Travis Rush: A Purpose-Driven Leader Making Healthcare Easy and Accessible with

1. The Most INSPIRING Healthcare Entrepreneurs To Watch In 2024 Advancements in the U.S. Bladder Scanners Market Global Events of Health Tech Advancements in Biometric Screening: Enhancing Security and User Experience TRAVIS RUSH REPERIO HEALTH CEO A Purpose-Driven Leader Making Healthcare Easy and Accessible with Tech Innovation

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3. The Lifesciences Magazine, 1985, Henderson Rd, Columbus, Ohio, 43220 Follow Us On: For Editorial Concerns: editors@thelifesciencesmagazine.com For Sales & Branding Enquiries: matthew@thelifesciencesmagazine.com For Subscription: info@thelifesciencesmagazine.com Publisher Business Development Executive Susan Wilson The Lifesciences Magazine Creative Content Editor Shalmali W. Creative Designer Paul Young Marketing Coordinator (USA) Matthew Eden Social Media Manager Amy Muller Digital Circulation Manager PR & Marketing Coordinator Michael Stevens Amanda V. This list is NOT a ranking. The companies on listed in magazine serve different aspects of the market, making ranking them in any order except revenue impossible and unfair. We try to bring a perfect platform for business organization to showcase their valued products/ services. Copyrights © The Lifesciences Magazine All Rights Reserved. The images and content included in this magazine should not be copied, transferred or reproduced in any form or by any means, electronics, mechanical, photocopying, recording, otherwise, without proper permission from The Lifesciences Magazine. The Lifesciences Magazine solely owns all the reprint rights.

4. FROM EDITOR’S DESK Welcome to the latest issue of Lifesciences Magazine, where we shine a spotlight on “The Most Inspiring Healthcare Entrepreneurs To Watch In 2024.” As we embark on a new year, the healthcare landscape continues to evolve at an unprecedented pace, driven by the relentless innovation and visionary leadership of entrepreneurs who are reshaping the industry. In this issue, we celebrate Travis Rush (Co-founder & CEO of Reperio Health), whose groundbreaking work is not only advancing medical science but also transforming patient care. Such entrepreneurs are leveraging cutting-edge technologies, from artificial intelligence to biotechnology, to address some of the most pressing health challenges of our time. His ventures span diverse areas, including precision medicine, digital health, and sustainable biopharma solutions, each contributing uniquely to the healthcare ecosystem. As we navigate the complexities of the modern healthcare environment, entrepreneurs like Travis remind us of the importance of resilience, creativity, and a relentless commitment to improving lives. Their journeys inspire us to envision a future where healthcare is more efficient, equitable, and personalized. We invite you to delve into his stories, learn from his experiences, and be inspired by his achievements. Together, let’s celebrate this trailblazer who is not only shaping the future of healthcare but also setting a benchmark for what is possible through ingenuity and determination. Thank you for joining us in this celebration of excellence and innovation. Here’s to a year of remarkable advancements and transformative healthcare solutions. halmali S Shalmali W.

5. REDEFINING THE SCIENCE OF LIFE The Lifesciences Magazine is global healthcare solutions platform that paves the way for various healthcare innovations, advices of professionals.

6. Leaders in Spotlight The healthcare industry presently requires leaders like Travis Rush (CEO & Co-Founder of Reperio Health), who exemplify innovation, adaptability, and a consumer-centric mindset to navigate the complexities of modern healthcare. By challenging traditional norms and advocating for at-home solutions, Travis addresses the need for greater efficiency and convenience in healthcare. He is a purpose-driven leader whose visionary leadership serves as a ray of hope for creating a more modern healthcare ecosystem. He spearheads Reperio Health at the forefront with a mission to simplify preventive care services for everyone. Travis has extensive experience in web application development, with over 25 years in the industry. He founded Sightbox, an inclusive vision care solution that caught the attention of Johnson & Johnson, leading to its acquisition in 2017. Additionally, he is the founder and owner of Lucky Lab Studios, a recording studio and record label, where he pursues his passion for music and creativity. Travis previously owned Rushweb Solutions, a company focused on website development, search engine optimization (SEO), and dedicated hosting services, which he later sold. He established Reperio in 2019, a company providing biometric screening services both onsite and at home.

7. 10. COVERSTORY Travis Rush contents 20. ARTICLE Advancements in Biometric Screening: Enhancing Security and User Experience 24. MARKET RESEARCH REPORT Advancements in the U.S. Bladder Scanners Market 28. ARTICLE Tech Innovations Reshaping Mental Health: A Glimpse into the Future 32. GLOBAL EVENTS Global Events of Health Tech 36. ARTICLE Robot-Assisted Surgeries: Advantages and Drawbacks of AI in Healthcare 40. NEWS OF THE WEEK

10. Travis Rush A Purpose-Driven Leader Making Healthcare Easy and Accessible with Tech Innovation Travis Rush | CEO Reperio Health In today’s world, fostering a healthcare ecosystem that is more equitable and responsive is paramount. This kind of healthcare system prioritizes patient-focused care tailored to individual needs, ensuring fair access to quality services for all, particularly in the rapidly changing post-pandemic landscape. The healthcare industry presently requires leaders like Travis Rush (CEO & Co-Founder of Reperio Health), who exemplify innovation, adaptability, and a consumer-centric mindset to navigate the complexities of modern healthcare. By challenging traditional norms and advocating for at-home solutions, Travis addresses the need for greater efficiency and convenience in healthcare. He is a purpose-driven leader whose visionary leadership serves as a ray of hope for creating a more modern healthcare ecosystem. He spearheads Reperio Health at the forefront with a mission to simplify preventive care services for everyone. 10

