1 / 29

IMAGING OF CHEST INFECTIONS IN IMMUNOCOMPROMISED CHILD

IMAGING OF CHEST INFECTIONS IN IMMUNOCOMPROMISED CHILD. F.AKID, H.FOURATI, E.DAOUD, I.AMMAR, W. FEKI, L.SFAIHI*, M.HACHICHA*, Z.MNIF Radiology service, Hedi Chaker Hospital Sfax , Tunisia * Pedaitrics service, Hedi Chaker Hospital Sfax , Tunisia . PEDIATRICS : PD 14.

nani
Télécharger la présentation

IMAGING OF CHEST INFECTIONS IN IMMUNOCOMPROMISED CHILD

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. IMAGING OF CHEST INFECTIONS IN IMMUNOCOMPROMISED CHILD F.AKID, H.FOURATI, E.DAOUD, I.AMMAR, W. FEKI, L.SFAIHI*, M.HACHICHA*, Z.MNIF Radiology service, HediChaker Hospital Sfax, Tunisia *Pedaitrics service, HediChaker Hospital Sfax, Tunisia PEDIATRICS : PD 14

  2. Introduction: • The population of children afflicted with primary or secondary immunodeficiencies is in evolution • This complex and varied population is at high risk for pulmonary complications related to both their underlying disease state and to various treatment regimes • Our purpose is to describe the main imaging appearances of the common infectious complications in immunocompromised children and to emphasize on difficulties in the interpretation of chest imaging in these cases.

  3. Materials and methods: • Didactic poster, showing through a serie explored in our service different aspects of lung infections in children with various immunodeficient states • All patients underwent a chest radiograph and a chest CT scan.

  4. Results:

  5. Case 1: A 4-year-old boy with IL12 deficiency C D A B (A): Frontal chest radiograph demonstrates left upper lobe pneumonia (B, C and D): Axial images from an intravenous contrast-enhanced chest CT, soft-tissue algorithm, show large mediastinal abscesses (arrows), which were drained revealing Mycobacterium tuberculosis. This child also had multiple left lobe lung abscess (arrow head) and a sternal osteolysis.

  6. Case 2: (A): Frontal chestradiographdemonstratessubtle diffuse interstitialopacitiescaused by Pneumocystiscariniipneumonia. (B,C): Axial images, lung algorithm, from a CT examination through the chest demonstrates scattered bilateral ground glass and interstitial opacities. (D): Mosaic appearance with alternating of hyperdense and hypodense areas A 10-year-old boy with chronic granulomatous disease A B C D

  7. Case 3: (A,B and C) Axial images from a chest CT, lung algorithm, shows centrilobularmicronodules surrounded by a ground glass appearance mainly at the right lower lobe caused by a candidiasis. A 4-year-old boy with acute myeloid leukemia A B C

  8. Case 4: A 6-year-old boy with chronic granulomatous disease (A):Frontal Chest Radiograph shows hazy airspace consolidation in the left lung with air bronchogram. Enlargement of soft tissues and interruption of the left costal third anterior arc caused by an aspergillosis (B and C):Consolidation in the left upper lobe with chest wall invasion. A small consolidation in the middle lobe. A B C

  9. Case 4: A 6-year-old boy with chronic granulomatous disease (A and B):Control CT after 5 months: the pneumonia has not resolved. The chest wall invasion has occasioned parietal abscess (arrow) in front of the consolidation. A B

  10. Discussion: • The immunodeficiency states in children may be sub-divided into two major groups: • Congenital or primary immunodeficiencie • Acquired or secondary immunodeficiencie

  11. Discussion: Specific thoracic complications vary according to the child’s underlying immune status and specific treatment protocols. As such, the type of infection or other disease states encountered depends on : • The child’s type of immunologic abnormality • Severity of immunologic deficit • Therapeutic interventions • Environmental exposures

  12. Primaryimmunodeficiencies Humoral immunodeficiencies: • The most commonly encountered type of primary immunodeficiency, accounting for over 70% of all primary immunodeficiencies • Characterized by defectiveantibody production causingincreasedsusceptibility of affectedindividuals to recurrentpyogenic infections, particularlycaused by encapsulatedbacteria, such as Haemophilusinfluenzae, Streptococcuspneumoniae,andStaphylococci

  13. Primaryimmunodeficiencies Humoral immunodeficiencies: • Typical manifestations include recurrent pneumonia, otitis media, sinusitis, and sepsis • Radiographically, children classically demonstrate thoracic abnormalities related to recurrent pulmonary infections including bronchiectasis, bronchial wall thickening, and atelectasis • Bronchiectasis is commonly located in the middle and lower lobes with an upper lobe distribution being unusual

  14. Primaryimmunodeficiencies Cellular and combinedimmunodeficiencies: • Patients with cellular immunodeficiencies have increasedsusceptibility to disseminated viral and opportunistic infections. • Progressive pneumoniaoftenoccursbecause of respiratorysyncytial virus, parainfluenza 3 virus, Pneumocystiscarinii, varicella, or cytomegalovirus • Disorders include DiGeorge syndrome and severe combined immunodeficiency (SCID) • SCID syndrome is characterized by the absenceof both T- and B-cell function

  15. Primaryimmunodeficiencies Cellular and combinedimmunodeficiencies: • Chestradiographsmaydemonstratenarrowuppermediastinal contour and retrosternallucencycaused by absence of thymic tissue . • Pulmonary complications includerecurrentpneumonias cause by P carinii, parainfluenza, respiratorysyncytial virus, adenovirus, cytomegalovirus, or bacterialorganisms. • Pneumocystispneumoniatypicallymanifests as diffuse interstitialinfiltrates,whichmayprogress to alveolarinfiltrates

