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Relative Expression of MT1-MMP, MMP-2, and TIMP-2 mRNA in UCC Cell Lines

This study investigates the relative expression levels of the matrix metalloproteinases MT1-MMP and MMP-2, as well as the tissue inhibitor of metalloproteinases TIMP-2, across a panel of urinary bladder cancer (UCC) cell lines, including UMUC3, 253J, HT1376, EJ28, T24, RT112, and HT1197. By analyzing mRNA expression levels, this research aims to elucidate the potential roles of these proteins in cancer progression and metastasis, contributing to a deeper understanding of bladder cancer biology.

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Relative Expression of MT1-MMP, MMP-2, and TIMP-2 mRNA in UCC Cell Lines

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  1. MMP-2 MT1-MMP 90 80 70 70 60 60 50 50 Relative expression 40 40 30 Relative expression 30 20 10 20 0 10 UMUC3 253J HT1376 EJ28 T24 RT112 HT1197 0 UMUC3 253J HT1376 EJ28 T24 RT112 HT1197 TIMP-2 7 6 5 4 Relative expression 3 2 1 0 UMUC3 253J HT1376 EJ28 T24 RT112 HT1197 Relative expression of MT1-MMP, MMP2 and TIMP-2 mRNA in a panel of UCC cell lines

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