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Update on Project P10054: Ex Vivo Rodent Lung Deposition System and Cigarette Smoking Machine

The project P10054 focuses on developing an ex vivo rodent lung deposition system and a cigarette smoking machine to gather data on particle deposition in lung tissues. The lung deposition system aims to provide a modular solution for simulating inhalation in excised rodent lungs, essential for improving particle deposition models in cancer and pharmaceutical research. The cigarette smoking machine seeks to replicate realistic smoking behavior and enhance testing methodologies. Current status indicates delays but progress on collecting essential data is ongoing.

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Update on Project P10054: Ex Vivo Rodent Lung Deposition System and Cigarette Smoking Machine

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  1. Midterm Project Status UpdateP10054 – Ex Vivo Rodent Lung Deposition System/ Cigarette Smoking Machine Frank Forkl (ME) 15 April 2009

  2. Project Status Updates P10054 – Ex Vivo Rodent Lung Deposition System / Cigarette Smoking Machine • Project Family • Bioengineering • Track • Biomedical Systems and Technologies • Start Term • 2009-1 (planned start of MSD I) • End Term • 2009-2 (planned end of MS II) • Faculty Guide • Dr. Risa Robinson (ME) Confirmed Faculty Guide • Technical Support Advisor • Mr. Ed Hanzlik (ME) • Primary Customer • Dr. Risa Robinson (Mechanical Engineering) • American Cancer Society (Unconfirmed) • Secondary Customer • Dr. Kathleen Lamkin-Kennard (Mechanical Engineering)

  3. Project Mission Statement – Ex Vivo Rat Lung • Product Description • Modular system • Produce an aerosol of fluorescent particles • Particles pass into excised rodent lungs inside a pressure controlled chamber • Simulates breathing inside the rodent. • Concentration /flow rate measured on entrance and exit • Lungs will then be sectioned and analyzed to compare against deposition models for more specific spatial distributions • Project Deliverables / Business Goals • System to verify particle deposition models in lungs • Applications in medical research • Pharmaceuticals • Smoking / Cancer Research

  4. Project Mission Statement – Ex Vivo Rat Lung • Primary Market • American Cancer Society / Cancer Research • Pharmaceutical Researchers • Stakeholders • Cancer and other Researchers • Pharmaceutical companies • Users of Inhaled Medications • Patients of Inhalant-caused diseases

  5. Current Status– Ex Vivo Rat Lung • This project does not have a Phase 2. No enhancements to stated goals are envisioned • It is possible that a conceptually similar system could be developed for other deposition studies • Current state of P09054 - behind schedule • Remaining work (if any) would be appropriate for a Co-op/Grad student • Not adequate work level to justify full 5-10 member Senior Design team • Funding for project only secured through 31 December 2009 *Meetings with Ed Hanzlik 3/27/09, Ed Hanzlik and Dr. Risa Robinson 4/1/09

  6. Project Mission Statement – Cigarette Smoking Machine • Product Description • Artificial device to simulate smoking of a cigarette • Reproduce accurate cigarette smoking behavior • Collect data on substances deposited in lungs • Provide a physical test to compare CFD model against • Project Deliverables / Business Goals • Allow for a more realistic picture of substances inhaled by a smoker • Reduce flaws in testing procedure that Tobacco companies have been exploiting • Primary Market • American Cancer Society / Cancer Research • Stakeholders • Cancer and other Researchers • Smokers • Second-Hand Smoke Victims • Cigarette Companies and Retailers

  7. Current Status– P08042Cigarette Smokine Machine • System does not deliver published values of poly aromatic hydrocarbons (nanograms / milligrams) • Barrier to accomplishment of aims of ACS funded research • Staffing: Currently co-op working on project, another lined up for 084 • Goals of project at this Stage • Collecting data on four parameters based on varying inputs • Milligrams of tar/particles/PAH on 44mm Cambridge filter • ng/mg of collected PAH • Particle deposition in plastic lung cast • Size distribution of particles • CFD modeling of lung deposition correlation • Funding for this project more likely to be secured than P10054 *Meetings with Ed Hanzlik 3/27/09, Ed Hanzlik and Dr. Risa Robinson 4/1/09

  8. Goals of Cigarette Smoking Machine • More accurately simulate behavior of smokers • Reduce flaws in testing procedure that Tobacco companies have been exploiting • Collect smoker “profiles” experimentally • Use software like LabView to use these profiles to operate machine based on profiles • Correlate experimentally collected data against CFD models *Meetings with Ed Hanzlik 3/27/09, Ed Hanzlik and Dr. Risa Robinson 4/1/09

  9. Goals of Cigarette Smoking Machine Long-Term • Replicating smokers behavior real-time in data collection • Puff-by-Puff Analysis – Measure carcinogens in each individual puff • Grow actual lung cells in cast to collect more realistic deposition data • Move further into Bioengineering realm • Use P09054 data to improve P10042 *Meetings with Ed Hanzlik 3/27/09, Ed Hanzlik and Dr. Risa Robinson 4/1/09

  10. Objective Tree

  11. Function Tree

  12. House Of Quality

  13. Schedule

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