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13. Cover Story Recognizing the True Spirit of Entrepreneurship receive real-time information on their mobile devices. After use, the kit is returned for sterilization, consumable replacement, and allocation to another individual. With 25+ years of experience, Travis boasts a substantial career. During college, he decided to drop out in his junior year, recognizing that the traditional academic path did not align with his vision. His passion, both then and now, lies in creating innovative solutions to simplify business processes and enhance people’s lives by leveraging technology. This innovative approach differs from the inconvenience of traditional biometric screenings in labs or offices. The conventional method often requires taking time off work, arranging childcare, and managing transportation, leading to a significant percentage of the population skipping screenings. Reperio Health aims to transform access to health screenings, offering a more convenient and swift method for individuals to obtain essential health information. In 1997, Travis founded a web development company, crafting websites for businesses nationwide, a journey which later evolved into focusing on healthcare, particularly in the eye care sector and influenced by his family’s background in optometry. Drawing on his familiarity with the field, he developed websites for optometry practices and later transitioned into creating specialized applications for e-commerce and fulfillment. After successfully selling a company called Sightbox to Johnson & Johnson in 2017, Travis turned his sights into preventive health and founded Reperio in 2020. Creating and Growing–One Step at a Time At the helm of Reperio, Travis wears multiple hats throughout the day and undertakes several responsibilities to keep the company ahead of the curve. While navigating the challenges of building something is tricky, he acknowledges this in his journey of creating and growing a company. Moreover, it gets complicated because decisions need to be made in unfamiliar territory with limited information. Firstly, managing the company’s growth and creating a strategy that aligns with that growth is one of the main challenges. Hence, Travis finds that the toughest part of building companies is striking the right balance between speed and caution. Moving too quickly without a strong foundation can lead to problems, a common pitfall when companies overestimate their growth ability. To address this, Reperio Health prioritizes careful planning, forward-thinking, and forming a team with diverse experiences. Being a recognized and established leader, Travis recognizes the responsibility of entrepreneurship, understanding its impact on both his team and the broader business landscape. With a history of successful ventures, including two acquisitions, Reperio Health’s four-year operation has shown accelerated growth, emphasizing its positive trajectory in the evolving healthcare landscape. Travis remains dedicated to overcoming entrepreneurial challenges and ensuring the company’s continued success. Simple and Convenient Healthcare Services for All Secondly, trusting the team is vital, and Travis highlights the importance of giving responsibilities to those with the right expertise. Despite the certainty of mistakes, he encourages a culture that values trying new things. The philosophy revolves around supporting innovative attempts and understanding that both successes and failures provide valuable insights. Travis doesn’t believe in punishing team members for mistakes but encourages and appreciates efforts to explore new areas. Under his leadership, Reperio aims to create a culture where everyone feels empowered to try, acknowledging that even unsuccessful attempts contribute important lessons. Reperio Health was created to address strain and inefficiency in the healthcare system and bring convenient screening solutions to consumers, employers, and providers. Today, the company’s flagship wellness kit includes tests to calculate blood pressure, heart rate, BMI, relative fat mass, and a comprehensive lipid panel covering total cholesterol, LDLs, HDLs, triglycerides, and glucose. The company’s at-home and onsite biometric health screenings enable individuals to follow a consumer- friendly, self-directed app experience so they can take charge of their health. Nevertheless, the core message is evident: taking risks and challenging conventional methods is crucial for positive change. Travis believes that sticking to safe, predictable approaches doesn’t lead to transformative advancements. To make a meaningful impact and change the world, he insists on defying conventional norms and striving for improvement, even if it means stepping into uncharted territory. The revolutionary part of Reperio’s service is that these tests provide instant results. The process involves sending the screening kit to individuals’ homes, where screenings can be completed within 30 minutes. Instant results eliminate the need to send samples to a lab, reducing the waiting time associated with traditional methods. Users www.thelifesciencesmagazine.com | 13

14. Cover Story The Dual Nature of Technology Building Blocks of Tomorrow’s Healthcare In this digital era, Travis believes technology is a blessing as well as a challenge. While not every issue can be resolved with technology alone, he emphasizes the importance of a thoughtful approach in integrating it into the company’s operations, where the key lies in identifying labor-intensive bottlenecks that hinder business efficiency. Travis embarked on a mission to improve lives by addressing a global challenge—how to tackle chronic diseases proactively. Recognizing cardiovascular disease as a pervasive threat worldwide, especially in the US, he saw an opportunity to empower individuals to take charge of their health. The COVID-19 pandemic laid bare the vulnerabilities of the healthcare system, prompting a realization that relying solely on the overwhelmed system was not sustainable. The focus shifted to putting healthcare directly in the hands of individuals. Every decision made by Reperio Health revolves around simplifying the process for individuals, not just for the convenience of the healthcare system. The groundbreaking technology developed by Reperio Health is the first of its kind globally, embodied in its health screening kit. The uniqueness of the technology, though a challenge due to its unprecedented nature, resulted in Reperio Health securing a patent in the US, with pending patents in 26 other countries. The ultimate goal is to empower individuals to regularly monitor their health from the comfort of their homes, without time- consuming appointments or visits to traditional healthcare facilities. Taking a systematic stance, Travis believes in first understanding the specific problems causing bottlenecks before leveraging technology to streamline processes. He acknowledges the risk of over-engineering, a pitfall he has encountered. Overcomplicating tasks with technology, especially when manual efforts could suffice, can be counterproductive and costly. He further adds that technology becomes valuable when supported by data-driven insights. Merely developing technology without a clear purpose or rationale can lead to wasted resources and potential harm to the business. Thus, it is important to balance utilizing technology for efficiency gains and recognizing situations where manual processes and human input are more appropriate. In such a case, a pragmatic approach is imperative to ensure that technology serves a purpose and aligns with the needs of Reperio without unnecessary complexity or over-reliance on automated solutions. Travis’s experience growing up in a small town without easy access to biometric screenings fueled his commitment to providing accessible healthcare solutions. Reperio Health’s approach aims to bridge the gap for those who have historically faced challenges accessing healthcare services, setting a new standard for at-home healthcare. Reperio Health’s innovative technology is already making strides, prompting organizations to rethink and adapt their business models to align with this transformative approach. The vision is clear—Reperio Health’s solution is poised to redefine at-home healthcare, making proactive health management accessible to everyone, irrespective of their geographical location or existing healthcare access. “I’m very optimistic. Our team is excited about how we believe we will change healthcare forever,” adds Travis. 14

