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Drug Targets Understanding Disease at the Level of Individual Molecules

Drug Targets Understanding Disease at the Level of Individual Molecules. Claude Benchimol SVP, R&D UCSD Workshop December 9, 2005. Beyond the Genome. To come to life it must be translated into action, like a screenplay must be turned into acting. An organism's genome.

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Drug Targets Understanding Disease at the Level of Individual Molecules

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  1. Drug Targets Understanding Disease at the Level of Individual Molecules Claude Benchimol SVP, R&D UCSD Workshop December 9, 2005

  2. Beyond the Genome To come to life it must be translated into action, like a screenplay must be turned into acting An organism's genome A two-dimensional and static description of a living creature pcDNA-tubB-CFP pcDNA-nTC-actB pcDNA-FK36-rac1 The key actors are proteins

  3. Molecular Interactions: Pathway Elucidation • Life, in health and disease, is the result of proteins interacting with many other proteins … Pathways • Malfunctions in these protein interaction pathways give rise to disease. • Our new challenge is to map and understand these hugely complex pathways • This will lead to the discovery of new targets and better and safer drugs Yeast Proteome Much More to Explore!

  4. To Win the War Against Disease …. Academic & Medical Institutions Golden Triangle Tools And Technology Providers Pharma and Biotech … Teamwork and Alliances are Essential

  5. An Example of a Success Basic Research Tools Application BCR-ABL is a tyrosine kinase enzyme Pharma Research Inhibition of Kinase Enzyme Activity Identify the gene  Understand what it “codes for”  Inhibit the activity

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