'Sequence homology' diaporamas de présentation

Prediction of protein function

Prediction of protein function. Lars Juhl Jensen EMBL Heidelberg. Overview. Part 1 Homology-based transfer of annotation Function prediction from protein domains Part 2 Prediction of functional motifs from sequence Feature-based prediction of protein function Part 3

2.01k views • 146 slides

Lecture 2: Sequence Alignment BMI/IBGP 730

Lecture 2: Sequence Alignment BMI/IBGP 730. Kun Huang Department of Biomedical Informatics Ohio State University. Major issues in genomics Homology Format Search Alignment as an optimization problem Dynamical programming Hashing and BLAST Tools and examples. Charles Darwin

530 views • 41 slides

Biology 162: Computational Genetics Fall 2004

Biology 162: Computational Genetics Fall 2004. Todd Vision Assistant Professor Department of Biology, UNC Chapel Hill. Bioinformatics vs computational genetics. Bioinformatics : The application of computing technology to molecular biology

592 views • 39 slides

Lecture 2: Sequence Alignment BMI/IBGP 705

Lecture 2: Sequence Alignment BMI/IBGP 705. Kun Huang Department of Biomedical Informatics Ohio State University. Major issues in genomics Homology Alignment as an optimization problem Dynamical programming BLAST Tools and examples (in the lab session). Charles Darwin

470 views • 36 slides

Flow of information in a drug discovery pipeline

Flow of information in a drug discovery pipeline. Bioinformatics. Computational and Combinatorial Chemisty. Predictive ADME. Absorption Distribution Metabolism Elimination. Pharmacokinetic Bioavailability. Why is the prediction of ADME parameters so important ?.

1.11k views • 34 slides

BINF350, Tutorial 4 Karen Marshall

Blast in practice. BINF350, Tutorial 4 Karen Marshall. Aim. Examine how blast parameters (e.g. scoring scheme, word length) affect the alignment outcome To optimise blast parameters for alignments with different levels of sequence homology. v. Practical: Part 1.

303 views • 22 slides

Inheritance Patterns Related to Gender Determination

Inheritance Patterns Related to Gender Determination. Mechanisms of gender determination X-linkage Sex-limited and sex-influenced traits. A. Mechanisms of Gender Determination. Chromosomal mechanisms Gender determined by the presence or absence of certain chromosomes called sex chromosomes

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We are working in Tier I with mechanisms

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We are working in Tier I with mechanisms

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Genome analysis and annotation

Genome analysis and annotation. Which sequences code for proteins and structural RNAs ? What is the function of the predicted gene products ? Can we link genotype to phenotype ? (i.e. What genes are turned on when ? Why do two strains of the same pathogen vary in their pathogenicity ?)

164 views • 16 slides

IS A VIRUS A FACTOR IN AD?

1. Several persistent viruses can cause neurological disease. 2. HSV1 is implicated in AD because a) it has a propensity for latently infecting neuronal cells; b) it is ubiquitous; c) it affects, in acute infection, the brain regions which display the main pathological changes in AD.

262 views • 15 slides

Carbonic Anhydrase II

Carbonic Anhydrase II. Bayan K. Sheko University of Georgia Athens, Georgia December 2, 2010 . Background. Discovered in 1961 by Meldrum & Roughton Carbonic Anhydrase II is Lyase Catalyzes the reversible hydration of CO 2 H 2 O + CO 2 ?? H + + HCO 3 -

1.53k views • 10 slides

Aim: To understand how the olfactory transduction system is organized

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rPTPTD14

Classification of the vertebrate family of PTPs into Nontransmembrane (NT) and Receptor-like subtypes (R) based on PTP domain sequence homology. Subtypes. hPTPsigma ( PTPRS ). Inconsistent gene nomenclature is highlighted in red. mPTPsigma ( Ptprs ). PTPsigma. rPTPsigma ( Ptprd ).

92 views • 1 slides

C Wang et al. Nature 000 , 1-6 (2013) doi:10.1038/nature12167

Structural insight for the FZD receptors on the basis of their sequence homology with the SMO receptor. C Wang et al. Nature 000 , 1-6 (2013) doi:10.1038/nature12167.

83 views • 1 slides