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Human Infertility problem

Human Infertility problem Cassey Lynn Jenaia Delk Josh Heise Eric Rooker Summary The problem: There is an unknown cause of female infertility. Attempted for year to become pregnant Long interval between menstruation Suspect problem w/ ovulation Goals: Stimulate ovulation with drugs

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Human Infertility problem

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  1. Human Infertility problem Cassey Lynn Jenaia Delk Josh Heise Eric Rooker

  2. Summary • The problem: There is an unknown cause of female infertility. • Attempted for year to become pregnant • Long interval between menstruation • Suspect problem w/ ovulation • Goals: Stimulate ovulation with drugs • Drugs: • clomiphene citrate • For women w/ infrequent cycles and long cycles

  3. Treatment Regimen • Begin between 2nd-5th day of menses • Patient to take 1 or 2 tablets (50-100mg) every day for 5 consecutive days • Can induce menstrual cycle w/ progesterone injections or progestin tablets. • Pregnancy test before inducing

  4. Drug Action • Name: Clomid, Serophene (Clomiphene Citrate) • Target Cells: Estrogen receptors in the hypothalamus • Cellular Response: Anti-hormone, competitive inhibition • Effect: Block estrogen receptors in hypothalamus to cause increased release of GnRH, LH, and FSH, leading to increased estrogen and ultimately ovulation.

  5. Effect of reproductive state • Effective: • Early in cycle (2-5 days of menstration) • Can induce period (progesterone) • Not Effective: • Times other than above • Women who cannot cycle • pregnant

  6. Determining effectiveness • Cervical mucus test (Billing’s method) • Abdominal pain • Basal Body Temperature (increase) • Blood Tests • Ultrasound • Ovulation Prediction Kit • Endometrial Biopsy

  7. Labor Input • Low input compared to other treatments • Cost is roughly $50/ month • 2 pills early in cycle • Input by medical professional • Determine effectiveness and timing of fertilization • Doctor visits, AI meetings, ultrasounds

  8. Sources • http://www.babycenter.com/0_fertility-treatment-your-options-at-a-glance_1228997.bc • http://www.ansci.wisc.edu/jjp1/ansci_repro/lab/lab7/lab7_2003/human_ov_drugs.pdf • http://www.ansci.wisc.edu/jjp1/ansci_repro/lab/lab7/lab7_2003/ovuldetect.pdf

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