15. Healthcare at Home: A Current Necessity The impact of Reperio Health’s efforts is becoming evident as significant collaborations with major players in the healthcare industry take shape. Recognizing the inevitability of the shift towards at-home healthcare, these prominent companies are aligning themselves with this transformative change. Reperio Health envisions itself as a widely recognized entity in the at- home healthcare space in the next five years. With a growing clientele, it anticipates becoming a cornerstone in the global healthcare landscape. The expectation is not just for individuals to embrace Reperio Health’s solutions but to witness a broader demand for similar services prioritizing convenience and home- based healthcare. Foreseeing a paradigm shift, Reperio Health believes people will challenge the traditional model of making appointments and visiting healthcare facilities. Instead, there will be a growing preference for delivering healthcare services directly to individuals’ homes, fostering comfort and accessibility. Travis believes the key lies in the at-home approach. In today’s context, various aspects of life, from shopping to banking, have shifted to our homes. This trend is also evident in healthcare, although the transition is happening at a slower pace. Recognizing the societal changes of recent years, there’s a growing realization within the healthcare industry that delivering healthcare at home is a future possibility and a current necessity. The shift towards providing healthcare services where people live and work is becoming increasingly imperative. Travis sees this as a vital adaptation for the healthcare sector, aligning with the broader shift in societal behavior. The focus is finding diverse and effective ways to bring healthcare services directly to individuals, meeting them at the core of their daily lives and activities. This acknowledgment is not a distant consideration; it’s a pressing need that the healthcare industry must address promptly. The coming years are anticipated to bring remarkable positive changes, and Reperio Health is enthusiastic about playing a significant role in this transformative process. The goal is to contribute to a future where at-home healthcare becomes the norm, meeting individuals’ evolving needs and preferences worldwide. www.thelifesciencesmagazine.com | 15

16. Take Charge of Your Health Story” “ Given the vastness of the industry, modern-day healthcare providers must be well-acquainted with the current dynamics to function better and offer optimum services and solutions to those in need. In contemplating change in this eld, Travis advises those considering it to expect resistance from entrenched practices in healthcare. While many may insist on the status quo, citing the long-standing ways of doing things, he challenges this, asserting that the duration of a practice doesn’t necessarily equate to its effectiveness. His counsel is straightforward: don’t accept rejection easily. Stand rm if you believe in a better way based on your personal healthcare experiences. Travis founded his business because he dislikes the traditional method of annual health checkups in labs or doctor’s ofces. He advocates for empowering individuals with the tools to manage their health independently. In his view, consumers deserve control over basic health data, enabling them to track trends without relying solely on licensed professionals. Travis suggests adopting a consumer perspective to bring substantial change to healthcare, not adhering solely to the industry’s limited viewpoint. Individuals like him must challenge the established norms and assert control over their health decisions. His message is clear: You don’t have to be a licensed expert to understand the basics of your health. Travis envisions a world where individuals are handed the tools to manage their well-being independently. He’s not just challenging the system; he’s reshaping it from a consumer’s viewpoint, not bound by the healthcare industry’s narrow vision. So, remember Travis and others like him the next time someone tells you it can’t be done differently. It’s not just about disrupting but empowering individuals to take charge of their health story. 16

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20. What Factors Are Included in a Biometric Screening? When performing a biometric screening on a patient, clinicians: Draw blood to check for cholesterol, glucose, and triglycerides. Capture the resting blood pressure. Record weight, height, waist circumference, and other BMI measurements. A biometric screening, also known as a biometric assessment, is a routine clinical screening curated specially for employees at a company’s workplace or in cases of a commercial lab facility. This routine check-up is ideally used to monitor one’s health conditions like heart disease and diabetes. Employers usually request biometric assessments to provide a basic and foundational health assessment of their workplace. These screenings also help them to monitor any emerging health conditions that could lead to any other more serious health conditions. Especially for employers in an industry that requires physical labor, a biometric screening greatly enhances the safety of the workers. It helps them to keep a check on the employees’ health by detecting any warning signs of chronic conditions that may later contribute to work-related injuries and accidents. Here is a comprehensive guide about biometric screening and why it can prove to be beneficial for you and your employees. Ÿ Ÿ Ÿ What Can You Find in a Biometric Screening? The main role a biometric screening does is it tell the employees about their health. This includes: If they are clinically diagnosed as obese. If they have any risk of cardiovascular disease. If they have any risk of sleep apnea. If they have any risk of diabetes. Ÿ Ÿ Ÿ Ÿ After the biometric assessment, most employees will receive health information with the findings of their screening. What can you expect from a biometric screening? A biometric screening typically lasts only 15 to 20 minutes. During the procedure, you can expect the following: Your height would be measured by a healthcare professional. They might measure your hip and waist size with tape. A blood pressure cuff will be placed around your arm to measure your blood pressure. Blood samples would be taken from your prick or vein using a needle. You might have to fill out a questionnaire regarding your medical history or any medical concerns. Ÿ Ÿ Ÿ Ÿ Ÿ 20

