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Medical School Histology Basics Blood

Medical School Histology Basics Blood. VIBS 289 lab. Larry Johnson Texas A&M University. Blood (definition and function). Blood - fluid tissue composed of erythrocytes (RBC), leukocytes (WBC), and platelets suspended in blood plasma.

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Medical School Histology Basics Blood

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  1. Medical School Histology Basics Blood VIBS 289 lab Larry Johnson Texas A&M University

  2. Blood (definition and function) Blood - fluid tissue composed of erythrocytes (RBC), leukocytes (WBC), and platelets suspended in blood plasma. Function of blood is the transportation of cells and fluid. RBC carry O2 to and CO2 from tissues.

  3. Blood Function of blood is transportation of cells and fluid. WBC Immune defense for body. Plasma Nutrients to tissues. Waste from tissues. Proteins to hold water in plasma. Hormones and other informational mediators. Platelets Prevent loss of transportation.

  4. Peripheral blood HISTO 021 Erythrocytes Reticulocytes

  5. Reticulocyte Note ribosomes in the reticulocyte

  6. Polychromatophilic normoblasts

  7. Bone marrow 32583 Reticulocyte entering blood vessel Blood vessel

  8. White Blood Cells Neutrophil Eosinophil Neutrophil Eosinophil Monocyte Basophil Basophil Lymphocyte Lymphocyte Monocyte Lymphocyte Monocyte Neutrophil Basophil Eosinophil

  9. White blood cells in blood Eosinophil Basophil Neutrophil Lymphocyte Monocyte

  10. Slide 113 Neutrophils platelets Neutrophils Red blood cells Large lymphocyte Lymphocyte Neutrophils Monocyte

  11. SIZE OF HUMAN BLOOD CELLS CELL/PLATELETSIZE ERYTHROCYTES 6.5-8 µm LEUKOCYTES (WBC) % of WBC NEUTROPHIL 12-15 µm 60-70% LYMPHOCYTE 6-18 µm 25% MONOCYTE 12-20 µm 5% EOSINOPHIL 12-15 µm 2-4% BASOPHIL 12-15 µm 0-1% PLATELETS 2-4 µm

  12. 110 110 Peripheral blood smear (Leishman-Giemsa) Monocyte Neutrophils Monocyte Neutrophils Neutrophils Lymphocyte Monocyte

  13. 110 110 Peripheral blood smear (Leishman-Giemsa) basophil, eosinophil, and neutrophils Lymphocyte Neutrophils Basophil Neutrophils Neutrophils

  14. 110 Peripheral blood smear (Leishman-Giemsa)eosinophil and neutrophil platelets Red blood cells Eosinophil Neutrophil Eosinophil Neutrophil

  15. 113 Slide 113 Peripheral blood smear (May-Grunwald-Giemsa) Neutrophil Monocyte Lymphocytes Monocyte Lymphocyte

  16. 113 Peripheral blood smear (May-Grunwald-Giemsa) Monocyte Lymphocyte Monocyte Monocyte

  17. Slide 113 Peripheral blood smear (May-Grunwald-Giemsa) Lymphocyte

  18. HISTO 021 HISTO 021 60x

  19. HISTO 021

  20. EM 8a EM 8c EM 8c illustrates an example of a basophil Note the neutrophils and eosinophils in EM 8a

  21. 140 Cardiac stomach w/chronic infection Infection site Plasma cells

  22. 140 140 Cardiac stomach w/chronic infection Neutrophil Eosinophil

  23. EM 12b to observe organelle content differences in an immature and mature neutrophils – mature has more mature dumbbell-shaped granules EM 8f

  24. EM 8f Lymphocytes

  25. Note the relative paucity of cytoplasmic organelles and the high nuclear to cytoplasmic ratio (EM 6) EM 6 Lymphocytes

  26. Large Golgi and many plasma membrane projects on monocytes. HISTO 021 Monocytes

  27. Large Golgi and many plasma membrane projects on monocytes. 432 Macrophages (Slide 432) lung EM 8f Monocyte HISTO 021 1 Blood monocytes differentiate into macrophages like those seen in the lungs

  28. Hematopoiesis Simplified: Part 1 Erythropoiesis https://www.youtube.com/watch?v=UTo4LnXonTk&list=PLQltfhuKi1sgtel3O9IpDsbgEWMY3JaX5&index=19 Larry Johnson Texas A&M University

  29. Erythropoiesis Erythrocytes No nucleus and red cytoplasm Reticulocytes No nucleus and blue - grey cytoplasm Orthochromatophilic erythroblasts Dark, small, spherical nucleus blue – grey cytoplasm Darkening, fractured ,spherical nucleus and mixed pools of grey and blue cytoplasm Polychromatophilic erythroblasts Fractured, spherical nucleus and thin rim of dark blue cytoplasm Basophilic erythroblasts Uniformly light, spherical nucleus with thin rim of medium to dark blue cytoplasm Proerythroblasts

  30. McGraw-Hill Companies

  31. Erythropoiesis Proerythroblasts Erythrocytes Reticulocytes Orthochromatophilic erythroblasts Basophilic erythroblasts Polychromatophilic erythroblasts Erythropoiesis

  32. Bone marrow 32583 Reticulocyte entering blood vessel Blood vessel

  33. Bone marrow

  34. EM 12a Bone marrow

  35. Slide 112

  36. Bone marrow

  37. EM 8a marrow blood

  38. EM 12b

  39. EM 8b

  40. EM 8f

  41. EM 8b

  42. 432 Lung with bronchi – macrophage 432

  43. 432 Lung with bronchi 432

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