Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

  11. 2 Research Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

  12. 2 Research Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

  13. 2 Research Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

  14. 2 Research Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.

  15. 1 2 3 4 Contents: Background Research Summary Development

  16. 3 In vitro tumor cell uptake of 18F-(2S,4R)4-Fluoroglutamine is higer than uptake of 18F-FDG. 1 Summary In vivo PET studies showed significant tumor uptake adnd trapping inside tumor tissue in 2 different tuor models. 2 The results support the feasibility of PET for the study of a fundamental change in tumor metabolism---high-rate glutaminolysis. 3

  17. 1 2 3 4 Contents: Background Research Summary Development

  18. 4 Development Kung HF，et al, Chemistry. Science, 2013 , 342(6157):429-30.

  19. 4 Development

  20. THANK YOU T

  21. Q&A

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