21. Do Employers Have Any Benefits from Biometric Screening Advancements in Biometric Screening: Enhancing Security and User Experience Biometric screenings offer employers the collected data on their employees’ overall health. It helps to make adjustments in health plan benefits and address the health issues of the employees. In addition to this, employers can get some additional benefits from biometric screening. Here are some extra advantages: Saved Time and Money: The productivity of businesses can be decreased due to employees’ illness. Biometric screening helps to save time and money by promoting healthier choices among employees. With the results of biometric screening, employees can start making healthier decisions. This results in fewer sick days and improved productivity at work. Ÿ How to prepare for a Biometric Screening? Stay hydrated: Heightened Morale: Disengaged employees cost the USA $450-500 billion because of loss of productivity. When the employer performs a biometric screening, this shows that the employer cares about the welfare of the workers. Besides possibly enhancing team unity and involvement, this may also help a company benefit from showing concern. Ÿ Keep yourself well-hydrated as the phlebotomist needs to find your veins when taking a blood sample. Identify Disease & Illness in its Early Stages: Early detection of diseases can help employers and employees take action against it and address the health issue before it becomes serious. This may lead to early involvement, significantly saving employers money over time. Preventing illness and diseases can result in lower claim costs, fewer accidents, enhanced safety, and improved durability of the workforce. Ÿ Dress comfortably: Wear comfortable clothes that give quick access to your arm for checking blood pressure or drawing blood used in tests. Where’s the screening done? Take your medications as usual: Employers often hire a specialized agency to do screening which could involve onsite screening or a separate location. They could also give a kit to carry out the screening at home or have the screening done by your usual doctor in his/her clinic. Take your medications as directed by your physician unless instructed otherwise by your employer. Refrain from exercise for 12 hours: When do you get the results? Within moments you might get some or all results from your biometrics tests. Yet in case of blood samples being taken for further examination, the period will be at least a week or longer. The results would be sent through emails or courier depending on what the client prefers. Avoid taking part in any strenuous physical activity twelve hours before your screening except by the opinion or under instruction from such screening firms. www.thelifesciencesmagazine.com | 21

22. Future Trends and Innovations: Artificial Intelligence (AI) and Predictive Analytics: Remote Monitoring and Telehealth: Advances in wearables, telemedicine platforms, and remote monitoring devices allow for continuous health monitoring in real-time and virtual consultation thereby enhancing user accessibility. Risk stratification, early disease detection, and personalized health recommendations using AI algorithms and predictive analytics in biometric screening data analysis. Genomics and Precision Medicine: Mobile Health (mHealth) Applications: Increasing availability of mobile health applications (mHealth apps) that monitor biometric data, engage in health coaching, facilitate medication adherence, and support lifestyle management, encouraging patient responsibility, connection, and commitment to wellness targets. The progression towards personalized medicine incorporation of genetic testing, biomarker analysis, and personalized treatment plans based on individual genetic maps results in optimized health outcomes and prevention measures. 22

24. Advancements in the U.S. Bladder Scanners Market This segment covers various bladder scanning devices available in the market, including wireless, tabletop, and portable handheld scanners. These devices are primarily used in healthcare settings for urine assessment and guiding catheterization procedures. They provide non-invasive measurement of bladder volume and are used by a variety of end users such as urology offices, clinics, long-term care homes, ambulatory surgery centers, and hospitals. Healthcare professionals specializing in urological care, such as urologists, nurses, and primary care physicians, use bladder scanners for purposes like assessing postoperative urine retention, monitoring bladder function in patients with neurological conditions, and guiding catheterization procedures. The advancements in bladder scanning technology include improved accuracy, portability, user-friendliness, wireless connectivity, and integration with telemedicine platforms and electronic health records (EHRs). The U.S. Bladder Scanners Market, along with the ECG Patch and Holter Monitor Market, reached a valuation of USD 149.49 Million in 2023 and is projected to reach USD 217.46 billion by 2030, exhibiting a CAGR of 5.50 percent during the forecast period. This analysis provides insights into market revenues across key regions, segmented into individual countries for comprehensive understanding. Table Of Contents Ÿ Executive Summary Ÿ Research Scope and Segmentation Ÿ Market Tends Ÿ Market Assessment Ÿ U.S. Market Analysis Ÿ Competitive Assessment Ÿ Market Players Assessment 24

25. Factors Fueling Growth in the Bladder Scanners Market in the United States The rise in urinary conditions has spurred greater demand for bladder scanners to ensure accurate diagnosis and treatment. Technological advancements like 3D imaging, wireless connectivity, and portable handheld devices in ultrasound technology are enhancing the precision and user-friendliness of these scanners, contributing to market growth. Non-invasive diagnostic methods are gaining popularity, with bladder scanners providing a crucial tool for assessing bladder volume without the need for catheterization, thus driving industry expansion. The aging population, prone to urinary issues, further fuels the need for bladder scanning devices for monitoring and diagnostic purposes. Recent advancements in the U.S. bladder scanners market: Recent developments in the U.S. bladder scanners market involve key players like Vitacon US, LLC, focusing on product innovation and market expansion. The acquisition of C. R. Bard, Inc. by Becton, Dickinson, and Company has led to improved urological care through enhanced product integration. Medline Industries, Inc. has also made strategic changes to improve patient care standards within its bladder scanner offerings. 1. Why do people utilize bladder scanners? Urine retention assessment, postoperative urine retention evaluation, bladder function monitoring in patients with neurological disorders, and catheterization procedure guidance are only a few of the clinical uses for bladder scanners. 2. Bladder scanners: who uses them? Healthcare workers who provide urological care, such as nurses, urologists, primary care physicians, and other medical personnel, employ bladder scanners. Hospitals, clinics, long- term care homes, and urology offices are typical places to find them. 3. Are devices that scan the bladder safe? The usage of bladder scanners by patients is regarded as safe. They don't involve the insertion of any tools into the body and are non-invasive. To guarantee precise and safe functioning, however, appropriate training and attention to product instructions are crucial. www.thelifesciencesmagazine.com | 25

