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SMAD family member 1

https://www.creativebiomart.net/symbolsearch_SMAD1.htm The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

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SMAD family member 1

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  1. SMAD family member 1 https://www.creativebiomart.net/symbolse arch_SMAD1.htm BackgroundThe protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] SynonymsSMAD1; SMAD family member 1; BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1; mothers against decapentaplegic homolog 1; MAD homolog 1; Mad-related protein 1; TGF-beta signaling protein 1; mothers against DPP homolog 1; SMAD, mothers against DPP homolog 1; MAD, mothers against decapentaplegic homolog 1; transforming growth factor-beta signaling protein 1; transforming growth factor-beta-signaling protein 1; Recombinant Proteins Cell & Tissue Lysates Cat.# Product name Source (Host) Species SMAD1-1916H Recombinant Human SMAD1 Protein, His-tagged E. coli Human His +Inquiry SMAD1-11H Recombinant Human SMAD1, His-tagged E. coli Human His +Inquiry SMAD1-12H Recombinant Human SMAD1, MYC/DDK-tagged Human MYC/DDK +Inquiry SMAD1-160H Recombinant Human SMAD1 Protein, His-tagged E. coli Human His +Inquiry SMAD1-161H Recombinant Human SMAD1 Protein, His-tagged E. coli Human His +Inquiry SMAD1-2799H Recombinant Human SMAD1, GST-taggedE. coli Human GST +Inquiry SMAD1-30445TH Recombinant Human SMAD1 E. coli Human +Inquiry TagPrice HEK293

  2. SMAD1-43H Human GST SMAD1-15584M Mouse His +Inquiry Smad1-657M Mouse His/T7 +Inquiry Smad1-658R His +Inquiry SMAD1-4329R Recombinant Rhesus monkey SMAD1 Protein, His-tagged Mammalian Cells Rhesus Macaque SMAD1-4493C Recombinant Chicken SMAD1 Mammalian Cells His +Inquiry SMAD1-8936Z Recombinant Zebrafish SMAD1 Zebrafish His +Inquiry SMAD1-656C Recombinant Cattle SMAD1 protein, His & T7-tagged Cattle His/T7 +Inquiry SMAD1-1092H Recombinant Human SMAD Family Member 1, GST-tagged E. coli Human GST +Inquiry Involved Pathway SMAD1 involved in several pathways and played different roles in them. We selected most pathways SMAD1 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway NamePathway Related Protein TGF-beta signaling pathwayACVR2A; TNF; FSTA; ID2; PPP2CB; INHBB; ACVR1L; ID2B; SKP1; TGIF1 Hippo signaling pathwayBTRC; PPP1CB; WNT11; BMP8A; FZD6; WNT7A; YWHAB; AFP; PPP2R2C; WNT16 Signaling pathways regulating pluripotency of stem cellsPIK3CB; MAP2K1; OTX1; PIK3R1; WNT9B; HAND1; PCGF1; FGFR1; FZD1; KRAS Transcriptional misregulation in cancerHIST1H3A; MMP3; RUNX1; CCNT1; FLT3; HDAC1; GOLPH3L; NCOR1; HIST1H3I; ARNT2 Protein Function SMAD1 has several biochemical functions, for example, I-SMAD binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD1 itself. We selected most functions SMAD1 had, and list some proteins which have the same functions with SMAD1. You can find most of the proteins on our site. FunctionRelated Protein Recombinant Human SMAD1 protein, GST-tagged E. coli +Inquiry Recombinant Mouse SMAD1 Protein Mammalian Cells Recombinant Mouse Smad1 protein, His & T7-tagged E. coli Recombinant Rat Smad1 protein, His-tagged E. coli Rat His +Inquiry Chicken Mammalian Cells E. coli

  3. Function I-SMAD bindingRelated Protein TGFB1I1; TGFBR1; SMAD4; CTNNB1; AXIN2; AXIN1; SMURF1; SMAD6; SMAD1; SMAD2 Function RNA polymerase II core promoter proximal region sequence-specific DNA bindingRelated Protein NFYC; MYF5; RFX1; NDN; PRDM1; MITFA; ELK1; FOSL2; MSX2; MAFA Function RNA polymerase II core promoter sequence-specific DNA bindingRelated Protein SPI1; TFAP2B; IRF7; HNF4A; GBX2; TRP53; H2AFZ; SOX8; SMAD5; NSD1 Function co-SMAD bindingRelated Protein CITED1; TGIF1; SMAD1; SMAD2; GATA4; TRIM33; SMAD6; SMAD3; FOXH1; USP9X Function identical protein bindingRelated Protein KCNJ2; MTSS1; CTSC; UBE4A; DAAM1; ALDOB; CEP72; CNTN2; ALAD; NCL Function metal ion bindingRelated Protein NPAS2; KLF12A; PPARG; OBSCN; GTF3AB; NKD2A; BTR30; ZFP354B; PFKM; ZNF683 Function protein bindingRelated Protein RAB3IP; UHRF1; SIRT1; NKX2-5; CALCOCO2; BCLAF1; AP2A1; DNM3; GEMIN4; RPL23 Function protein heterodimerization activityRelated Protein SYT10; HIST1H2BE; DVL3; KCNK9; HIST3H3; ADORA1; SNX6; ZFP423; PDZD7; HIF1A Function protein homodimerization activityRelated Protein ATPIF1B; MGST1; ADIPOQ; TCF3A; CSF1R; TBX18; CRYBA2; GSTZ1; DAXX; TARS Function protein kinase bindingRelated Protein Fert2; CCNT2A; TRAF2; STXBP1; ZFP36; LIPE; TP53; DOK7; SPRED2; SHC1 Function receptor signaling protein activityRelated Protein TGFBR1; DOK2; NGF; CD3E; ADRB1; DCLK1; TRAIP; GNAZ; PDCL; RGS14 Function transcription factor activity, sequence-specific DNA bindingRelated Protein TP53; POU1F1; LEF1; RARAB; ZIC5; ZNF217; NFIL3-6; GATA6; PHF5A; ELF3 Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingRelated Protein NFAT5; SRF; BSX; ELF1; TFE3B; FOXA1; SMAD2; NRF1; ISL1; FOXJ1 Function transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activityRelated Protein SMAD9; SMAD1; SMAD3; SMAD2 Interacting Protein SMAD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD1. SMAD4; GSK3B; AR SMAD1 Related Articles Kaneko, K; Higuchi, C; et al. Hyaluronan inhibits BMP-induced osteoblast differentiation. FEBS LETTERS 589:447-454(2015).

  4. Xu, LL; Liu, Y; et al. U0126 promotes osteogenesis of rat bone-marrow-derived mesenchymal stem cells by activating BMP/Smad signaling pathway. CELL AND TISSUE RESEARCH 359:537-545(2015).

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