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Avastin 100mg - Anticancer drugs | view uses, side effects and price | MHP

Bevacizumab is a drug sold under the name of Avastin and which is categorized as monoclonal anti-body & anti-angiogenesis @MHP

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Avastin 100mg - Anticancer drugs | view uses, side effects and price | MHP

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  1. BEVACIZUMAB DESCRIPTION Bevacizumab is a drug sold under the name of Avastin 100mg(BEVACIZUMAB) and which is categorized as monoclonal anti-body & anti-angiogenesis. When Avastin 100mg tablet concomitant use with human monoclonal antibody IgG1, that circumstance and prohibits the biological action of human vascular endothelial growth factor (VEGF). Avastin 100mg

  2. USAGE: Avastin 100mg is indicated for the treatment of some of the conditions like Metastatic colon or rectal cancer Non-squamous, non-small cell lung cancer Glioblastoma Metastatic renal cell cancer. Metastatic cervical cancer Epithelial ovarian, fallopian tube or peritoneal cancer. MECHANISM OF ACTION: Avastin 100mg tablet comprises an active compound like Bevacizumab which binds to VEGF and avoid the communication of VEGF to its receptors like Flt-1 & KDR) present on the surface of the cells This interaction prevents endothelial cell multiplication and new blood vessel production occurs Hence in counts cessation of metastatic cancer cells development happens. Avastin 100mg PROPERTIES Ingredients : Bevacizumab Strength : 100mg/4ml Package : 400mg of Bevacizumab containing vial

  3. ADME PROPERTIES Distribution The volume of distribution is 2.9 (22%) L Elimination The Bevacizumab half life period is 20days (11 to 50days) DOSAGE MANAGEMENT KEY POINT Avoid administration of Avastin 100mg tablet before at least 28 days following surgery and the wound is completely cured. METASTATIC COLORECTAL CARCINOMA Concomitant use with 5-fluorouracil based chemotherapy is the usual dosage of Avastin 100mg : While concomitant use with bolus IFL the dose is 5mg/kg of Avastin for every 2 weeks IV. While in combination with FOLFOX4 the dose is 10mg/kg of Avastin for every 2 weeks IV 5mg/kg IV Avastin for every 2 weeks or 7.5 mg/kg Avastin as IV every 3 weeks by concurrently used with fluoropyrimidine Irinotecan or fluoropyrimidine oxaliplatin based therapy. Avastin 100mg

  4. NON-SMALL CELL LUNG CANCER While combining with carboplatin and paclitaxel : The Avastin 100mg tablet usual dosage is 15mg/kg IV for every 3 weeks by Avastin 100mg GLIOBLASTOMA Avastin 100mg For every 2 weeks : 10mg/kg of Avastin 100mg administered IV

  5. METASTATIC CERVICAL CANCER Avastin 100mg Combining with paclitaxel and cisplatin or with paclitaxel and topotecan : The drug Avastin 100mg tablet usual dosage is 15mg/kg of Avastin 100mg given intravenously for every 3 weeks METASTATIC RENAL CELL CANCER Concurrent use with interferon alfa : The Avastin 100mg tablet usual dosage is 10mg/kg IV for every 2 weeks Avastin 100mg

  6. EPITHELIAL OVARIAN, FALLOPIAN TUBE OR PERITONEAL CANCER Platinum opposing: Concurrent use with paclitaxel, pegylated liposomal doxorubicin or topotecan :The Avastin 100mg regular dosage is 10mg/kg of Avastin for every 2 weeks Or Combining with topotecan : The Avastin 100mg regular dosage 15mg/kg of Avastin 100mg given through IV for every 3 weeks Platinum responsive concomitant with carboplatin and paclitaxel for 6 to 8 cycles : The drug Avastinrecommended dosage of is 15mg/kg given IV for 3 weeks Combining with gemcitabine & carboplatin for 6 to 10 cycles : The Avastin 100mg tablet recommended dosage is 15mg/kg of Avastin given IV for 3 weeks. Avastin 100mg PREPARATION & ADMINISTRATION Avastin 100mg tablet is intravenous solution At initial infusion: given IV infusion over 90 minutes Following infusions: give second infusion over 60 minutes, if tolerated Administer all following infusion over 30minutes Avastin 100mg IV infusion is prepared in aseptic condition Avastin 400mg containing 16ml solution whereas 100mg containing 4ml Avastin dilute into 100ml of 0.9% NS Do not dilute with dextrose solution Dispose the remaining portion of medicine which is left in a vial.

  7. PRECAUTIONS There are some complications occurred during treatment with Avastin , care should be taken Arterial thromboembolic events: cessation of treatment with Avastin 100mg tablet in patients who are suffered with severe ATE. Venous thromboembolic events: Toxicity Incidence should be detected; If severe condition therapy should be stopped. Hemorrhage: While on Avastin 100mg treatment some Serious hemorrhages will occur like GI hemorrhage, hemoptysis, Hematemesis, CNS hemorrhage, nose bleeding & vaginal bleeding. Hence Discontinue the treatment. Hypertension: Bp is increased in patients who are receiving Avastin therapy, must be frequently check up with blood pressure and provided with alternative medication for correct the pressure. In hypertension crisis or encephalopathy should be discontinue the treatment. Posterior reversible encephalopathy syndrome Embryo fetal toxicity occurs : During pregnancy condition Avastin 100mg is contraindicated which produce fetal harm. Ovarian failure: The patients who are receiving Avastin may have a chance of getting ovarian failure. Congestive heart failure: the drug combination with anthracycline based chemotherapy, treatment with Avastin 100mg tablet must not be used. Avastin treatment should be stopped while CHF occurs. SIDE EFFECTS Gastrointestinal perforation and fistulae Surgery and wound healing complication Hemorrhage Arterial thromboembolic events Venous thromboembolic events Hypertension Posterior reversible encephalopathy syndrome Renal injury & Proteinuria Infusion reactions Ovarian failure Congestive heart failure Neutropenia, mucosal inflammation, infection, neuropathy, Epistaxis, erythrodysaesthesia Avastin 100mg

  8. PREGNANCY & LACTATION: Pregnancy category: D While administrating Avastin 100mg in pregnant women, positive evidence on fetal risk depends on human studies but potential benefits by using the drug may have common risk against fetus.Avastin 100mg tablet is excreted into breast milk taking account on this, discussion should done on whether to discontinue the breast feeding or the drug. The drug is risky during mother breast feeding to their infants. STORAGE The drug stored at 2 to 8°C (36 to 46°F) Single use vial Dispose the left out vial under the guidance of pharmacists. MISSED DOSE The dose missed by patient should have the dose immediately before the next dose timing reaches, or leave the missed dose and continue the regular schedule. Remember do not have double dose at a time Please consult with doctor for further details. CONTACT US MAIL ID : millionhealthpharmaceuticals@gmail.com PHONE NO :+91-9940472902 WEBSITE :https://millionpharma.com/bevacizumab.php

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