28. Tech Innovations Reshaping Mental Health: A Glimpse into the Future The world is becoming aware of various mentalities. Depression, anxiety, stress, and burnout are gaining much-needed recognition day by day. There are numerous stigmas revolving around these illnesses. These stigmas are irradiating with the rise in awareness. there a way in which we could utilize these 4 hours to benefit our mental health? Here are a few developing Tech innovations that can reshape our mind’s health. apps to assess, support, regulate, and continuously monitor our mental health. How do these apps work? All the mhealth apps contain various features that help us regulate integrants that affect our mental health. These integrants are our mind, sleep, moods, external triggers, and stress levels. Features in these apps, like meditation music, mood trackers, trigger records, and journals, help us keep our mental health on track. Some of these apps also provide digi-therapy options to users. These apps target multiple psychological disorders. That is why, the apps can be categorized based on their design and functionality. The National Institute of Mental Health (NIMH) has classified health apps into six categories. Some famous apps in these categories are: Emerging mental-health apps: Keeping track of your mental health is extremely difficult in these hectic times. We often overlook our emotions and skip our routine self-care activities. How do we find the time to improve our condition? Various coping mechanisms can help you fight different mental health illnesses. It is essential to maintain our mental health before a disorder comes to grasp us. We can use these mechanisms to keep our mental health in check. Each mechanism uses different types of tools to help patients heal. One such tool is technology. Technology has entered all spheres of the world. It has entered into the mental health domain as well. Did you know- an average person spends almost 4 hours on his phone? So, is The answer is not quite complicated; it is just three alphabets put up together- app. We use different apps in our day- to-day life. We can easily order essentials and groceries, buy clothes, purchase electronics, and even connect with our friends who, reside across the seven seas. Now, we can use various 28

29. 1. Woebot: Woebot is an AI platform launched as a digital companion to provide chat-based therapy. This therapy is based on Cognitive Behavioural Therapy (CBT), which helps users identify and change negative thought patterns. AI-powered therapy chatbots: AI-powered therapy chatbots, also known as therapy chatbots, are conversational AI therapists that may assist psychotherapists, psychologists, and other healthcare providers. It understands human mental health problems with the help of NLP (Natural Language Processing) by reading our problems first and suggesting some solutions in exchange. These chatbots can provide you with a journaling experience where your journal could give solutions to your problems. Healthcare practitioners are looking forward to these AI therapists as it can aid them in treating the initial stages of anxiety, depression, PTSD, or other mental health issues. Therapy chatbots can provide- efficient, low-cost, and timely treatment to patients. Other benefits include 24/7 service and customized therapies. Patients who are scared to open up can use these therapies initially. However, this therapy is advised only for entry-level patients. Its lack of medical ethics and standards, vague rules, and restrictions to detect and reveal a diagnosis are some of its weaknesses that chatbots will have to overcome. These AI therapists cannot diagnose your problems accurately or prescribe medication. These chatbots should be used adjacent to face-to- face therapies and not as a replacement for them. Some popular AI-powered therapy bots are: Self Management apps: Calm, Moodt, MoodKit, Headspace. 2. Wysa: Wysa is an AI-based therapy platform used to treat patients with mild symptoms of anxiety, depression, and stress. United Kingdom’s National Health Service is using this service to treat depression, anxiety, and stress among teens and young adults, including patients stuck on the waitlist. The platform also provides patients with the option to connect with a human coach or therapist on a one-to-one basis. Cognition Improvement apps: Stop, Breathe and Think, Insight Timer, 10% Happier. Skills-training apps: Daily Yoga, Sololearn, CogniFit. Social Support apps: Happify, PTSD coach, Mee Too, Sanvello. Symptom Tracking apps: Key Specs, Worry Watch, eMoods Bipolar Mood Tracker. Passive Data Collections apps: Shine, Calm Harm, MidShift. www.thelifesciencesmagazine.com | 29

30. Use of games: 2. Evo: People’s mental health has suffered the most after the lockdown. Various external factors like recession, unemployment, and inflation are increasing the adult’s stress levels. Internal factors like loneliness, overthinking, and fear of being alone have made things worse. Evo is a mental health therapy game that was developed by Akili Interactive Labs. This app offers fun activities on a mobile device that helps older adults deal with depression. The game aims to rebuild adult attention and focus with the help of scientifically constructed play sessions. Healthcare practitioners are overworking globally to meet mental health requirements. The patient’s reduced attention span and commitment have made things tough even for the therapists. Most of the patients are scared to open their hearts out. These problems are faced by adults and kids alike. Various entrepreneurs have tried to come up with a solution to this problem. One such solution brought therapies and gaming together. Using games to track, monitor, and regulate mental health has brought an effective and fun manner to manage all your mental health problems. Two popular games released recently are: 1. EndeavorRx: EndeavorRx uses a non-pharmacological approach that is powered by the company’s patented Selective Stimulus Management Engine (SSME) technology. It is a personalized and adaptive app that has become a part of the multimodal treatment of pediatric ADHD. This game is an FDA-authorized prescription digital therapy. The app aims to reach and support your cognitive process involved in attention function. The game monitors the patient's progress. It adjusts the difficulty levels and speed based on this progress. The game is inspired by children’s interest in playing games. The children are treated through this video game. While the game is no different than any other children’s game, an algorithm is working behind the scenes of the game that strengthens the kid’s neural pathways. Racing through worlds and capturing creatures will help kids with attentional control. Conclusion: These were the latest upgrades in the world of mental health technology. This technology is reshaping the mental health of numerous teenagers and adults across the globe. Apart from these, many other technologies are being introduced daily. One such interesting use of technology in therapy is the introduction of virtual reality. Patients are given a VR and experience various activities in real-time. This treatment can be given to patients to help them overcome various phobias. The activities are planned and controlled by the therapists themselves. Tech innovations are helping patients to gain efficient, low-cost, and speedy therapy. This timely treatment will help patients to recover and excel in life. 30