  16. Primaryimmunodeficiencies Partial combinedimmunodeficiency syndromes: • Partial combinedimmunodeficiency syndromes encompass a spectrum of disorderswithvariedclinical manifestations. • Thesediseasesinclude : • Wiskott-Aldrich syndrome, • Cartilage-hairhypoplasia, • Ataxia-telangiectasia, • Purine-nucleoside phosphorylase deficiency, • X-linkedlymphoproliferativedisease

  17. Primaryimmunodeficiencies Partial combinedimmunodeficiency syndromes: • Children with partial combined immunodeficiencies have increased susceptibility to recurrent sinopulmonary infections • Children afflicted with Wiskott-Aldrich syndrome and ataxia-telangiectasia have the highest malignancy rates of all primary Immunodeficiencies • Patients with ataxia-telangiectasia are highly susceptible to radiation-induced malignancies and use of ionizing radiation for evaluation of these children should beperformed judiciously

  18. Primaryimmunodeficiencies Disorders of phagocytic cells and adhesion molecules: • Chronic granulomatous disease is the most common phagocytic disorder, occurring in approximately 1 in 125,000 live births • this disorder is seen most commonly in males • These children develop recurrent infections, commonly with catalase-positive bacteria, such as Staphylococcus aureus or fungi including Aspergillus, caused by defective intra-cellular killing by neutrophils . • This disease usually presents before 1 year of age with pulmonary infections occurring most frequently

  19. Primaryimmunodeficiencies Disorders of phagocytic cells and adhesion molecules: • Chestradiographs or chest CT typicallydemonstratelymphadenopathy, recurrentpneumonia, and pleural thickening . • The radiographic manifestations of Aspergillus vary but segmental or lobarinfiltrates, nodularopacities, and cavitation are typical . • Recurrentpneumonias and pulmonaryabscesses are common • Otherthoracic manifestations includelymphadenitis, osteomyelitis, and chestwallabscesses

  20. Secondaryimmunodeficiencies: AIDS : • Most of these cases are acquired through vertical transmission from HIV-positive mothers • Pulmonary infections are a major source of morbidity and mortality in children with AIDS. • Fifty percent of children who die from AIDS do so as a result of complications from pulmonary disease • These children are at risk for many opportunistic infections, such as P carinii pneumonia (PCP) and mycobacterial pneumonia, acute bacterial pneumonias are common

  21. Secondaryimmunodeficiencies: AIDS : • The typical radiographic appearance of PCP includes increased interstitial markings, which spread from an initial perihilar distribution to the periphery. Alveolar opacities often accompany progression of interstitial disease • Adenopathy and pleural effusions are rarely seen in association with PCP • Chest CT in children with PCP typically demonstrates peribronchial cuffing, patchy consolidation, ground glass opacity and parenchymal cysts

  22. Secondaryimmunodeficiencies: AIDS : • Children with AIDS are also susceptible to mycobacterial infections, although the incidence is less common than in the adult population with AIDS. • The radiographic appearance mimics that seen in immunocompetent children with hilaradenopathy and lobar collapse or consolidation • Miliary tuberculosis in children with AIDS, however, is distinctly unusual

  23. Secondaryimmunodeficiencies: Bone marrow and stem cell transplantation : • The temporal sequence of events after BMT is predictable with initial profound neutropenia lasting from 2 to 4 weeks • Local lung defense mechanisms are also impaired after BMT for up to 12 months • Early infectious complications after BMT are most frequently caused by bacteria and fungi, most commonly gram-negative organisms and Aspergillus • Chest radiographs may show a classic focal or lobar consolidation, although atypical features are not uncommon

  24. Secondaryimmunodeficiencies: Bone marrow and stem cell transplantation : • Children are also at increased risk of viral infections, most importantly respiratory syncytial virus, herpes simplex virus, adenovirus, and varicella • Radiographic findings are nonspecific but may include marked pulmonary hyperinflation and bilateral perihilar opacities, which coalesce into diffuse airspace disease • Fungal pneumonias in children who have undergone BMT are typically caused by Aspergillus or Candida species.

  25. Secondaryimmunodeficiencies: Bone marrow and stem cell transplantation : • Angioinvasive pulmonary aspergillosis is reported to occur in approximately 4% of children after BMT • Late sequellae of BMT differ from the complications encountered early in the posttransplant period and include infections and bronchiolitisobliterans, diffuse alveolar damage, lymphocytic interstitial pneumonitis, and relapse of the underlying disease

  26. Secondaryimmunodeficiencies: Solid organ transplantation: • The thorax is a common site of infectious complications to the pediatric transplant recipient after solid organ transplantation • Long-term immunosuppressive therapy increases the risk of infection and the risk of neoplasms including various lymphoproliferative disorders • Children who have undergone renal transplantation are highly susceptible to infection with cytomegalovirus • P carinii pneumonia (PCP) and Aspergillus infection are also common infections after renal transplantation

  27. Secondaryimmunodeficiencies: Patients with cancer: • Children undergoing chemotherapy and radiation therapy for malignancy are also at increased risk for pulmonary complications • Children who are predominately neutropenic as a result of chemotherapy are at risk for gram-negative infections, such as Pseudomonas aeruginosa and Klebsiella species, and gram-positive infections with such organisms as S aureus

  28. Secondaryimmunodeficiencies: Patients with cancer: • Children with leukemia are at increased risk for infection with S pneumoniae, H influenzae, and gram-negative bacilli • Children with T-cell defects related to high-dose corticosteroid treatment or Hodgkin’s disease are more likely to develop viral or fungal infections

  29. Conclusion: • Combination of clinical knowledge and radiological features is useful to understand the pathologic pulmonary changes encountered in the immunocompromised patients

More Related