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Effects of Human umbilical cord

A caution is degenerated by studying all the above-mentioned facts that by using hUC-MSCs in lymphoma we increase the risk of tumor growth

Navya_Sharma
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Effects of Human umbilical cord

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  1. Effects of Human Umbilical Cord The mesenchymal stem cells, in short MSCs, are the adult stem cells that shows capacity of self-renewal and potential of differentiation. They mainly occur in the muscle, bone marrow, adipose tissues, placenta, bone and the umbilical cord. The MSCs from the umbilical cord are a more favorable source because of their abundant supply, and lower probability of microbial contamination compared to MSCs from other sources.

  2. Effects of Human Umbilical Cord- Derived Mesenchymal Stem Cells on Hematologic Malignancies Mesenchymal stem cells (MSC) could be used to treat tissue damage, diseases cause by autoimmunity, neurodegenerative diseases, diabetes, and also for cancer therapy. Due to the positive effect of MSCs on hematopoiesis and immune regulation, doctors have been using this in hematopoietic stem cell (HSC) transplantation for a quite long time. However, there has been a debate regarding the application of MSCs in patients because they contain few effects that might promote cancer.

  3. Effects of human umbilical cord- derived mesenchymal stem cells on hematologic malignancies The previous studies show that the transplantation of both HSCs and MSCs at the same time might prevent severe graft-vs.-host diseases, however it might increase the relapse rate in patients with hematologic malignancy relative to the transplantation of HSCs alone. Other observations suggest that the interaction between MSCs and tumors is controlled by many factors, such as the MSCs might migrate to the sites of tumor and then occupy the growth, or provide invasion and metastasis of the tumors.

  4. Effects of human umbilical cord- derived mesenchymal stem cells on hematologic malignancies They regulate the cell cycle and apoptosis of the tumor cells, and also secrete immune regulatory factors to induce immune tolerance which might facilitate the immune escape of a tumor. According to the studies published by different institutions MSCs has shown a direct effect on solid tumors whereas its effect on hematologic malignancies is yet to be studied. In these studies, their effects were closely studied on different types of fatal diseases like multiple myeloma, leukemia and lymphoma.

  5. Effects of human umbilical cord- derived mesenchymal stem cells on hematologic malignancies These diseases fall under the category of hematologic malignancy. This was done to exclude all the experimental conditions and different factors of different sources MSC. It was discovered that the HUC-MSCs most commonly exerted an inhibitory effect on leukemia cells which was also shown in previous researches. Research on the effects of MSCs on lymphoma is controversial and it is possibly due to the different sources of MSCs and the tumor cell types.

  6. Effects of human umbilical cord- derived mesenchymal stem cells on hematologic malignancies It was also shown that the growth of EL4 T-cell lymphoma cells was inhibited by the human adipose tissue derived MSCs by affecting the cell cycle and apoptosis. However, another study proposed that the growth and migration could be promoted by BM-NSCs and also inhibits apoptosis through the activation of the nuclear factor-kB pathway. The secretion of tumor cells can also be affected by the HUC-MSCs.

  7. Effects of human umbilical cord- derived mesenchymal stem cells on hematologic malignancies On a whole, the results showed that there has been a different effect of HUC-MSCs on cells from different types of hematologic malignancy. Cytokines majorly decide the effect of these malignancies, it depends on how cytokine receptors will react on the cells. A caution is degenerated by studying all the above-mentioned facts that by using hUC-MSCs in lymphoma we increase the risk of tumor growth.

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