32. Global Events of Health Tech Ÿ The International Conference on Digital Health and Telemedicine Ÿ The Digital Healthcare Innovation Summit (DHIS) The International Conference on Digital Health and Telemedicine is scheduled to take place in Milan, Italy, from August 12th to 14th, 2024. The conference will focus on the theme "Transforming Healthcare through Digital Health and Telemedicine" and will bring together global experts, industry leaders, and healthcare professionals to discuss innovative strategies, technologies, and research in this field. Attendees can look forward to engaging sessions such as keynote presentations, workshops, panel discussions, and case studies designed to provide practical insights and evidence-based solutions. The conference aims to emphasize the importance of digital health and telemedicine in modern healthcare, with a focus on revolutionizing healthcare delivery and improving outcomes. In addition to the intellectual exchange, participants will have the opportunity to experience Milan's vibrant culture, innovation, and history, and to make valuable connections to contribute towards advancing healthcare globally. The Digital Healthcare Innovation Summit (DHIS) in Boston, MA, brought together industry leaders and professionals from various sectors to discuss critical topics shaping the landscape of digital healthcare innovation. Participants explored the impact of election results on digital healthcare innovation, addressed issues such as provider burnout and macro trends in payors and providers, and discussed the transformative potential of AI in healthcare. Strategies for navigating uncertain times for startups, challenges faced by underserved populations, regulatory changes, policy shifts, and advancements in women's health were also key focal points of discussion. The event featured panels, breakouts, and networking opportunities, allowing attendees to connect with investors, startups, tech companies, payers, providers, and advisors. DHIS was recognized as a premier boutique digital health event driving innovation in healthcare by fostering collaboration, sharing insights, and catalyzing positive change within the industry. Date: 12-14 August 2024 Location: Milan, Italy Date: 5-6 June 2024 Location: Boston, MA 32

33. Ÿ Health.tech (formerly Bits&Pretzels HealthTech) Ÿ HealthTech Forum The HealthTech Forum is an important event that brings together leaders and decision-makers with a shared goal of driving patient-centered innovation in healthcare technology while also addressing concerns about reliability and data security. Attendees can expect to meet national and global business leaders, innovators, and medical professionals, offering a diverse perspective on the industry's challenges and opportunities. Participation in this event will provide attendees with a deep understanding of the digital forces shaping healthcare and the opportunity to contribute to future strategies. With over 20 industry speakers, 15 sessions, and 150 healthcare executives in attendance, this full-day event offers a packed agenda with valuable insights and networking opportunities. The HealthTech Forum encourages discussions and collaborations aimed at advancing healthcare through technological innovation and patient-centric approaches. This conference serves as a gathering place for pharmaceutical and technology companies, MedTech professionals, and policymakers. It attracts over 2500 attendees, including 1200 executives, 400 investors, and 100 exhibitors. With a focus on startup founders, this event offers numerous collaboration opportunities. It features discussions, technology demonstrations, and ideas related to healthcare innovation. Attendees can expect to meet investors, increase brand visibility, expand professional networks, form partnerships, and share ideas with other founders. The event's dynamic atmosphere encourages creativity, connections, and advancements in the healthcare industry, making it a valuable experience for those interested in driving innovation and progress in healthcare. Date: 5-6 June 2024 Location: Munich Date: 1 August 2024 Location: Sydney, Australia Ÿ Intelligent Health Summit 2024 The Intelligent Health Summit stands out as the premier global gathering solely dedicated to AI in healthcare, attracting luminaries from various sectors, including pharmaceuticals, biotech, MedTech, health provisions, clinicians, tech companies, startups, investment, and science. This seventh edition marks a significant leap forward, breaking conventions and reshaping the summit's focus to emphasize impactful innovation. Intelligent Health distinguishes itself by assembling individuals driven by passion and a shared vision for the safe integration of AI in healthcare, all united under the common goal of enhancing global health outcomes. The summit catalyzes in-depth discussions, collaborative endeavors, and technological advancements that aim to revolutionize healthcare delivery and benefit humanity at large. Date: 11-12 September 2024 Location: Europe www.thelifesciencesmagazine.com | 33

36. Robot-Assisted Surgeries: Advantages and Drawbacks of AI in Healthcare offering a spectrum of benefits and raising critical considerations. As we navigate the advantages and drawbacks of Robot-Assisted Surgeries, it becomes evident that this technological leap is reshaping the landscape of healthcare. Here are the Advantages of Robot-Assisted Surgeries: Artificial Intelligence (AI) has seen a radical transformation in the healthcare industry in recent years, especially when it comes to surgical procedures. Advances in artificial intelligence have led to a rise in the use of robot-assisted surgeries, which offer improved patient outcomes, reduced recuperation periods, and increased precision. This essay explores the complex field of robot-assisted surgeries, highlighting both its benefits and limitations in the context of contemporary medicine. 1. Precision and Accuracy Robot-assisted surgeries leverage AI algorithms to enhance precision and accuracy. The robotic systems, controlled by skilled surgeons, allow for minute and controlled movements, reducing the risk of human error in delicate procedures. Introduction: Robot-assisted surgeries represent a groundbreaking intersection of cutting- edge robotics and medical science. The integration of AI in surgical procedures has revolutionized the traditional approach to operations, Precision and accuracy stand as the cornerstones of Robot-Assisted Surgeries, 36

