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Suggestions for success

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Suggestions for success

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    1. Suggestions for success Read the book as much as you can. Print out the slides (1-2/page) and bring them to lecture. Take additional notes on the slides in lecture (or tape the lecture). Go to Discussion Sections to ask questions, and take quizzes to test your understanding and knowledge. You can also form small study groups and share questions. Dont wait until the day before the exam to cram.

    3. Molecular Biology Timeline

    4. The modern framework of Molecular Biology

    5. What was the first informational macromolecule? Proteins ? DNA ? RNA ? Macromolecule no longer used in modern cells ?

    6. The RNA World The RNA world hypothesis posits that there was a stage early in the early evolution of life that was dominated by RNA. Moreover, the functions of RNA in modern cells are only remnants of its previous roles.

    7. Possible remnants of the RNA World Self-splicing introns Rnase P (ribozyme that cleaves tRNA precursors) Self-cleaving viral RNAs Peptidyl transferase in the ribosome Nucleotides (ribo) involved in: metabolism (e.g., ATP, UTP, NADH, NADPH) signaling (cAMP, cGMP, GTP, ITP) assembly of complexes (GTP and ATP) Energy for motility, ion pumping, etc. (ATP, GTP)

    17. Figure 2.16

    18. Double-stranded (DS) DNA statistics (B-form)

    20. 1. Hydrogen bonds between bases

    22. Study Helix Stability with Melting Curves DNA melting curve of Streptococcus DNA. When DNA melts, the 2 strands come apart, and its absorbance in the UV region increases.

    23. Re-Annealing or Hybridization Works with: DNA - DNA DNA - RNA RNA - RNA

    24. G-C content determines melting temperature: varies among organisms

    25. DNA Replication in Prokaryotes and Eukaryotes Overall mechanism Roles of Polymerases & other proteins Mitochondrial DNA replication

    26. Few Questions Is DNA replication conservative, semi-conservative or random dispersed? Fig. 20.1 and 20.3. Is DNA replication bidirectional? Fig. 20.11. Does DNA replication start at the same location or random location?

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