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Animal Welfare Training

Animal Welfare Training. The Development Process. Remember This!. Computer Models Chemical Models In-Vitro Models In-Vivo Models Human Models. The Drug Development Process. Is it safe? Does it work?. Compound X. How much? How often? How should it be put

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Animal Welfare Training

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  1. Animal Welfare Training

  2. The Development Process Remember This! • Computer Models • Chemical Models • In-Vitro Models • In-Vivo Models • Human Models

  3. The Drug Development Process Is it safe? Does it work? Compound X How much? How often? How should it be put into the body?How long does it stay there? Are the effects: short and long? Does it leave the body? How? Does the body change it? How? Do other variables matter? • Safety and Efficacy

  4. Primedica: Nonclinical Contract Research CRO Contract Research Organization • We test drugs, biologics, and medical devices in animalsto prove they are safe and effectivebefore they are tested in people.

  5. Our Product: The Final Report • Attract client • Collaborate on study design • Schedule study • Order/quarantine animals • Receive/Store/Formulate Test Article • Dose Administration • Sample Collection • Process Samples • Euthanasia/Slide Preparation • Tissue Pathology • Deliver the Final Report

  6. Who Regulates Animal Use in Research? USDA United States Department of Agriculture NIH National Institutes of Health IACUC Institutional Care and Use Committee The State Massachusetts Department of Public Health Massachusetts Society for Prevention of Cruelty to Animals AAALAC Association for Assessment and Accreditation of Laboratory Animal Care International

  7. Ethical Issues In Animal Research • Animals As Machines • Greek/Roman games • God Granted Dominion • Humane Stewardship • Rationality and a Soul • “the question is not Can they reason? nor Can they talk? but, Can they suffer?” • Speciesism • prejudiced in favor of one’s own kind

  8. Differentiate Between. . . Remember This! • Animal Welfare • The humane care and use of animals. • Animal Rights • The belief that animal rights are equal to human rights.“A rat is a dog is a boy.”

  9. Some Animals For Some Research • Reduce: Fewer Animals - Same Valid Results • Animal as it’s own control • Statistical analysis • Same animal for more than one study (necropsy) • Refine: Improve Procedures - Reduce Discomfort • Intrabladder catheter / regular urinary catheter • Vascular access port • Replace: Models Without Animals • Harvesting rabbit corneal cells • Bioreactor

  10. IACUC’s Role • Reduce study duplication • Reduce animal discomfort • Justify species/number selection • Assure veterinary care • Ethical Guidelines • Membership • Meetings/Subcommittees • Semiannual Inspections/Program Reviews • Suspension

  11. Animal Welfare Concerns Remember This! • PREVENT/RECOGNIZE/REPORT • Report to a Group Leader, Supervisor, Manager, Study Director, IACUC Member, Vet, or HR • They notify IACUC/Attending Vet, in writing. INVESTIGATE/REPORT The company must investigate/report to the IACUC. IACUC will review the response and investigate too. IACUC will report findings/recommendations to the Institutional Official. RESOLVE/TAKE ACTION The outcome is variable, but serious violations (abuse, neglect) will result in termination(s).

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