1 / 8

Ready-to-Use Clonal Genes for Reliable Experimental Reproducibility

Our clonal genes service provides fully sequenced, vector-ready gene clones, ensuring reproducible and consistent experimental results. Get accurate clonal genes tailored to your projectu2019s vector and host system requirements.

Blue83
Télécharger la présentation

Ready-to-Use Clonal Genes for Reliable Experimental Reproducibility

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. The Power of Clonal Genes: Unraveling Disease Mechanisms Clonal genes are central to understanding cancer development. They are crucial for diagnosing hematologic disorders. They drive precision medicine with specific genetic markers.

  2. What Are Clonal Genes? Genetic Alterations Occur in a clonally expanded cell population. Somatic Mutation Originate from a single progenitor cell. Identical Daughter Cells Carry the same specific mutation. Uncontrolled Growth Driver mutations enable this cell growth. Clonal genes are genetic alterations from a single cell. They create identical daughter cells. These mutations, like driver mutations, enable uncontrolled cell growth.

  3. Clonal Genes in Cancer Development Tumor Hallmarks They are hallmarks of tumor initiation and progression. TP53 Mutation TP53 is mutated in 50% of all cancers. RAS Family KRAS, NRAS, HRAS are oncogenes in 30% of human cancers. EGFR Mutations EGFR activating mutations occur in 15% of NSCLC cases. Therapy Resistance Clonal evolution drives resistance to therapy.

  4. Clonal Hematopoiesis of Indeterminate Potential (CHIP) Key Characteristics Associated Risks Common mutations: DNMT3A, TET2, ASXL1, JAK2.

  5. Diagnostic Applications: Detecting Clonal Signatures NGS ddPCR Sanger Next-Generation Sequencing (NGS) is the gold standard for detection. It identifies mutations with high sensitivity. It's used in cancer prognostication. Liquid biopsies detect circulating tumor DNA for monitoring. This enables early detection and risk stratification for CHIP.

  6. Therapeutic Implications: Targeting Clonal Genes 70% 40-60% 42% EGFR Inhibitors JAK2 Inhibitors IDH Inhibitors Response rate for EGFR-mutated NSCLC. Reduces spleen size in MPN. Complete remission rate for IDH-mutated AML. Precision medicine tailors treatments to specific mutations. EGFR inhibitors, like Osimertinib, are used for EGFR-mutated NSCLC. JAK2 inhibitors, such as Ruxolitinib, are effective for MPN. IDH inhibitors, like Ivosidenib, are used for IDH-mutated AML. This identifies patients likely to respond to specific therapies.

  7. Future Directions in Clonal Gene Research 1 Early CHIP Detection Aim to mitigate disease progression. 2 Novel Therapies Development for rare mutations is ongoing. 3 CRISPR Gene Editing For correcting somatic mutations. 4 Therapy Resistance Understanding clonal evolution in resistance. 5 Personalized Prevention Strategies based on clonal risk.

  8. Conclusion: The Evolving Landscape of Clonal Genes Clonal genesare fundamental to understanding disease pathology. They drive advancements in diagnostics and personalized treatments. They hold immense promise for future precision medicine. Continued research is essential for improved patient outcomes.

More Related