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E1A binding protein p300

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

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E1A binding protein p300

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  1. EP300 E1A binding protein p300 BackgroundThis gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. SynonymsEP300; E1A binding protein p300; histone acetyltransferase p300; KAT3B; p300; p300 HAT; E1A-binding protein, 300kD; E1A-associated protein p300; RSTS2 Recombinant Proteins Cat.#Product name Source (Host) SpeciesTag Price EP300-3346H Recombinant Human EP300 Protein, GST-tagged Wheat GermHuman GST+Inquiry EP300-414HRecombinant Human EP300 Protein, His-taggedE. coli Human His+Inquiry

  2. EP300-43HRecombinant Human EP300 Protein, GST-taggedE. coli Human GST+Inquiry Ep300-415MRecombinant Mouse Ep300 Protein, His-tagged E. coli Mouse His+Inquiry Ep300-416RRecombinant Rat Ep300 Protein, His/GST-taggedE. coli Rat His/GST+Inquiry EP300-1584H Recombinant Human E1A Binding Protein P300, GST-taggedSf 9 Insect cellsHuman GST+Inquiry EP300-1585H Recombinant Human E1A Binding Protein P300, GST-taggedSf 9 Insect cellsHuman GST+Inquiry EP300-202HRecombinant Human EP300 protein, DDK-tagged Insect cellsHuman DDK+Inquiry EP300-28677THRecombinant Human EP300 protein, Flag-tagged Insect cellsHuman Flag+Inquiry EP300-28678THRecombinant Human EP300 Human +Inquiry EP300-28680THRecombinant Human EP300, FLAG-tagged Human Flag+Inquiry EP300-42HRecombinant Human EP300 proteinE. coliHuman +Inquiry EP300-442HRecombinant Human EP300, His-tagged Baculovirus-Insect Cells Human His+Inquiry

  3. EP300-610HRecombinant Human EP300Mammalian Cells Human His+Inquiry EP300-80HRecombinant Human EP300 protein, His-taggedE. coli Human His+Inquiry EP300-1481R Recombinant Rhesus monkey EP300 Protein, His-taggedMammalian Cells Rhesus Macaque His+Inquiry EP300-1074H Recombinant Human E1A Binding Protein P300, 302-531aa E. coliHuman N/A +Inquiry Involved Pathway EP300 involved in several pathways and played different roles in them. We selected most pathways EP300 participated on our site, such as cAMP signaling pathway, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EP300 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway NamePathway Related Protein cAMP signaling pathwayFXYD2; MAPK1; GRIN2C; LOC100328615; NFATC1; PTCH1; PIK3R5; ACOX1; NPR1; CNGA3 HIF- signaling pathwayNPPA; BCL2; EGLN1; EP300; IL6; MAPK3; ALDOA; INS1; PIK3CG; TCEB1

  4. FoxO signaling pathwayCDKN1BA; GABARAPA; MAPK8A; PLK3; FOXO3A; ATG12; BCL6; GADD45AA; FASLG; STAT3 Cell cycleCDC16; RBBP8; GADD45AA; PANE1; TUBG1; MAPRE1; CHEK2; CDC45; MSH4; CENPA Wnt signaling pathwayFZD8B; WNT11R; RUVBL1; NKD2; FZD7B; DAAM1; WNT8A; PLCB3; DKK1B; RAC1 Notch signaling pathwayCNTN6; PSEN2; DTX3L; DTX2; MAML1; DVL1B; NOTCH1A; KAT2A; DLK1; RBPJ TGF-beta signaling pathwaySMAD9; E2F5; TFDP1; TGFBR1B; TGFBR1; FST; LEFTY1; BMPR2B; LFT2; LFT1 Adherens junctionPTBP3; INSRA; PTPRM; FARP2; RHOA; ACTN3A; LMO7A; TJP1; TGFBR1; TGFBR2 Jak-STAT signaling pathwayIFNPHI3; PTPN2A; STAT1A; STAT6; EPO; GH1; PIK3R3; IL27RA; FHL1A; IL6R Long-term potentiationPRKCB; CAMK2G; GRIN2D; PLCB2; GRIA2; PRKCA; PPP1CB; GRM1; CALML5; CALM4 MelanogenesisFZD10; FZD7B; POMCA; GNAQ; a; FZD5; MAP2K2B; RAF1A; ADCY1A; KITB Thyroid hormone signaling pathwayHDAC1; ACTB; RXRA; BMP4; NOTCH3; AKT1; PLN; SLCO1C1; PFKFB2; PIK3R3 Glucagon signaling pathwayPPARA; PLCB3; GYS2; CAMK2B; CREB3L1; PFKL; LDHAL6A; CAMK2D; PRMT1; PDE3B