37. ushering in a new era of surgical capabilities. AI algorithms intricately guide robotic systems through procedures, empowering surgeons to execute minute and controlled movements with unparalleled finesse. comfortable experience while maintaining the efficacy of the procedures. shift in healthcare delivery. This innovative approach allows surgeons to conduct procedures on patients situated at a distance, transcending geographical constraints. 3. Enhanced Visualization AI-powered robotic systems provide surgeons with advanced visualization capabilities. High-definition 3D imaging offers a detailed view of the surgical site, enabling surgeons to navigate complex anatomical structures with heightened clarity. With the aid of robotic systems controlled by skilled surgeons, remote surgery becomes a reality, ensuring that specialized expertise can reach patients in diverse locations. This breakthrough not only enhances accessibility to healthcare services but also opens new frontiers for collaboration and the dissemination of surgical expertise. This not only minimizes the risk of human error in intricate surgeries but also opens avenues for previously unimaginable levels of precision. As the marriage of AI and surgical robotics advances, the potential for even more refined and delicate procedures emerges, promising groundbreaking advancements in medical interventions. The integration of AI into Robot- Assisted Surgeries brings forth enhanced visualization capabilities that redefine surgical precision. High-definition 3D imaging elevates the surgeon’s perspective, offering an intricate view of the surgical site. This heightened clarity allows for meticulous navigation through complex anatomical structures. Surgeons, empowered by this advanced visualization, can make informed decisions and execute procedures with unparalleled precision. 5. Reduced Blood Loss and Infection Rates 2. Minimally Invasive Procedures Precise control and smaller incisions contribute to reduced blood loss during surgeries. Additionally, the minimally invasive nature of these procedures decreases the risk of postoperative infections, enhancing overall patient safety. The use of robotic arms and instruments in surgeries enables minimally invasive techniques. Smaller incisions result in reduced trauma to the patient’s body, leading to quicker recovery times, lesser pain, and minimized scarring. The synergy of artificial intelligence and robotic technology not only augments surgical accuracy but also expands the possibilities of intricate procedures, ultimately benefiting patient outcomes. The advantages of Robot-Assisted Surgeries extend to patient safety, notably in terms of reduced blood loss and infection rates. The precision afforded by robotic systems, guided by skilled surgeons, results in meticulous control over surgical maneuvers, minimizing blood loss. Robot-assisted surgeries usher in a paradigm shift by facilitating minimally invasive procedures through the deployment of robotic arms and instruments. The precision and dexterity of these robotic tools allow surgeons to make smaller incisions, significantly reducing trauma to the patient’s body. 4. Remote Surgery Possibilities One of the revolutionary aspects of Robot-Assisted Surgeries is the potential for remote surgery. Surgeons can operate on patients located miles away, overcoming geographical barriers and ensuring that specialized expertise is accessible where needed. Furthermore, the minimally invasive nature of these procedures, facilitated by smaller incisions, significantly lowers the risk of postoperative infections. This dual benefit not only enhances the overall safety of patients undergoing robot-assisted surgeries but also contributes to favorable outcomes and improved recovery experiences. This not only translates into quicker recovery times but also diminishes postoperative pain and minimizes scarring. The integration of robotic technology into surgical practices signifies a transformative approach to medical interventions, offering patients a less invasive and more The transformative impact of Robot- Assisted Surgeries extends to the realm of remote surgery, marking a paradigm www.thelifesciencesmagazine.com | 37

38. Here are the Drawbacks of Robot-Assisted Surgeries: 1. High Initial Costs The acquisition and implementation of robotic surgical systems entail significant upfront costs for healthcare institutions. This financial burden can limit access to Robot-Assisted Surgeries in certain healthcare settings. 2. Dependence on Technology While AI enhances surgical precision, it also introduces a reliance on technology. Technical malfunctions or system errors during a procedure can potentially compromise patient safety and necessitate rapid troubleshooting. 3. Steep Learning Curve Training surgeons to operate robotic systems requires a considerable investment of time and resources. The learning curve associated with mastering the intricacies of these technologies may slow down the widespread adoption of Robot-Assisted Surgeries. 4. Lack of Tactile Feedback Unlike traditional surgeries where surgeons can feel tissue resistance, Robot-Assisted Surgeries lack tactile feedback. This absence of haptic sensation can pose challenges, as surgeons rely solely on visual and auditory cues. 5. Limited Availability in Rural Settings The advanced infrastructure required for Robot-Assisted Surgeries may not be readily available in rural or underserved areas. This technological disparity exacerbates healthcare inequalities, limiting access to cutting-edge surgical interventions. Future Directions and Conclusion: We are on the verge of a revolution in the healthcare sector as Robot-Assisted Surgeries continue to advance. Technologists, legislators, and medical practitioners must work together to minimize the negative effects and maximize the positive effects of AI in surgical procedures. Finding a happy medium between innovation and accessibility will open the door to a time when Robot-Assisted Surgeries greatly enhance patient outcomes worldwide. 38

