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Biomedical images processing and analysis

Biomedical images processing and analysis. Biomedical images processing and analysis. Group members Massimo De Luca (2003-) Fellowship – PhD student Marco Foracchia (-2003) PhD student Alfredo Giani (2003-) Post doc Enrico Grisan PhD student – Post doc Lorenzo Marafatto (2005-) Fellowship

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Biomedical images processing and analysis

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  1. Biomedical images processing and analysis

  2. Biomedical images processing and analysis Group members Massimo De Luca(2003-) Fellowship – PhD student Marco Foracchia(-2003) PhD student Alfredo Giani (2003-)Post doc Enrico GrisanPhD student – Post doc Lorenzo Marafatto(2005-)Fellowship Alfredo RuggeriAssociate professor

  3. Biomedical images processing and analysis Cooperations J. Jaroszewski - Cornea Bank Berlin, Clinic of Ophthalmology, University School of Medicine, Berlin, Germany A. Neubauer - Dept. of Ophthalmology, Ludwig Maximilians University, Munich, Germany S. Piermarocchi – Dept. of Ophthalmology, University of Padova D. Ponzin - Veneto Eye Bank Foundation, Venice, Italy A. Pocobelli - Eye Bank, S. Giovanni-Addolorata Hospital, Rome, Italy P. Gain - Ophthalmology Department, Bellevue Hospital, Saint-Etienne, France A. Bezerianos - Dept. of Medical Physics, University of Patras, Greece G. Barbaro - Nidek Technologies, Padova, Italy P. Favaro - Siemens Corporate Research, Princeton (NJ), USA

  4. Biomedical images processing and analysis Publications

  5. Biomedical images processing and analysis Funding University of Padova: € 60.000 (shared) University of Padova: € 15.000 Ministry of University: € 20.000 Nidek Technologies: € 25.000 CARIPARO Bank Foundation: € 40.000

  6. Biomedical images processing and analysis 1. Cell contour recognition for in-vivo microscopy of corneal endothelium

  7. Cell contour recognition Statistical Correction ROI extraction Band-Pass Filtering ANN contour extraction Hole removal and Erosion Skeletonization Contour completion Perimeter extraction Correction

  8. Cell contour recognition Statistical Correction ROI extraction Band-Pass Filtering ANN contour extraction Hole removal and Erosion Skeletonization Contour completion Perimeter extraction Correction

  9. Cell contour recognition Statistical Correction ROI extraction Band-Pass Filtering ANN contour extraction Hole removal and Erosion Skeletonization Contour completion Perimeter extraction Correction

  10. Cell contour recognition Statistical Correction ROI extraction Band-Pass Filtering ANN contour extraction Hole removal and Erosion Skeletonization Contour completion Perimeter extraction Correction

  11. Cell contour recognition Statistical Correction ROI extraction Band-Pass Filtering ANN contour extraction Hole removal and Erosion Skeletonization Contour completion Perimeter extraction Correction

  12. Cell contour recognition Statistical Correction ROI extraction Band-Pass Filtering ANN contour extraction Hole removal and Erosion Skeletonization Contour completion Perimeter extraction Correction

  13. Cell contour recognition Statistical Correction ROI extraction Band-Pass Filtering ANN contour extraction Hole removal and Erosion Skeletonization Contour completion Perimeter extraction Correction

  14. Cell contour recognition Statistical Correction ROI extraction Band-Pass Filtering ANN contour extraction Hole removal and Erosion Skeletonization Contour completion Perimeter extraction Correction

  15. Cell contour recognition Statistical Correction ROI extraction Band-Pass Filtering ANN contour extraction Hole removal and Erosion Skeletonization Contour completion Perimeter extraction Correction

  16. Nidek Technologies NAVIS-ENDO system • The ENDOsoftware is a module of the system for ophthalmology.

  17. A glimpse of tomorrow …

  18. Biomedical images processing and analysis 2. Fourier analysis for the estimation of cell density on eye bank images of donor corneas

  19. 2250 cell/mm2 Fully automatic density estimation • AIM: • to develop a fully automatic technique for cell density estimation (no user intervention). • It must be without cell contour detection.

  20. Frequency-based density estimation • A repetitive pattern of cell borders is clearly visible. • Spatial frequency of this pattern is proportional to cell density. • Frequency information is available through Fourier analysis. • Information from Fourier analysis can provide an estimation of cell density.

  21. A circular band indicates that the endothelium image contains a repetitive pattern at a specific frequency. Spatial frequency is the radius of the band Frequency-based density estimation Gray-scale image of 2D-DFT log-magnitude. Radius of circular band can be used to estimate cell density.

  22. Position of second peak provides estimated frequency f of cell borders. Frequency-based density estimation

  23. Frequency-based density estimation (Ruggeri et al., Br J Ophthalmol, Mar 05)

  24. Nidek Technologies NAVIS-EyeBank system • The EyeBanksoftware is a module of the system for ophthalmology.

  25. Biomedical images processing and analysis 3. Tracking techniques for vessel-like structure • Applications to: • vessels in retina • nerves in cornea • Clinical outcomes: • length • tortuosity • bifurcations • caliber course • optic disc detection

  26. Tracking techniques in retina

  27. Tracking techniques in retina

  28. Tracking techniques in cornea

  29. Biomedical images processing and analysis 4. Methodologies in eye fundus analysis for the diagnosis of retinopathy Diabetic retinopathy characterized by fundus lesions • Automatic and objective tools: • wide screening • disease assessment & monitoring in time • (new) drugs efficacy

  30. Eye fundus analysis • Three steps: • Detection • Classification & measurement • Clinical assessment

  31. Biomedical images processing and analysis 5. Design and realization of an adaptive optics fundus camera Eye RetinalImaging Flashpath Wavefrontsensor Image Processing

  32. Biomedical images processing and analysis 5. Design and realization of an adaptive optics fundus camera Imagecorrected Imageacquisition Defocus Coma Astigmatism Mirrorupdate Image Analysis

  33. Biomedical images processing and analysis 6. Bio-inspired omni-directional vision Omnidirectional mirror Development ofbiomimeticalgorithmsfor vision Space variant sensorproviding with a foveated vision

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