  5. Huntingtons diseaseCOX6B1; CASP9; SOD1; DNAH5; MT-ATP6; GRM5; SLC25A4; POLR2G; SLC25A5; COX5B TuberculosisRIPK2; ARHGEF12; CASP9; Ifna15; HLA-DQB1; TRADD; Casp3; TGFB1; FADD; BCL10 Hepatitis BIKBKB; STAT4; CREB3L1; IFNA17; IL-8; TP53; IFNAR1; Fasl; IFNA4; FADD Influenza AMAP2K2; RSAD2; IL12A; CASP9; EIF2AK4; SLC25A6; LOC100686744; PRSS2; TNFRSF10C; PABPN1L HTLV-I infectionCDC26; MAPK8; POLD2; HLA-DQB1; CD3E; CD3D; TBPL2; ANAPC4; TNFRSF1A; ANAPC5; RANBP1 Herpes simplex infectionC3A.3; IFNA1; MCRS1; GTF2I; HNRPK; TNFB; HLA-C; IKBKE; CASP8; SRSF7A Epstein-Barr virus infectionPSMC1; PLCG2; HDAC5; MAPK10; ICAM1; MAPK9; MAP2K7; CCNA1; PIK3CD; YWHAG Pathways in cancerRAC1; FLT3; WNT6; HRAS; TGFBR1; CCND1; IGF1; VEGFC; TCF7L2; NKX3-1 Viral carcinogenesisH2BFWT; CASP8; HIST1H2BD; REL; ATP6V0D2; GTF2A2; CREB5; TRP53; HRAS; HDAC3 MicroRNAs in cancerGLS; NOTCH2; RDX; BCL2; CCNE2; DNMT3A; CD44; SHC1; EZH2; CYP24A1 Renal cell carcinomaARNT2; MAP2K1; EGLN2; PIK3CD; RAPGEF1; HRAS; PIK3CG; FH; TGFB3; MAPK3

  6. Prostate cancerSPINK1; EP300; BCL2; MAP4K1; GSK3B; PIK3CD; ACTL6B; MTOR; KRAS; TCF7 Protein Function EP300 has several biochemical functions, for example, DNA binding, NF-kappaB binding, RNA polymerase II activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EP300 itself. We selected most functions EP300 had, and list some proteins which have the same functions with EP300. You can find most of the proteins on our site. FunctionRelated Protein Function DNA bindingRelated Protein ZBTB43; ALX4; SALL1; HOXD9A; SCML4; NACA; NFAT5A; ZNF823; GBX1; UBN2A Function NF-kappaB bindingRelated Protein GSK3B; HDAC3; DNAJA3; MTDH; BRMS1; HSPA6; BCL10; NFKBID; FAF1; HIF1AN Function RNA polymerase II activating transcription factor bindingRelated Protein POU1F1; NEUROD1; JUN; RB1; HNF4A; CREB1; IFI27; SMAD3; LDB1; TBX3 Function RNA polymerase II core promoter proximal region sequence-specific DNA bindingRelated Protein PHOX2B; PRDM1; MYOD1; NEUROG3; ZNF148; CEBPA; ZNF264; KCNA3; OTX2;

  7. HSF1 Function RNA polymerase II core promoter sequence-specific DNA bindingRelated Protein ZFPM1; NR4A2; NFIL3; PAX8; PAX6; SMYD3; HNF4A; WBP2; MAZ; SOX11 Function SMAD bindingRelated Protein FLNA; SKIA; FOXH1; DAB2; SKOR2; ACVRL1; TOB1; BMPR1A; SKOR1; SOD3 Function acetyltransferase activityRelated Protein Acnat1; AANAT1; MBOAT4; MBOAT1; AANAT2; ACNAT2; LPCAT3; HHAT; CML5; KAT8 Function activating transcription factor bindingRelated Protein RELA; PPARG; HDAC7A; MEF2A; SMAD2; DGKQ; EEF1D; HDAC1; HDAC7; HDAC4 Function androgen receptor bindingRelated Protein RNF14; DAXX; NCOA1; TCF21; KDM1A; GRIP1; PRKCBB; CTNNB1; Ar; KDM4C Function bHLH transcription factor bindingRelated Protein IKZF4; HAND1; RUNX2; MAP3K10; TCF4; USF1; SMAD3; TCF3; TCF3A; FOXH1 Function beta-catenin bindingRelated Protein FAM123B; MED12; TCF7L2; TCF7L1A; NF2; CTNNBIP1; APC2; TAX1BP3; DACT1; AXIN2 Function chromatin DNA bindingRelated Protein HIST1H1A; RXRA; PRDM14; BCL6; VAX2; H2AFY; CLOCK; INSM1A; XBP1; ZIC2