40. NEWS OF THE WEEK Challenges Addressed: Traditional provider-collected samples can be uncomfortable or inaccessible. Ÿ Self-collection helps overcome discomfort and lack of trained clinicians. Ÿ FDA Greenlights Self-Collection for Cervical Cancer Screening Current Approvals and Trials: BD Onclarity HPV Assay approved for self-collected samples without a Pap test. Ÿ BD participating in a National Cancer Institute trial to evaluate self-collection accuracy. Ÿ Future Developments: Approval Details: Significance: Roche’s cobas HPV test approved for self-collection. Ÿ FDA approved self-collection of vaginal samples for cervical cancer screening. Human papillomavirus (HPV) causes most cervical cancers; screening for HPV can identify those at risk. Ÿ Ÿ Teal Health’s Teal Wand, a home cervical cancer screening device, granted “breakthrough device” status by the FDA. Ÿ Patients can collect samples in healthcare settings, including doctor’s offices, urgent care, and mobile clinics. Self-collection can expand access to screening and reduce barriers. Ÿ Ÿ Screening Guidelines: Impact: US Preventive Services Task Force recommends cervical cytology screening every three years for women ages 21-29. Ÿ Over 11,000 cervical cancer cases and 4,000 deaths annually in the US. Ÿ Companies Involved: Roche and Becton, Dickson and Company (BD) received FDA approval for self- collected samples with their respective HPV tests. Ÿ For women ages 30-65, the recommendation is every three years with cytology alone, every five years with high-risk HPV testing alone, or every five years with both. Ÿ Self-collection in healthcare settings aims to increase screening rates and early detection, potentially reducing cervical cancer incidence and mortality. Ÿ 40

41. NEWS OF THE WEEK Fewer US Overdose Deaths Reported in 2023, but Experts Remain Cautious CDC Data: Regional Variations: deaths in the U.S. last year, a 3% decrease from 111,000 in 2022. Provisional data shows a decline in U.S. fatal overdoses last year. Declines in overdose deaths in most eastern states, but increases in western states such as Alaska, Washington, and Oregon. Ÿ Ÿ More than 1 million deaths from drug overdoses since 1999. Ÿ Expected to be the second annual decline in over three decades of the drug death epidemic. Ÿ Impacts: Eastern states have been dealing with fentanyl longer than western states. Ÿ Significant ripple effects, including over 321,000 U.S. children losing a parent to overdose from 2011 to 2021. Ÿ Expert Reactions: Experts describe the decline as small, indicating a potential leveling off rather than a significant decrease. Ÿ Optimism and Challenges: These children are at higher risk for mental health and drug use disorders. Potential lower lethality of smoking fentanyl compared to injecting it is being explored. Ÿ Ÿ Previous declines, like in 2018, were followed by increases in subsequent years. Ÿ Drug Trends: Increased funding for addiction treatment and overdose prevention through government initiatives and legal settlements. Ÿ Shift from prescription painkillers to heroin and now illegal fentanyl as primary causes of overdose deaths. Ÿ It’s too early to determine the causes of the decline, which could include changes in the drug supply and expansion of prevention and treatment efforts. Ÿ Conclusion: Increasing use of fentanyl in counterfeit pills and its method of use, shifting from injection to smoking. The decline in overdose deaths is encouraging but requires cautious interpretation. Long-term trends and effective measures to sustain and enhance the reduction are still uncertain. Ÿ Current Statistics: Approximately 107,500 overdose Ÿ www.thelifesciencesmagazine.com | 41

42. New COVID Variant KP.2 Rising: Implications for Spring and Summer Variant Shift: coughing, fever, congestion, fatigue, and in severe cases, shortness of breath. Experts remain cautious and are monitoring for potential summer surges. Ÿ JN.1 variant dominated most of 2023. Ÿ Vaccine Protection: Gastrointestinal symptoms like diarrhea, nausea, and vomiting can also indicate COVID. Ÿ KP.2, a descendant of JN.1, has risen from 1% to over 25% of cases in the U.S. since mid- March. Ÿ Reinfection with KP.2 is possible, especially for those previously infected with JN.1 or who received the latest vaccine targeting XBB.1.5. Ÿ Reinfections often milder but still pose a risk for long COVID, with ongoing research on the extent of this risk. Ÿ KP.2 may evade immune defenses better and be slightly more infectious than JN.1. Ÿ Vaccines still provide protection against severe disease. Ÿ Conclusion: Current COVID Spread: KP.2’s rise is being closely watched, but current data suggests no major immediate threat. Continued vaccination and monitoring are crucial, particularly for vulnerable populations. The virus continues to mutate, emphasizing the need for ongoing vigilance and research. Higher-risk groups (65+, pregnant, immunocompromised) are advised to get the updated vaccine if not already done. Ÿ No immediate rise in cases observed. Ÿ CDC data shows minimal virus levels in wastewater and a decline in emergency visits and hospitalizations. Ÿ Symptoms and Long COVID: Symptoms of KP.2 similar to other variants: sore throat, runny nose, Ÿ New COVID Variant KP.2 Rising: Implications for Spring and Summer Key Findings: determine if Wegovy should be prescribed to heart patients without obesity. High out-of-pocket costs remain a barrier despite insurance. Ÿ A four-year clinical trial of Wegovy, presented at the European Congress of Obesity, showed significant cardiovascular benefits. Ÿ Practical Considerations: Weight Loss and Maintenance: Wegovy and similar drugs are tools to aid in adopting healthier diets and lifestyles, not standalone solutions. Ÿ Average weight reduction of 10% was maintained for up to four years. Ÿ Surprising results indicate reduced heart attack and stroke risks in users, independent of weight loss. Ÿ Weight regain after stopping medication was less dramatic than previously thought. Demand for Wegovy is high, with over 25,000 new users in the U.S. weekly, leading to supply challenges. Ÿ Ÿ Mechanisms Beyond Weight Loss: Dr. Mir Ali from MemorialCare Orange Coast Medical Center suggests these benefits may stem from reduced inflammation and improved blood sugar control. Ÿ Safety and Side Effects: Dr. Ali emphasizes that while Wegovy can significantly aid weight loss and improve heart health, it requires complementary lifestyle changes for optimal effectiveness. Serious side effects like gastroparesis were rare; common issues included nausea, diarrhea, and constipation. Ÿ Further studies are needed to Ÿ 42