  8. Function chromatin bindingRelated Protein MEN1; FANCM; ENY2; PRDM13; PBX2; HMGB2B; NKX6; CBX4; CENPB; NOC3L Function core promoter bindingRelated Protein HMGA2; TFAP2C; IFI16; HDAC6; FOXP3; GTF2B; IRF9; PYDC3; DHX36; SFPI1 Function damaged DNA bindingRelated Protein APTX; FEN1; XRCC1; POLH; RAD18; TP73; NEIL1; RAD23AA; TRPC2; H2AFX Function glucocorticoid receptor bindingRelated Protein FKBP4; NRIP1; STAT3; STAT5B; YWHAH; GRIP1; EP300; ETS2; CEBPB; NR4A2 Function histone acetyltransferase activityRelated Protein TAF1L; NCOA3; MED24; ATF2; KAT7; KAT5; TAF1; vnc; HAT1; KAT7B Function lysine N-acetyltransferase activity, acting on acetyl phosphate as donorRelated Protein EP300; KAT2B; RHBDL1; NAT8B; ESCO2; CEACAM21; NAT8 Function mitogen-activated protein kinase bindingRelated Protein EP300; PLCB4; TPR; SIRT1; ATF7; MAPKAPK2A; ABL1; MICALCL; DUSP2; PTPRJ Function nuclear hormone receptor bindingRelated Protein TCF7L2; HIF1A; NCOA1; TACC2; NRIP1; SNW1; ACTN4; CTNNB1; Ankar; CRX Function p53 bindingRelated Protein TRIM29; ZMAT3; BRD7; TP53; HTT; RNF34; TAF1; CREBBP; EP300; MSX1

  9. Function peroxisome proliferator activated receptor bindingRelated Protein IKBKG; HMGA1; ASXL2; CREBBP; NR0B2; HMGA1-RS1; PRMT2; PPARGC1A; EP300; MED1 Function pre-mRNA intronic bindingRelated Protein RBM41; PRPF8; SOX9; HNRNPA2B1; RBM4; EP300; RNPC3 Function protein C-terminus bindingRelated Protein PHB; HSPG2; NPAT; PRKAA1; YWHAB; CTBP1; CSK; GRIP1; PLEKHB1; TAF13 Function protein antigen bindingRelated Protein KLRD1; EP300; H2-AB1; KLRC2; ITGA4 Function protein bindingRelated Protein PHYHD1; BCLAF1; JAG2; CASP2; AMBRA1; MED31; MTTP; LBX1; DNAJB4; C1QTNF1 Function protein complex bindingRelated Protein UQCRFS1; CPS1; ST13; PDZK1; GIT1; CD2AP; ARRB2; ITPR1; IGBP1; RPH3A Function transcription coactivator activityRelated Protein NR1I3; RXRA; NEUROG3; MAML1; PSMD9; NR2C2; SMARCB1; CITED1; TAF12; NPAT Function contributes_to transcription coactivator activityRelated Protein EP300; CREBBP; ARID5B; PHF2 Function transcription factor bindingRelated Protein MED25; MECP2; TRIM11; KCNA3; NAAA; TWIST1; SOX10; KAT2A; TAF7L; CEBPB Function transcriptional activator activity, RNA polymerase II

  10. transcription regulatory region sequence-specific bindingRelated Protein CTCF; MYOCD; GATA2; LEF1; FOXC1; BARHL1B; GATA4; ALX1; FEZF2; MAFBA Function transferase activity, transferring acyl groupsRelated Protein KEG1; CHATB; LPGAT1; ZDHHC18; LIPT1; GGACT.1; PDHX; ZDHHC23B; NAT14; ZDHHC5A Function zinc ion bindingRelated Protein MMP23BB; TRIM35-27; LIMS3L; RNF180; VAT1L; LIMD1; TRIM25; NR1D2B; DTNB; LIMS1 Interacting Protein EP300 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EP300 here. Most of them are supplied by our site. Hope this information will be useful for your research of EP300.

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